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Key early steps in gene expression captured in real time by CSU researchers

Scienmag

Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function.

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New cellular atlas maps out healthy and cancerous breast tissue

Scienmag

The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including […].

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How big data analytics can make personalised care a reality

Drug Discovery World

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. This could be expanded to assessing predictors at baseline.

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What to expect from SLAS Europe 2023

Drug Discovery World

Additionally, Dr Gianni will share insights on the use of these new tools in target validation and how they might revolutionise the drug discovery paradigm.

Doctors 52
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FAIR Game: making data work harder in the race to market 

Drug Discovery World

For example, GEO, the gene expression omnibus database, has been collecting gene expression and functional genomics datasets and making them available to the public for more than 20 years. Many efforts have been made to standardise certain types of results.

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Democratising proteomics for cancer and beyond

Drug Discovery World

BMC Bioinformatics. Mass spectrometry-based protein identification by integrating de novo sequencing with database searching. 2013;14 Suppl 2(Suppl 2):S24. doi: 10.1186/1471-2105-14-S2-S24. Epub 2013 Jan 21. PMID: 23369017; PMCID: PMC3549845.

Protein 52
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Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. Then, using DNA synthesis capabilities, oligo pools encoding for specific domains of the antibody are generated as libraries and cloned into a vector.

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