Clinical Development and Drugs - Clinical Research Informer

Digital tools must be used in pharma manufacturing to keep pace with drug discovery and clinical development

pharmaphorum

MARCH 7, 2024

Digital tools must be used in pharma manufacturing to keep pace with drug discovery and clinical development Mike.Hammerton Thu, 07/03/2024 - 09:43 Bookmark this

Clinical Development

Clinical Development Manufacturing Development Drugs

Adcentrx raises funds to advance ADCs into clinical development

Pharmaceutical Technology

APRIL 26, 2023

Biotechnology company Adcentrx Therapeutics has raised $38m in Series A+ financing to advance its pipeline of new antibody-drug conjugate (ADC) therapeutics into clinical development. ADRX-070 is the company’s lead candidate and is anticipated to enter a first-in-human Phase I clinical trial in the second half of 2023.

Clinical Development

Clinical Development Development Clinical Trials Clinical Trials

Acute lymphocytic leukaemia leads in cell therapy clinical development

Pharmaceutical Technology

JULY 12, 2022

The success of chimeric antigen receptor T-cells (CAR-T) in blood cancers has led to the US Food and Drug Administration's (FDA) approval of six products with a pipeline of cell therapies that numbers in the thousands.

Clinical Development

Clinical Development Development Production Sales

Ablaze Pharmaceuticals to develop drug candidate for liver cancer

Pharmaceutical Technology

APRIL 3, 2023

Ablaze Pharmaceuticals is set to develop a new GPC3-targeted peptide drug candidate for the treatment of liver cancer in China. The company is licensing the first-in-class drug candidate under an existing deal with RayzeBio. The agreement allows Ablaze to clinically develop and commercialise the drug in Greater China.

Development

Development Drugs Clinical Development Licensing

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? Ben Locwin will discuss the potential effects of this draft, along with the pharmacological and toxicological considerations for optimizing doses of prescription drugs. A recent draft from the FDA provides valuable insight.

Clinical Research

FDA grants orphan drug designation to MAIA’s glioblastoma agent

Pharmaceutical Technology

NOVEMBER 13, 2023

As per the company, the candidate THIO, is the only direct telomere-targeting agent currently in clinical development.

Clinical Development

Clinical Development Drugs Development

Diversity, Equity, and Inclusion Data Service for clinical development

Drug Discovery World

SEPTEMBER 6, 2023

“Without diverse patient cohorts that accurately reflect the patient population a drug is intended for, we cannot ensure that drugs will be fully safe or effective. It’s clear the industry needs a new approach to deliver more equitable treatments, and our partnership with Krystelis will deliver this.

Clinical Development

Clinical Development Development Clinical Trials Clinical Trials

Vectura Signs Pre-Clinical Development Agreement with Incannex to Advance IHL-216A for the Treatment of Traumatic Brain Injury

Pharma Mirror

JUNE 23, 2021

Vectura Group plc, an industry leading inhalation CDMO, today announced it has signed an agreement with Incannex Healthcare Limited, an Australian cannabinoid medicines development company, to provide pre-clinical development services for IHL-216A, Incannex’s proprietary inhaled drug product for the treatment of traumatic brain injury (TBI).

Clinical Development

Clinical Development Development Manufacturing Medicine

Sosei to regain rights to IBD drug after GSK discontinues programme

Pharmaceutical Technology

NOVEMBER 24, 2023

The Sosei Heptares oral IBD drug was first licensed to GSK in 2020 and is currently in Phase I clinical development.

Licensing

Licensing Licensing Drugs Clinical Development

Insilico Medicine appoints Sujata Rao, M.D., as Senior Vice President to oversee clinical development

Scienmag

JULY 19, 2022

July 19, 2022, New York—Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI) driven drug discovery company, has appointed Dr. Sujata Rao as Senior Vice President (SVP) with responsibility for the global clinical development strategy of Insilico Medicine’s therapeutic programs.

Clinical Development

Clinical Development Medicine Development Drugs

Repurposed Drugs by Luminous Mind for Depression: Likelihood of Approval

Pharmaceutical Technology

JANUARY 22, 2024

Repurposed Drugs is under clinical development by Luminous Mind and currently in Phase I for Depression.

Drugs

Drugs Clinical Development Development

Repurposed Drugs by Luminous Mind for Depression: Likelihood of Approval

Pharmaceutical Technology

JANUARY 22, 2024

Repurposed Drugs is under clinical development by Luminous Mind and currently in Phase I for Depression.

Drugs

Drugs Clinical Development Development

Repurposed Drugs by Luminous Mind for Anxiety Disorders: Likelihood of Approval

Pharmaceutical Technology

JANUARY 22, 2024

Repurposed Drugs is under clinical development by Luminous Mind and currently in Phase I for Anxiety Disorders.

Drugs

Drugs Clinical Development Development

Repurposed Drugs by Luminous Mind for Anxiety Disorders: Likelihood of Approval

Pharmaceutical Technology

JANUARY 22, 2024

Repurposed Drugs is under clinical development by Luminous Mind and currently in Phase I for Anxiety Disorders.

Drugs

Drugs Clinical Development Development

Researchers develop CRISPR-based drug candidate for microbiome targeting

Pharmaceutical Technology

MAY 12, 2023

The Technical University of Denmark (DTU) has announced that an international scientific team has developed a CRISPR-based drug candidate that targets E coli directly and leaves the microbiome intact. The US Food and Drug Administration has granted fast-track designation to SNIPR001, which is currently in clinical development.

Development

Development Bacteria Research Gene Editing

Abzena, Alira Health and Oncodesign launch DRIVE Biologics to support access to specialist services from discovery to clinical development for oncology and inflammation

Pharma Mirror

FEBRUARY 25, 2022

This joint service offering, DRIVE™-Biologics, will leverage Abzena’s strength in design and developability, and cell line development through to commercial manufacturing.

Clinical Development

Clinical Development Development Manufacturing Medicine

Cloud robotics labs are accelerating drug discovery and development

Pharmaceutical Technology

OCTOBER 28, 2022

Drug discovery and development is an incredibly expensive and time-consuming process, taking between 12 and 18 years, and costing on average between $2 billion and $3 billion. Robots can improve drug discovery and development. Remote-controlled robotic labs.

Development

Development Drugs Pharma Companies Life Science

TORL scores $158m in Series B2 to advance ADC cancer therapies

Pharmaceutical Technology

APRIL 10, 2024

TORL plans to use the funds to advance the clinical development of its antibody-drug conjugate (ADC) pipeline.

Clinical Development

Clinical Development Antibody Development Drugs

Cancer Research UK and the KWF Dutch Cancer Society enter partnership to bring multiple drugs into clinical development

Drug Discovery Today

NOVEMBER 7, 2023

Cancer Research UK, and the KWF Dutch Cancer Society (KWF), two of the world’s largest charitable funders of cancer research, announce a new multi-project strategic partnership to advance promising therapeutic agents for cancer through early clinical development.

Clinical Development

Clinical Development Development Research Drugs

US companies drive 2023 drug launches positioned for blockbuster success by 2028

Pharmaceutical Technology

MAY 30, 2023

According to GlobalData’s Looking Ahead to 2023 – the Future of Pharma report, five drugs set for approval in 2023 are projected to attain blockbuster status or near-blockbuster status by 2028 with US company dominance. Genmab AS’s epcoritamab presents as the top European drug launch and only oncological therapy.

Drugs

Drugs Sales Antibody Dermatology

DF-003 by Drug Farm for Chronic Kidney Disease (Chronic Renal Failure): Likelihood of Approval

Pharmaceutical Technology

OCTOBER 27, 2023

DF-003 is under clinical development by Drug Farm and currently in Phase I for Chronic Kidney Disease (Chronic Renal Failure).

Drugs

Drugs Clinical Development Development

DF-003 by Drug Farm for Chronic Kidney Disease (Chronic Renal Failure): Likelihood of Approval

Pharmaceutical Technology

OCTOBER 27, 2023

DF-003 is under clinical development by Drug Farm and currently in Phase I for Chronic Kidney Disease (Chronic Renal Failure).

Drugs

Drugs Clinical Development Development

Corbus and CSPC Megalith sign licence agreement for antibody drug conjugate

Pharmaceutical Technology

FEBRUARY 14, 2023

Precision oncology firm Corbus Pharmaceuticals and CSPC Megalith Biopharmaceutical have entered an exclusive licensing agreement for the latter’s new clinical stage antibody drug conjugate (ADC), CRB-701 (SYS6002). We look forward to working with CSPC to advance clinical development of this asset and realise its full potential.”

Antibody

Antibody Drugs Clinical Development Licensing

FDA grants Orphan Drug Designation to Faron’s bexmarilimab in AML

Pharma Times

AUGUST 29, 2023

The ODD will offer clinical development and commercialisation benefits that will strengthen the drug programme - News - PharmaTimes

Drugs

Drugs Clinical Development Development

ImmunoForge expands agreement with Duke University for drug development

Pharmaceutical Technology

MAY 19, 2023

ImmunoForge has expanded its licence agreement with Duke University in North Carolina, US, to jointly improve research and drug development opportunities. ImmunoForge chief technology officer Dr Jim Balance pioneered the clinical development of peptide drugs genetically fused to ELPs.

Development

Development Drugs Licensing Licensing

€25 million to support clinical developments against Long Covid

Drug Discovery World

MARCH 8, 2023

The post €25 million to support clinical developments against Long Covid appeared first on Drug Discovery World (DDW). This transaction complements the cycle of Covid-19 related syndromes tackled by innovative European biotech companies that benefited from EIB support through its venture debt programme”.

Clinical Development

Clinical Development Development Vaccination Vaccine

BioMed X and Sanofi partner to leverage AI for drug development

Pharmaceutical Technology

OCTOBER 25, 2022

BioMed X has entered a research partnership with Sanofi to leverage artificial intelligence (AI) for drug development. This team will focus on creating a versatile computational platform that can precisely forecast the first-in-class drug candidates’ efficacy in virtual patient groups.

Development

Development Drugs In-Vivo Engineer

Kronos downsizes workforce by 19% to funnel funds into cancer drugs

Pharmaceutical Technology

NOVEMBER 3, 2023

Kronos Bio joins other pharma companies in workforce reductions, cutting 19% of its employees to support clinical development.

Pharma Companies

Pharma Companies Clinical Development Drugs Development

Teijin and Axcelead sign deal for drug discovery research JV

Pharmaceutical Technology

FEBRUARY 21, 2023

Japanese firm Teijin has announced its basic agreement on a capital and business alliance with Axcelead to establish a drug discovery research joint venture (JV) company. In addition to supporting drug discovery research, the new company will investigate and acquire candidate compounds for new drugs.

Research

Research Drugs Clinical Development Development

Anticancer Bioscience Appoints Leader in Oncology Drug Development, Dr. Hong Liu, as US-based VP of Clinical Development

BioTech 365

JULY 14, 2021

Anticancer Bioscience Appoints Leader in Oncology Drug Development, Dr. Hong Liu, as US-based VP of Clinical Development Anticancer Bioscience Appoints Leader in Oncology Drug Development, Dr. Hong Liu, as US-based VP of Clinical Development CHENGDU, China–(BUSINESS WIRE)–#cancer–Anticancer Bioscience (ACB), pioneers … Continue (..)

Clinical Development

Clinical Development Development Drugs

The Power of Personalization Amid the Changing CRO Landscape

Worldwide Clinical Trials

DECEMBER 7, 2023

These survey results also highlight the importance of evaluating a variety of potential CRO partners of different sizes to choose the best match for your clinical development goals and corporate culture. At Worldwide, we understand that every program is different, which means every drug development path forward will be unique.

Clinical Development

Clinical Development Clinical Trials Clinical Trials Trials

US FDA launches lupus consortium to confront drug development challenges

Pharmaceutical Technology

MARCH 30, 2023

The US Food and Drug Administration (FDA)’s Center for Drug Evaluation and Research and the Lupus Accelerating Breakthroughs Consortium (Lupus ABC) have launched the Lupus Research Alliance (LRA) in a bid to advance research for the condition. Asian, Hispanic, and Native American women are also at higher risk.

Development

Development Drugs FDA Approval Clinical Development

FibroGen and Fortis sign exclusive licence deal for mCRPC drug candidate

Pharmaceutical Technology

MAY 9, 2023

FibroGen has signed an exclusive licence agreement with Fortis Therapeutics for the FOR46 antibody-drug conjugate (ADC) that targets a new epitope on CD46, a protein-coding gene. FOR46 is a natural fit with our research and development capabilities and expertise.

Drugs

Drugs Clinical Development Antibody Protein

Brii Biosciences Provides Update on Strategic Clinical Development Progress

BioTech 365

MAY 17, 2021

Brii Biosciences Provides Update on Strategic Clinical Development Progress Brii Biosciences Provides Update on Strategic Clinical Development Progress Company received U.S.

Clinical Development

Clinical Development Development Drugs

New podcast: Revolutionary technology for drug discovery and development

Drug Discovery World

JANUARY 11, 2024

This is the latest episode of the free DDW narrated podcast, titled “Revolutionary technology for drug discovery and development” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. You can also find The Drug Discovery World Podcast on Spotify , Google Play and Apple Podcasts.

Development

Development Drugs Genome Genomics

CRUK and Guardant Health collaborate on precision cancer drugs

Drug Discovery World

DECEMBER 5, 2023

The agreement will enable the parties to discuss opportunities for collaboration to support the charity’s research and clinical development activities, focusing primarily on its clinical trials run by its Centre for Drug Development.

Drugs

Drugs Research Trials Clinical Trials

Zerion and Insud to develop Dispersome formulations of drugs

Pharmaceutical Technology

AUGUST 30, 2022

Zerion Pharma has entered a partnership with Insud Pharma for the development and marketing of drug products using Zerion Pharma's solubility-boosting Dispersome technology. . Under the deal, Zerion will handle the development of Dispersome formulations of marketed drugs.

Development

Development Drugs Bioavailability Production

Novel leukaemia drug receives FDA Orphan Drug Designation

Drug Discovery World

JANUARY 25, 2024

The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to Pleco Therapeutics’s lead compound PTX-252 for the treatment of acute myeloid leukaemia (AML). PTX-252 is a novel molecular entity developed to increase the sensitivity of cancer cells to chemotherapy. cases per 100,000 population, Globocan). .”

Drugs

Drugs Clinical Trials Clinical Trials Clinical Development

Discovery reveals two potential drug targets against skin cancer

Drug Discovery World

APRIL 22, 2024

The discovery of two genes responsible for sensing the environment and adapting cell shape could offer potential new drug targets to stop cancer from metastasising. These genes are good candidates for drug discovery as they have a structure similar to other proteins for which drugs are already in pre-clinical development.

Drugs

Drugs Gene Scientist Research

Arthrosi’s gout drug financed with $75 million Series D

Outsourcing Pharma

JULY 13, 2023

company Arthrosi Therapeutics has bagged $75 million in a Series D round to fund the clinical development of a small molecule drug for chronic gout.

Drugs

Drugs Clinical Development Development Regulation

Bayer looks to expand Kerendia label to include heart failure

Pharmaceutical Technology

SEPTEMBER 1, 2023

Bayer adds three new Phase III heart failure studies to the Kidney and type 2 diabetes drug, Kerendia, clinical development programme.

Clinical Development

Clinical Development Development Drugs

Pharma’s spend on AI in drug discovery ‘could top $3bn by 2025’

pharmaphorum

JULY 8, 2022

The pharmaceutical industry is increasingly relying on artificial intelligence to power its drug discovery and development efforts, and its spend in this area has created a multibillion-dollar market for AI technologies. The post Pharma’s spend on AI in drug discovery ‘could top $3bn by 2025’ appeared first on.

Drugs

Drugs Clinical Development Marketing Genome

Opinion: Drug developers navigating ‘biology’s century’ need a model. We made one

STAT News

MARCH 15, 2023

STAT’s Matthew Herper struck an industry nerve when he wrote that the drug development industry is “not prepared for the next wave of biotech innovation.” ” His report ends on a somewhat dismal note: the industry is long on diagnosis (clinical development is too expensive) and short on cures.

Development

Development Drugs Clinical Development

AlgoTherapeutix Receives Regulatory Approval to Initiate Clinical Development of ATX01

The Pharma Data

DECEMBER 14, 2020

AlgoTherapeutix recently raised a 12M€ Series A that will fund the Phase 1 and 2 clinical development of ATX01. In parallel, AlgoTx firmed-up ATX01’s development pathway via a pre-IND consultation with the FDA and obtained an Orphan Drug Designation from the FDA to explore ATX01’s activity in erythromelalgia.

Clinical Development

Clinical Development Development Clinical Supply Packaging

Digital tools must be used in pharma manufacturing to keep pace with drug discovery and clinical development

Adcentrx raises funds to advance ADCs into clinical development

Trending Sources

Acute lymphocytic leukaemia leads in cell therapy clinical development

Ablaze Pharmaceuticals to develop drug candidate for liver cancer

What the FDA's New Dosage Guidance Means for the Future of Clinical Research

FDA grants orphan drug designation to MAIA’s glioblastoma agent

Diversity, Equity, and Inclusion Data Service for clinical development

Vectura Signs Pre-Clinical Development Agreement with Incannex to Advance IHL-216A for the Treatment of Traumatic Brain Injury

Sosei to regain rights to IBD drug after GSK discontinues programme

Insilico Medicine appoints Sujata Rao, M.D., as Senior Vice President to oversee clinical development

Repurposed Drugs by Luminous Mind for Depression: Likelihood of Approval

Repurposed Drugs by Luminous Mind for Depression: Likelihood of Approval

Repurposed Drugs by Luminous Mind for Anxiety Disorders: Likelihood of Approval

Repurposed Drugs by Luminous Mind for Anxiety Disorders: Likelihood of Approval

Researchers develop CRISPR-based drug candidate for microbiome targeting

Abzena, Alira Health and Oncodesign launch DRIVE Biologics to support access to specialist services from discovery to clinical development for oncology and inflammation

Cloud robotics labs are accelerating drug discovery and development

TORL scores $158m in Series B2 to advance ADC cancer therapies

Cancer Research UK and the KWF Dutch Cancer Society enter partnership to bring multiple drugs into clinical development

US companies drive 2023 drug launches positioned for blockbuster success by 2028

DF-003 by Drug Farm for Chronic Kidney Disease (Chronic Renal Failure): Likelihood of Approval

DF-003 by Drug Farm for Chronic Kidney Disease (Chronic Renal Failure): Likelihood of Approval

Corbus and CSPC Megalith sign licence agreement for antibody drug conjugate

FDA grants Orphan Drug Designation to Faron’s bexmarilimab in AML

ImmunoForge expands agreement with Duke University for drug development

€25 million to support clinical developments against Long Covid

BioMed X and Sanofi partner to leverage AI for drug development

Kronos downsizes workforce by 19% to funnel funds into cancer drugs

Teijin and Axcelead sign deal for drug discovery research JV

Anticancer Bioscience Appoints Leader in Oncology Drug Development, Dr. Hong Liu, as US-based VP of Clinical Development

The Power of Personalization Amid the Changing CRO Landscape

US FDA launches lupus consortium to confront drug development challenges

FibroGen and Fortis sign exclusive licence deal for mCRPC drug candidate

Brii Biosciences Provides Update on Strategic Clinical Development Progress

New podcast: Revolutionary technology for drug discovery and development

CRUK and Guardant Health collaborate on precision cancer drugs

Zerion and Insud to develop Dispersome formulations of drugs

Novel leukaemia drug receives FDA Orphan Drug Designation

Discovery reveals two potential drug targets against skin cancer

Arthrosi’s gout drug financed with $75 million Series D

Bayer looks to expand Kerendia label to include heart failure

Pharma’s spend on AI in drug discovery ‘could top $3bn by 2025’

Opinion: Drug developers navigating ‘biology’s century’ need a model. We made one

AlgoTherapeutix Receives Regulatory Approval to Initiate Clinical Development of ATX01

Stay Connected