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Magazine: Genomic projects exploit scale as clinical applications play catch-up

Pharmaceutical Technology

This month, we take a look at emerging research in this area , including that from the United Kingdom’s 100,000 Genomes Project, and understand how clinical applications could follow in the near future. You can also subscribe here to receive email notifications when a new issue is available.

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COSMIC database matches drugs to cancer mutations

pharmaphorum

The COSMIC (Catalogue of Somatic Mutations in Cancer) database, operated by the Wellcome Sanger Institute, grew out of the work of the Cancer Genome Project and has been gathering data on mutations associated with specific cancers for almost 17 years.

Drugs 59
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Personalising whole genome sequencing doubles diagnosis of rare diseases 

Drug Discovery World

This included additional check-ups for heart problems, hearing loss, and diabetes, and access to clinical trials.” . For further insight into whole genome sequencing, read this DDW exclusive content: Why genomic healthcare data matters in the development of new therapies . of patients. . Official comments .

Genome 52
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Exa-Cel CRISPR Gene Therapy for Sickle Cell Disease Deemed Safe by FDA Advisory Panel

XTalks

The companies used data from the 1,000 Genomes Project but from that, only 61 datasets made the cut to encompass the ideal patient population. “I The FDA scientists agreed that Vertex’s clinical trial results, made available in documents published last week, were “strongly positive.”

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Can Singapore become a global hub for biotech?

Drug Discovery World

In 2019 he was part of a research team which discovered humanised antibody, PRL3-zumab, was effective at shrinking PRL3 over-expressing tumours, and which has since been approved for Phase II clinical trials in Singapore, the US and China.

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Expediting innovation in the rare disease domain

pharmaphorum

Small sample size in trials: Finding eligible patients for clinical trials of orphan medicines is a big challenge. For instance, the UK government’s 100K Genomes Project has achieved its goal of sequencing the genomes of 100,000 people in 2019.

Drugs 78
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Unlocking disease treatment with large-scale research

pharmaphorum

A few decades ago, gathering genetic data on the scale of the 100,000 Genomes Project would have been unthinkable – it was only in 2003 that the entire human genome was mapped. It is likely, just as with the 100,000 Genomes Project, we will be hearing about the breakthrough made possible by this approach in the years to come.