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Modernizing cell culture processes for the next wave of genomic medicine

Pharmaceutical Technology

The field of genomic medicine has reached a true turning point. When you consider the existing challenges limiting the upstream production of viral vectors, this figure becomes even more alarming. We saw a huge potential for these stable cell lines; it’s really the most logical and efficient way to scale up AAV production.

Genome 244
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Can your LNP manufacturing platform cope with the pace of the mRNA revolution?

Pharmaceutical Technology

Genomic medicine development was ranked as the top industry trend for 2023 in a survey of 198 GlobalData Pharma clients and prospects conducted between October and November 2022. Excluding vaccines, there are five mRNA therapeutic products in clinical trial development as of November 2022. billion by 2028.

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The path to improved safety of gene-based products

Drug Discovery World

However, the increased complexity and diversity involved in the development and manufacturing of gene therapies and vaccines can cause challenges when it comes to determining the quality of the final product, particularly around the detection of impurities. Impurities can integrate into the final product at various points during production.

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Guide to using AAV vectors in gene therapy

Drug Discovery World

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. Dr O’Hara also provided an AAV plasmid preparation case study. Why are those important?

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Guide to using AAV vectors in gene therapy

Drug Discovery World

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. Dr O’Hara also provided an AAV plasmid preparation case study. Why are those important?

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The Advantages and Challenges of Next Generation Sequencing in Food Safety Testing

XTalks

As the leader in genomic sequencing, Clear Labs helps its clients better understand and manage pathogens, from foodborne illnesses to SARS-CoV2. This new era of NGS-empowered software tools offers a more accurate and deeper understanding of microbial contamination, helping drive root cause analysis and source eradication.

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Advances in cell line development

Drug Discovery World

CHO cells are typically used for the large-scale production of monoclonal antibodies (mAbs) and recombinant proteins since their ability to grow and divide rapidly under controlled bioreactor conditions makes them suitable for higher yields when producing therapeutics proteins.