Roots Analysis

FEBRUARY 27, 2024

On November 1, 2019, Avacta Group and ADC Therapeutics have announced a collaboration agreement for the development of novel drug candidates. The firm also has the right to obtain exclusive licenses to the Affimer proteins for clinical development and commercialization.

Antibody 52

Antibody Licensing Licensing Contract Manufacturing 52

Roots Analysis

APRIL 15, 2024

These complex entities, such as antibodies, antibody drug conjugates, cell therapies, gene therapies, and therapeutic proteins, are highly specific molecules that are designed to precisely target biomarkers associated with a particular disease pathway.

Manufacturing 40

Manufacturing Production Contract Manufacturing Contamination 40

Roots Analysis

FEBRUARY 26, 2024

In fact, the share of biologics in the overall pharmaceutical contract manufacturing market has increased from 16% in 2006 to over 25% in 2017. Biologics constitute a majority of the top selling drugs and represent one of the fastest growing segments of the overall pharmaceutical industry.

Drug Delivery Systems 52

Drug Delivery Systems Drug Delivery Drugs Contract Manufacturing 52

Pharmaceutical Technology

JULY 29, 2022

Pfizer (New York, New York) and Moderna’s (Cambridge, Massachusetts) Omicron-specific Covid-19 vaccines are in late-stage development, have demonstrated good efficacy against the variant and will likely be available to the public later this year to provide an additional booster and increase demand for injectable manufacturing.

Manufacturing 130

Manufacturing Vaccination Vaccine Packaging 130

pharmaphorum

AUGUST 7, 2020

Under the terms of the agreement Pfizer will become one of several external partners who manufacture the investigational treatment for the disease. Pfizer will provide contract manufacturing services at its facility in McPherson, Kansas, to supply the drug to Gilead.

Manufacturing 116

Manufacturing Contract Manufacturing Protein Allergies 116

pharmaphorum

NOVEMBER 5, 2020

An experimental gene therapy developed by Texas biotech Genprex will be paired with AstraZeneca’s Tagrisso and Merck & Co’s Keytruda – both leading their respective drug classes in the treatment of non-small cell lung cancer (NSCLC). The post Genprex cancer gene therapy paired with AZ, Merck lung cancer drugs appeared first on.

Gene Therapy 98

Gene Therapy Gene Drugs Contract Manufacturing 98

XTalks

JANUARY 29, 2021

They are both checkpoint inhibitors targeted towards programmed cell death protein 1 (PD-1 inhibitors), a protein that is responsible for downregulating the immune system and preventing it from killing cancer cells. As both products target the same pathway, they naturally compete in many indications (Table 1).

Clinical Trials 104

Clinical Trials Clinical Trials Production Trials 104

pharmaphorum

JANUARY 6, 2021

The nomination of a first candidate in the collaboration that will advance into development triggers a $2.5 RNAi uses small RNA molecules to bind to messenger RNA, which is responsible for synthesising proteins, and either destroy it or recruit other cellular factors that regulate its activity.

Gene Silencing 60

Gene Silencing Gene RNA Contract Manufacturing 60

Roots Analysis

MARCH 9, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines, and gene therapies), by the US FDA, have steadily risen. Biopharmaceutical Excipient Manufacturing Market. Biopharmaceutical Excipient Manufacturing Market. Concluding Remarks.

Manufacturing 52

Manufacturing Marketing Contract Manufacturing Protein 52

Roots Analysis

OCTOBER 24, 2023

Different Types of HPAPIs The new generation of APIs being developed are highly complex in nature, including peptides, HPAPIs, oligonucleotides and sterile APIs. The ADCs bind to specific proteins or peptides in cancer cells with very high specificity and efficacy influencing the biological functions.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

pharmaphorum

DECEMBER 18, 2020

GSK estimates that around 60% of the 300,000-plus severe SLE patients in the US suffer from lupus nephritis each year, and a quarter of those develop end-stage renal disease. Benlysta binds and neutralises the B cell survival factor BAFF, while rituximab targets CD20, a protein found on the surface of B cells.

FDA Approval 93

FDA Approval Contract Manufacturing Sales Trials 93

Roots Analysis

MARCH 13, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry.

Manufacturing 52

Manufacturing Drug Delivery Marketing Drug Delivery Systems 52

Drug Discovery World

DECEMBER 14, 2023

With leading academic institutions and significant recent investment, Glasgow is shaping up to be an important centre for drug discovery and development in the UK. DDW’s Diana Spencer explores the city’s unique ecosystem. Discoveries in these areas will identify new treatments which will become the cancer drugs of the future.”

Drugs 75

Drugs Life Science Research Scientist 75

XTalks

FEBRUARY 27, 2024

XTALKS WEBINAR: Development of CAR-T Cells for T-ALL Targeting CCR9 Live and On-Demand: Wednesday, March 6, 2024, at 11am EST (4pm GMT/UK) Register for this free webinar to explore the developments in cancer immunotherapy targeting CC chemokine receptor 9 (CCR9), a potential breakthrough for T-cell acute lymphoblastic leukemia (T-ALL).

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

Roots Analysis

AUGUST 8, 2023

Disposable bioreactors have transformed the process of conventional biomanufacturing, and their adoption is increasing rapidly for production of various biologics, such as antibody, recombinant proteins, cell and gene therapy. There are a number of companies that are now involved in the development of advanced single use bioreactors.

Manufacturing 52

Manufacturing Production Marketing Gene Therapy 52

XTalks

APRIL 11, 2024

Moreover, rather than producing antibodies, the cancer cells produce abnormal proteins that can cause complications. This could be seen as a positive for companies developing CAR T-cell therapies for autoimmune diseases and solid tumors. In addition, the companies are also gunning for a first-line setting approval.

FDA Approval 52

FDA Approval Manufacturing Trials Clinical Trials 52

The Pharma Data

MARCH 22, 2022

Pfizer continues to invest to support the manufacturing and distribution of PAXLOVID, including exploring potential contract manufacturing options. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus.

In-Vitro 52

In-Vitro Contract Manufacturing Manufacturing Production 52

Pfizer

DECEMBER 13, 2021

Shot of a Lifetime: How Two Pfizer Manufacturing Plants Upscaled to Produce the COVID-19 Vaccine in Record Time. After Pfizer and BioNtech signed a letter of intent in March 2020 to work together on a vaccine, two Pfizer facilities were swiftly selected for developing the processes and manufacturing the product at an industrial scale.

Manufacturing 52

Manufacturing Vaccination Vaccine Production 52

Drug Discovery World

SEPTEMBER 6, 2022

DDW Editor Reece Armstrong looks at the cell and gene therapy landscape, examining the challenges facing developers and the trends we can expect to see throughout the year. . Thompson says that the development of Covid-19 vaccines, which used mRNA technology, resulted in wider acceptance for cell and gene therapies. . “On

Gene Therapy 52

Gene Therapy Gene Manufacturing Medicine 52

The Pharma Data

OCTOBER 6, 2021

We are committed to investing in the development of additional production platforms for biologics based on the latest technologies,” said Hubertus von Baumbach, Chairman of the Board of Managing Directors. Biopharmaceutical Contract Manufacturing Boehringer Ingelheim is one of the leading manufacturers of biopharmaceuticals.

Production 52

Production Contract Manufacturing Manufacturing Branding 52

Roots Analysis

FEBRUARY 13, 2023

Messenger ribonucleic acid (mRNA) is a single-stranded molecule, which carries coding sequence and plays a prominent role in protein synthesis. It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein.

Manufacturing 52

Manufacturing Drug Delivery Systems Genetic Engineering RNA 52

The Pharma Data

DECEMBER 23, 2020

Cellular (T cell) response were observed to multiple regions of the spike protein including the RBD region. INOVIO has assembled a global coalition of collaborators, partners and funders to rapidly advance the development of INO-4800. . The 1.0 mg and 2.0 mg dose group. Department of Defense.

DNA 40

DNA Vaccination Vaccine Immune Response 40

pharmaphorum

NOVEMBER 12, 2020

In 2018, it bought Element Genomics – a spin-out of Duke University in the US – to add genome-editing technologies, and has also been growing its internal exercise at its Boston R&D hub, although so far it hasn’t advanced and gene therapies into clinical development.

Gene Therapy 52

Gene Therapy Gene Manufacturing Contract Manufacturing 52

Drug Discovery World

FEBRUARY 2, 2023

Bryan Oronsky , Chief Development Officer at EpicentRx, discucsses how one drug sourced from the defense and aerospace industry, could have many potential disese targets. A late-stage clinical trial in head and neck cancer for the treatment of severe oral blistering or oral mucositis caused by radiation therapy is planned.

Manufacturing 52

Manufacturing Clinical Trials Clinical Trials Drugs 52

XTalks

FEBRUARY 11, 2021

Amidst growing global shortages of COVID-19 vaccine supplies, inaugural (by way of authorizations/approvals) COVID-19 vaccine maker Pfizer is addressing the issue by working to cut the manufacturing time of its vaccine by almost half. Pfizer based its production system on how the vaccine was developed in the laboratory, Calitri said.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

Roots Analysis

OCTOBER 3, 2023

Specifically in the healthcare industry, the development of novel bioreactor and fermenter technologies has led to significant advancement in bioprocessing, biomanufacturing, and synthetic biology, enabling the production of innovative bioproducts with high purity, yield, and quality.

Vaccination 40

Vaccination Vaccine Production Manufacturing 40

Roots Analysis

JANUARY 24, 2024

Continuous manufacturing process involves the production of pharmaceutical drug substance in a single run, while operating 24×7. In this process, the drug is developed from its base ingredients / raw materials and processed to the final product in one facility, without any hold time.

Manufacturing 40

Manufacturing Contract Manufacturing Production Marketing 40

Pharmaceutical Technology

APRIL 24, 2023

“Biologics products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

Contract Manufacturing 130

Contract Manufacturing Manufacturing Protein Sales 130

The Pharma Data

MAY 4, 2021

to $3.65, Primarily Reflecting Updates to Anticipated Contributions from BNT162b2 Partially Offset by Additional R&D Expenses for Vaccines to Protect Against COVID-19 as Well as Other mRNA-Based Development Programs and COVID-19 Antivirals. Billion Doses Expected to be Delivered in 2021 Under Signed Contracts as of Mid-April 2021.

Vaccination 40

Vaccination Vaccine Production Sales 40

XTalks

NOVEMBER 11, 2021

The NIH says their scientists played “a major role” in developing Moderna’s COVID-19 vaccine and, hence, plans to defend its claim of co-ownership, NIH Director Dr. Francis Collins told Reuters. The COVID-19 vaccine patent is for the specific genetic sequence of the spike protein used in the Spikevax vaccine.

Vaccination 98

Vaccination Vaccine Scientist Contract Manufacturing 98

Pharmaceutical Technology

DECEMBER 15, 2022

The Singapore Government has launched Biologics Pharma Innovation Programme Singapore (BioPIPS), which aims to increase the country’s manufacturing capacity for biologics, including recombinant proteins and vaccines. Most of the approximately 30 contract manufacturing facilities in Singapore are foreign-owned.

Manufacturing 264

Manufacturing Vaccination Vaccine Production 264