Scienmag

JUNE 7, 2021

Divita Mathur, Research Assistant Professor, is studying cytosolic access and instability of DNA nanoparticles. A number of candidate therapies such as CRISPR-Cas9 and gene silencing require the efficient delivery of functional nucleic acids to the cell cytosol and nucleus.

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DNA Gene Silencing Gene Research 51

Scienmag

JULY 2, 2021

The ongoing effort to explore […].

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Gene Silencing Gene Editing Gene DNA 75

pharmaphorum

APRIL 13, 2021

It’s the chronic form of the disease that is the main target, with Ionis is working with GSK on an antisense drug that can suppress the hepatitis B virus (HBV), and Roche is working with Dicerna on a rival gene silencing drug.

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Gene Silencing Trials Drugs DNA 64

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. It’s a great tool for controlling gene expression.”. pyogenes dCas9.

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DNA Gene Gene Silencing Genome 98

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. These modifications regulate gene expression without altering the sequence or structure of DNA.

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DNA Gene Gene Silencing Genome 52

Drug Discovery World

AUGUST 1, 2023

circRNA has also been used to upregulate advantageous endogenous circRNA expression in both cultured cells and animal models. In drug discovery, its potential has skyrocketed following its use in a number of Covid-19 vaccines, with Pfizer’s Covid-19 vaccine becoming the first mRNA product to achieve full FDA approval in the US 6.

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RNA Drugs Gene Silencing Vaccination 52

Drug Discovery World

JANUARY 23, 2023

Such stocks have already been created using conventional CRISPR-Cas9 approaches; however, cells edited with CRISPR-Cas9 have an increased risk of random insertions and deletions (indels) which are introduced during a cell’s intrinsic DNA repair process following a DNA double strand break (DSB) from Cas9. 2016;353(6305):aaf8729.

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Gene Editing Gene Engineer DNA 52