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Researchers uncover molecular pathways underlying depression

Drug Discovery World

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. Scientists have long known that there may be a genetic component that confers predisposition to depression, but the specific underlying mechanisms have remained elusive.

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World Mental Health Day 2023: Drug discovery breakthroughs

Drug Discovery World

Read more: First oral drug for postpartum depression approved in US The role of genetics In October, scientists discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets.

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Q&A with Mark Garner: The golden age of cancer research  

Drug Discovery World

A fulfilling part of my job is meeting the scientists, companies, and institutions at the forefront of ground-breaking research that are advancing patient health outcomes. The European Commission notes that whilst Europeans only make up one tenth of the global population, 25% of annual cancer cases fall within Europe.

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2023 cancer research highlights: Drug development at its best

Drug Discovery World

Scientists have used CRISPR gene editing to target and rapidly destroy glioblastoma cells in an approach that could apply to other highly mutated cancers. In glioblastoma, as with many other highly recurrent cancers, tumour cells that escape treatment develop multiple genetic adaptations that allow them to proliferate.

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Accelerating biotherapy and personalised medicine with long DNA

Drug Discovery World

Matt Hill , Founder and CEO of Elegen writes about the importance of innovation in DNA synthesis to address critical bottlenecks in biotherapy development. Regardless of the type of disease targeted, at the core of biotherapy development is synthetic biology and the use of synthetic DNA to programme specific behaviours within living cells.

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Who are the AACR Scientific Achievement Award winners?

Drug Discovery World

The American Association for Cancer Research (AACR) will honour the following cancer researchers, physician-scientists, advocates, and journalists during its annual meeting to be held April 14-19 at the Orange County Convention Center in Orlando, Florida. Dalla-Favera’s award lecture will be held on Tuesday April 18 at 3:45pm ET.

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The path to improved safety of gene-based products

Drug Discovery World

Another dangerous consequence can occur when the therapeutic or vaccine introduces proteins that can activate an uncontrolled immune response. In the case of therapeutics, the aim is usually to avoid patients’ immune responses. Impurities can integrate into the final product at various points during production.