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Genetic biomarkers could personalise therapy for TNBC

Drug Discovery World

Triple negative cancers are not driven by any of the three molecules that can be blocked by targeted hormone receptor drugs – the HER2 protein and two hormone receptors for oestrogen and progesterone – and so current treatment options are limited.

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Silence Tx uses game to raise thalassaemia awareness

pharmaphorum

Thalassaemia is a severe genetic disease that is characterised by significantly reduced production of functional beta-globin, a component of haemoglobin, the oxygen-carrying protein in the blood. It has a candidate in development that targets TMPRSS6, an enzyme that reduces levels of a protein (hepcidin) that controls iron levels in the body.

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Personalized Blood Test Detecting ctDNA Can Help Predict Lung Cancer Relapse

XTalks

XTALKS WEBINAR: Using CRISPR interference (CRISPRi) Viability Screens to Map Long Noncoding RNA Dependencies in Tumor Cells. Register for this webinar to get an overview of the role of long non-protein coding RNAs (lncRNAs) in gene regulations. Live and On-Demand: Thursday, April 21, 2022, at 11am EDT (4pm BST/UK).

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Moderna and BioNTech – who are they?

pharmaphorum

Their technology is based on synthetic messenger RNA – short for ribose nucleic acid – which is a short transcript of a longer DNA code. As it’s just a messenger molecule, it does not affect the body’s own genetic code when it is injected as a vaccine – but what it does do is instruct cells to code for copies of a certain protein.

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Investigators Discover Unique Immune Cells in Patients with Checkpoint Inhibitor-Induced Arthritis

The Pharma Data

8, 2020 /PRNewswire/ — Since doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed that a subset of these patients experience a side effect that clinically looks like inflammatory arthritis. NEW YORK , Nov.

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STAT+: Foundation charges cancer patients $83,000 for unproven but promising experimental drug

STAT News

Still, when doctors told her last year that the cancer was growing despite two operations, radiation therapy, and a fifth regimen of chemotherapy, the retired business-meeting facilitator decided to do something unorthodox: spend $83,000 out of pocket on an unproven experimental cancer vaccine.

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New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors

Bioengineer

“For the first time, we identified a crucial interaction between platelets and the tumor via their surface proteins,” Jain said. ” Jain’s team in College Station for this research includes postdoctoral researcher Dr. Biswajit Saha and doctoral students Jim Tronolone and Tanmay Mathur.