The Pharma Data

AUGUST 19, 2021

Food and Drug Administration (FDA) approval of the VENTANA MMR RxDx Panel, advancing the company’s commitment to personalised healthcare through tests that determine which patients are most likely to benefit from specific and targeted therapies. Defects in the MMR machinery have been attributed to mutations in the MMR proteins.

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Drug Discovery World

SEPTEMBER 29, 2022

Challenges in outsourcing drug discovery. The goal of drug discovery is clear: Identify the most promising leads in the shortest amount of time. Alternatively, some targets require novel, innovative solutions that may not be accessible in conventional drug discovery labs. Minimising reagent consumption and costs.

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Reagent DNA Scientist Drugs 52

Drug Discovery World

NOVEMBER 28, 2023

Scientists at the University of Bath have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells. Drug treatments often work by binding to proteins involved in disease and blocking their activity, which either reduces symptoms or treats the disease.

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Protein Drugs Reagent Life Science 59

Drug Discovery World

APRIL 3, 2023

Also, the large, immunogenic nature of antibodies and protein ligands as therapeutic molecules means our partners are looking for alternative solutions that offer reduced immunogenicity and improved tissue penetration properties. As such, working with large protein delivery vehicles like antibodies can remove these therapeutic benefits.

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The Pharma Data

JANUARY 24, 2021

“We are excited to welcome Chris, a highly regarded drug developer and team builder who brings to Notch great depth of experience and expertise in development of cell therapies, gene editing, and cell engineering spanning discovery through IND,” said David Main , President and Chief Executive Officer of Notch.

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Engineer Gene Editing Genome Genomics 52

The Pharma Data

OCTOBER 19, 2020

DB ( Becton, Dickinson and Company ) received a CE mark for its BD Multitest 6-Color TBNK Reagent with BD Trucount Tubes for assessing immune function in COVID-19 patients. A new clinical trial by the World Health Organization (WHO), however, reports that the drug does not have any particular effect on a patient’s survival.

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Drug Discovery World

DECEMBER 28, 2022

Gyrolab Biomarker Kits – Gyros Protein Technologies . Gyrolab Human Cytokine Kit Reagents are the first in a range of new biomarker kits from Gyros Protein Technologies. . The post The latest drug discovery product launches appeared first on Drug Discovery World (DDW).

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Pharmaceutical Technology

APRIL 28, 2023

Its scope includes Syngene providing integrated drug discovery and development solutions in discovery chemistry and biology, peptide chemistry, antibody and protein reagents, pharmacokinetics and drug metabolism, and pharmaceutical development. until 2026.

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Drug Discovery World

OCTOBER 21, 2022

Accordingly, advances in flow cytometry technology – both in instrumentation and reagent offerings – are enabling researchers to decipher these questions, leading to new discoveries and diagnostic tools. . Reagents produced under ISO certification provide an extra level of traceability to support internal documentation and quality assurance.

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Reagent Antibody Drugs Protein 52

Drug Discovery World

NOVEMBER 30, 2023

This presentation covered three primary drivers for a protein expression model: speed, cost and sustainability. “It The next presentation attended in this track was the keynote presentation, which was given by Kate Smith, PhD, Head of UK Protein & Cell Sciences at GSK. GSK has developed high-throughput mammalian and E.

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Antibody Protein Engineer In-Vivo 59

Drug Discovery World

AUGUST 22, 2022

Charles River, Antibody Discovery group, has integrated computational immunology, antibody engineering and phage display technologies into its comprehensive antibody discovery platforms that rapidly deliver antibody hits or optimised variants with a range of affinities, cross-species coverage, and improved drug-like characteristics.

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Antibody Reagent Engineer Protein 52

Roots Analysis

FEBRUARY 13, 2023

Messenger ribonucleic acid (mRNA) is a single-stranded molecule, which carries coding sequence and plays a prominent role in protein synthesis. It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein.

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Manufacturing Drug Delivery Systems Genetic Engineering RNA 52

Drug Discovery World

SEPTEMBER 20, 2022

Join DDW & Charles River Laboratories in this free webinar examining how the company uses Octet Bio-Layer Interferometry (BLI) to help inform its drug discovery campaigns and workflows. Octet BLI applications in reagent quality control including binding interaction studies and rapid antibody quantitation using minimal and crude samples.

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Antibody Reagent Protein Scientist 52

Drug Discovery World

AUGUST 30, 2022

The webinar elaborates on the use of the Octet BLI for quality control of proteins, high throughput hit screening with crude single chain library clones, blocking/competition assays using crude and purified samples, and kinetic determination of antibody-antigen binding. To secure your place, register for FREE now.

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Antibody Reagent Protein Scientist 52

Drug Discovery World

AUGUST 22, 2022

Charles River, Antibody Discovery group, has integrated computational immunology, antibody engineering and phage display technologies into its comprehensive antibody discovery platforms that rapidly deliver antibody hits or optimised variants with a range of affinities, cross-species coverage, and improved drug-like characteristics.

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Antibody Reagent Engineer Protein 52

Drug Discovery World

OCTOBER 12, 2022

Professor Michael Butler, head of the National Institute for Bioprocessing Research and Training (NIBRT) Cell Technology Group (CTG), explains that the characterisation and analysis of glycans is important for the biopharma sector as it can help in the development of therapeutic agents such as monoclonal antibodies and other recombinant proteins.

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Protein Gene Therapy Antibody Production 52

pharmaphorum

FEBRUARY 3, 2021

While achieving the Nobel Prize spotlight would have been enough to impress, CRISPR-Cas9 gene editing is part of a growing list of technologies granted Investigational New Drug (IND) applications with early data from clinical trials supporting its safe use in edited cells re-introduced into a patient. Improving on impressive first steps.

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Gene Editing Gene DNA Engineer 98

XTalks

APRIL 22, 2022

Both the areas of drug development and clinical trials are increasingly using in vitro assays to help determine the efficacy of an investigational therapeutic. Among these is the receptor occupancy assay, which is a powerful method used to understand how a therapeutic drug binds to (or occupies ) its receptors on the surface of certain cells.

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Clinical Trials Clinical Trials Trials Antibody 98

Drug Discovery World

MARCH 13, 2023

Before 2019, CGT drug developers still had a young, academic mindset, ordering reagents, materials, and equipment haphazardly and assuming they would show up when needed. But now, the increased efficiency is likely making drug development cheaper. Additionally, the complexity of these drugs remains vastly under appreciated.

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Drug Discovery World

DECEMBER 13, 2023

Antibodies are used as therapeutics, components of therapeutics such as antibody-drug conjugates (ADC) and CAR-T cells, and as companion diagnostic tools. Fortis Life Sciences offers custom antibody discovery and manufacturing services for antibodies and single-domain antibodies, supporting the drug discovery market.

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Life Science Antibody Manufacturing In-Vivo 59

Drug Discovery World

FEBRUARY 27, 2023

The company launched its EnVision Nexus system at the show, which is designed for demanding HTS applications and to help accelerate drug discovery efforts. As the company’s first HT system, it has been designed to overcome adoption barriers currently limiting the use of predictive human liver models within drug discovery workflows.

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Drugs Life Science Protein Scientist 52

Roots Analysis

AUGUST 28, 2022

Furthermore, several live cell imaging and non-destructive fluorescence histological methods measure limited number of biomarkers at a time and the tags introduced may interfere with the natural function of genes and proteins. In fact, platform integration agreements account for 18% of the total deals inked in this domain, since 2016.

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Genome Genomics RNA Genome Project 52

Drug Discovery World

JUNE 6, 2023

So, I really look forward to the coming year and being in beautiful San Diego next year.” Meet the biotech Sygnature Discovery is an integrated drug discovery and non-clinical solutions provider, offering expertise across a range of therapeutic areas and biological target classes.

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Drug Discovery World

JULY 18, 2023

Current research is focused on designing CRISPR-enhanced CAR T cells that are resistant to immunosuppressive cytokines such as transforming growth factor-β (TGF-β) 2 , programmed cell death protein (PD-1) 3 , or other negative T cell regulators 4 (CTLA-4, LAG-3, and TIM-3), thus improving anti-tumour functions.

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DNA Genome Genomics RNA 98

Drug Discovery World

OCTOBER 14, 2022

HTS as a tool for drug discovery has evolved rapidly since the origin of the technique in the 1990s. HTS is widely used by pharmaceutical companies to identify compounds (or ‘hits’) that show pharmacological activity, which are used as starting points to optimise medicines during the drug discovery process.

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Drug Discovery World

FEBRUARY 8, 2023

This helps ensure a high concentration of loaded capsids and adequate removal of impurities, such as host cell proteins and DNA. The threat of empty capsids Capsids are the protein shell that would usually enclose the genetic material of a virus. A crucial part of the AAV workflow is the purification of viral vectors.

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Gene Therapy Gene Antibody Production 52

Drug Discovery World

DECEMBER 15, 2022

Potential solutions: For CRISPR systems, the likelihood of off-target editing has been shown to be influenced by a variety of factors, ranging from the design of the gRNA 1 and Cas9 protein 2 , to the targeted cell type 3 , to name a few examples.

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Gene Editing Gene In-Vivo Genome 52

Drug Discovery World

OCTOBER 20, 2022

It has been used to investigate rare cell populations, screen potential drug therapeutics, and examine sample phenotypes for diagnostic applications 2. Immunohistochemistry is a valuable tool that provides detailed images of the spatial relationships between cells in tissues and proteins in cells, in their most native, non- denatured states.

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Antibody In-Vivo Life Science Development 52

Drug Discovery World

JUNE 14, 2023

In acknowledgement of Blood Donor Day 2023, DDW spoke with industry experts about the significance of blood donorship in drug discovery. Bill Block, President & CEO of Blood Centers of America Bill Block is President and CEO of Blood Centers of America (BCA).

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Manufacturing Production Gene Therapy Development 52

The Pharma Data

OCTOBER 14, 2020

The AOP Orphan Group manufactures 80% of its drugs in Europe and has more than 20 subsidiaries and representative offices across the whole of Europe as well as in the United Arab Emirates and Israel. Food and Drug Administration granted Breakthrough Therapy designation to France-based Inventiva’s experimental NASH treatment lanifibranor.

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