Mon.Dec 27, 2021

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Kidney damage as a result of coronavirus infection

Scienmag

The Coronavirus SARS-CoV-2 infects the kidneys and contributes to tissue scarring, as shown by researchers from the RWTH Uniklinik Aachen, Germany, and Radboudumc, The Netherlands. The developed scar tissue in the infected kidneys may suggest a possible impact on kidney outcomes in the long term. Credit: Jitske Jansen and Bart Smeets, Radboudumc The Coronavirus SARS-CoV-2 […].

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Association Between Immune Dysfunction and Breakthrough COVID-19 Infection After Vaccination

JAMA Internal Medicine

This cohort study compares COVID-19 incidence, risk, outcome severity, and treatment response between immunocompromised individuals and those without immune dysfunction conditions before and after SARS-CoV-2 vaccination.

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Penn Medicine awarded $14 million NIH grant to apply CAR T immunotherapies to match more patients in need of kidney transplants

Scienmag

PHILADELPHIA — Penn Medicine has been awarded a prestigious seven-year, $14 million grant from the National Institutes of Health (NIH) to promote organ transplantation for patients with end-stage renal disease who are currently on the waitlist for a kidney transplant. The team will launch a clinical trial harnessing synthetic chimeric antigen receptor (CAR) T cells […].

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His Power and Glory Evermore Proclaim: The Weary World Rejoices

Pharma Packaging Solutions

But those who hope in the Lord will renew their strength. They will soar on wings like eagles; they will run and not grow weary, they will walk and not be faint. Isaiah 40:30 NIV This is my God story – a story of His peace, His love, and my hope. My hope was in the Lord during a long difficult journey of recovery and rehabilitation after a near-fatal car accident.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Is energy the key to Alzheimer’s disease?

Scienmag

A team of researchers at the University of Adelaide has found a link between the way that cells produce energy for brain function and the mutated genes found in Alzheimer’s disease. Credit: Pixabay. Photo by Pete Linforth. A team of researchers at the University of Adelaide has found a link between the way that cells […].

Gene 91
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AROMATASE INHIBITORS IN BREAST CANCER

Pharma Tutor

AROMATASE INHIBITORS IN BREAST CANCER. About Authors. MANISHA KOTADIYA*, JAYDEEP SAVALIYA. *Shree Swaminarayan Sanskar Collage of Pharmacy Zundal, Gandhinagar, Gujarat, Email Id: manishakotadiya3@gmail.com, FTF Pharma Pvt. Ltd. – Ahmedabad, Email ID: jaydeepsavaliya27@gmail.com. DOWNLOAD AS PDF. admin. Mon, 12/27/2021 - 15:34. Tags. Articles.

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New patent expiration for Mylan Speciality drug ACCUNEB

Drug Patent Watch

Annual Drug Patent Expirations for ACCUNEB Accuneb is a drug marketed by Mylan Speciality Lp and is included in one NDA. It is available from one supplier. There is one…. The post New patent expiration for Mylan Speciality drug ACCUNEB appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Rethinking how drugs are administered: A breakthrough in microneedle patches

Scienmag

Ishikawa, Japan – The painful feeling of receiving an injection through a hypodermic needle or with the unpleasant sensation of swallowing a large pill is a globally familiar sensation. But what if a revolutionary and gentler way of administering drugs was in the works? For over two decades, researchers have been investigating various types of […].

Drugs 83
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New patent expiration for Mylan Speciality drug DUONEB

Drug Patent Watch

Annual Drug Patent Expirations for DUONEB Duoneb is a drug marketed by Mylan Speciality Lp and is included in one NDA. There is one patent protecting this drug. This drug…. The post New patent expiration for Mylan Speciality drug DUONEB appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Why are certain heavy metals okay to eat? (video)

Scienmag

WASHINGTON, Dec. 27, 2021 — Heavy metals have a reputation for being dangerous, but some are essential nutrients that you can’t live without. In this week’s episode of Reactions, we explore why: [link] Credit: The American Chemical Society WASHINGTON, Dec. 27, 2021 — Heavy metals have a reputation for being dangerous, but some are essential […].

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Predictive Oncology Adjourns Annual Meeting of Stockholders to December 30, 2021

BioTech 365

Predictive Oncology Adjourns Annual Meeting of Stockholders to December 30, 2021 Predictive Oncology Adjourns Annual Meeting of Stockholders to December 30, 2021 MINNEAPOLIS, Dec.

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Focus on Fossils: Paleobiologists to Unearth Ancient Megafauna in East Africa, Forecast How Humans and Climate Affect Wildlife

Scienmag

Jenny McGuire plans to use the late Cenozoic fossil record in Africa — a span of 7.5 million years — to study the long-term relationships between animals, their traits, and how they respond to changes in their environments. The goal is to use the data to forecast future changes and help inform conservation biology decisions […].

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Metacrine Announces Resignation of Chief Medical Officer

BioTech 365

Metacrine Announces Resignation of Chief Medical Officer Metacrine Announces Resignation of Chief Medical Officer SAN DIEGO, Dec. 27, 2021 (GLOBE NEWSWIRE) — Metacrine, Inc.

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How DNA is preserved in archaeological sediments for thousands of years

Scienmag

Sediments in which archaeological finds are embedded have long been regarded by most archaeologists as unimportant by-products of excavations. However, in recent years it has been shown that sediments can contain ancient biomolecules, including DNA. “The retrieval of ancient human and faunal DNA from sediments offers exciting new opportunities to investigate the geographical and temporal […].

DNA 83
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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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#news #biotech Lipid droplets as endogenous intracellular microlenses

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Lipid droplets as endogenous intracellular microlenses.

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Doesn’t an excessive intake of simple sugar affect higher brain function?

Scienmag

There has been a remarkable increase in intake of simple sugar (sucrose, isomerized sugar (corn syrup)) from beverages and diets in modern society. The intake of simple sugars in adolescents in which mental disorders frequently occur is higher than any other generations. Moreover, patients with mental disorders consume approximately 2-fold more sugar than age-matched healthy […].

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Relief Reports Successful Conclusion of Patent Examination Procedure for Patent Application Entitled, ‘Vasoactive Intestinal Peptide (VIP) for the Use in the Treatment of Drug-induced Pneumonitis’

BioTech 365

RELIEF THERAPEUTICS Holding AG / Key word(s): Patent 28-Dec-2021 / 07:00 CET/CEST Release of an ad hoc announcement pursuant to Art. 53 LR The issuer is solely responsible for the content of this announcement.

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Harnessing “big data” via meta-analysis of commercial Pt/C measurements for ORR

Scienmag

Developing lowcost and highly efficient electrocatalysts for oxygen reduction reaction (ORR) to replace commercial Pt/C has always been desired to greatly reduce the cost of polymer electrolyte membrane (PEM) fuel cells. The parameter of half-wave potential (E1/2) obtained from linear-sweep voltammetry (LSV) in O2-saturated acid/alkaline medium on a rotating disk electrode (RDE) is commonly used […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Trastuzumab Deruxtecan Type II Variation Application Validated by EMA for Patients with HER2 Positive Metastatic Breast Cancer Treated with a Prior Anti-HER2-Based Regimen

BioTech 365

Trastuzumab Deruxtecan Type II Variation Application Validated by EMA for Patients with HER2 Positive Metastatic Breast Cancer Treated with a Prior Anti-HER2-Based Regimen Trastuzumab Deruxtecan Type II Variation Application Validated by EMA for Patients with HER2 Positive Metastatic Breast Cancer … Continue reading →

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Simple, accurate, and efficient: Improving the way computers recognize hand gestures

Scienmag

In the 2002 science fiction blockbuster film Minority Report, Tom Cruise’s character John Anderton uses his hands, sheathed in special gloves, to interface with his wall-sized transparent computer screen. The computer recognizes his gestures to enlarge, zoom in, and swipe away. Although this futuristic vision for computer-human interaction is now 20 years old, today’s humans still […].

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Global Science City Dialogue Highlights Role of Science Cities in Fostering International Innovation and Collaboration

BioTech 365

Global Science City Dialogue Highlights Role of Science Cities in Fostering International Innovation and Collaboration Global Science City Dialogue Highlights Role of Science Cities in Fostering International Innovation and Collaboration AMSTERDAM–(BUSINESS WIRE)–#CSTB–Representatives from science and technology parks around the world … Continue reading →

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Allying meta-structures with diverse optical waveguides for integrated photonics and more

Scienmag

Comprised of judiciously engineered microscopic photonic structures with subwavelength features, the concept of metasurface and metamaterials have proven fruitful results in the realm of meta-optics. Previous research attentions are mainly devoted to applying meta-structures to tailor light in free space and develop relevant devices and applications.

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Honoring Archbishop Desmond Tutu, An Advocate and Believer in Humanity

BioTech 365

Honoring Archbishop Desmond Tutu, An Advocate and Believer in Humanity Honoring Archbishop Desmond Tutu, An Advocate and Believer in Humanity LOS ANGELES–(BUSINESS WIRE)–With deep sadness, AIDS Healthcare Foundation (AHF) marks the passing of Archbishop Desmond Tutu, an iconic freedom fighter … Continue reading →

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Newly developed injectable, adhesive surgical gel to prevent scar tissue

Scienmag

Up to 90% of patients who undergo open abdominal or pelvic surgery develop postoperative adhesions, or scar tissue. Minimally invasive laparoscopic surgical approaches can reduce the severity of the adhesions, but the scar tissue still forms. The cellular response to injury — even intentional injury, such as surgery to repair a problem — results in […].

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New tentative approval for Hospira Inc drug bortezomib

Drug Patent Watch

[![bortezomib structure]([link] Bortezomib is the generic ingredient in two branded drugs marketed by Takeda Pharms Usa, Dr Reddys Labs Ltd, and Fresenius Kabi Usa and, and is included in three…. The post New tentative approval for Hospira Inc drug bortezomib appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 40
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Hard to assess work capacity in sickness certification

Scienmag

Nearly nine out of ten doctors in primary care think a decision on sickness absence is improved if they are in touch with the patient’s employer — but only four out of ten are. A University of Gothenburg thesis highlights several challenges for doctors when certifying sickness for patients with common mental disorders. Credit: Photo: […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Patent Expirations for the Week of December 26, 2021

Drug Patent Watch

DUONEB (albuterol sulfate; ipratropium bromide) Mylan speciality lp Patent: 6,632,842 Expiration: Dec 28, 2021 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence…. The post Drug Patent Expirations for the Week of December 26, 2021 appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 40
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Scientists identify antibodies that can neutralize omicron

Scienmag

An international team of scientists have identified antibodies that neutralize omicron and other SARS-CoV-2 variants. These antibodies target areas of the virus spike protein that remain essentially unchanged as the viruses mutate. By identifying the targets of these “broadly neutralizing” antibodies on the spike protein, it might be possible to design vaccines and antibody treatments […].

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Alpha Cognition Announces Director Change and Stock Option Grant

BioTech 365

Alpha Cognition Announces Director Change and Stock Option Grant Alpha Cognition Announces Director Change and Stock Option Grant VANCOUVER, B.C.–(BUSINESS WIRE)–Alpha Cognition Inc.

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Challenging ‘rule breakers’ – children will confront their peers, but how they do so varies across cultures

Scienmag

From how we say ‘hello’ to the side of the road we drive on, all societies have norms – or ‘rules’ – that shape people’s everyday lives. Credit: PNAS From how we say ‘hello’ to the side of the road we drive on, all societies have norms – or ‘rules’ – that shape people’s everyday […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.