Drug Discovery World

OCTOBER 4, 2022

This year, genome engineering company Synthego launched a portfolio of Engineered Cell Librariesnto help improve access to CRISPR-edited cells for direct use in functional screening assays. Knockout’ mice are bred in a laboratory with specific genes silenced or ‘knocked out’.

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Gene Therapy Drugs Gene Manufacturing 52

XTalks

MAY 4, 2021

The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Genes can be switched on with a complementary tool called CRISPRon that has also been described in the paper.

DNA 98

DNA Gene Gene Silencing Genome 98

XTalks

MAY 4, 2021

The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Genes can be switched on with a complementary tool called CRISPRon that has also been described in the paper.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

JANUARY 23, 2023

Increasing interest in CRISPR-Cas gene editing systems over recent years has delivered innovative developments in precision genome engineering technologies, holding enormous potential for applications across the healthcare sector. Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.

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Gene Editing Gene Engineer DNA 52

Drug Discovery World

AUGUST 1, 2023

Another potential clinical pathway is to use engineered exogenous circRNAs to produce therapeutic proteins within target cells. One approach to using circRNA as a therapeutic molecule is to target disease-associated endogenous circRNA and mitigate its activity through the use of an RNAi therapeutic.

RNA 52

RNA Drugs Gene Silencing Vaccination 52