Drug Discovery World

JANUARY 10, 2024

ISCT, the global society of clinicians, researchers, regulators, technologists, and industry partners dedicated to the translation of cell and gene therapy (CGT) into safe and effective therapies to improve patients’ lives, aligns with the FDA in support of the need for thorough investigation and transparency.

Gene Therapy 57

Gene Therapy Genotoxicity Gene Genetics 57

Roots Analysis

MARCH 1, 2023

Genotoxicity testing refers to the evaluation of detrimental effects of chemical or physical agents on the genetic processes and related hereditary material of living cells. Mechanism of Genotoxicity / Mutagenicity The interaction of genotoxins / mutagens with the structure of DNA causes damage to the genetic material.

Genotoxicity 52

Genotoxicity DNA Genetics Bacteria 52

Drug Discovery World

MAY 10, 2023

The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issues guidelines and develops testing strategies for evaluating carcinogenicity along with other risks such as genotoxicity, immunotoxicity, and reproductive toxicity. Toxicologic Pathology. 2011;39(4):716-744.

Bioassay 52

Bioassay Genotoxicity Drugs In-Vivo 52

The Pharma Data

MAY 13, 2021

Exposure to sorbitol during lactation causes metabolic alterations and genotoxic effects in rat offspring. Neural and Genetic Correlates of the Social Sharing of Happiness. Opiate-like effects of sugar on gene expression in reward areas of the rat brain. 2012;109(16):5984-5988. DOI: 10.1073/pnas.1120794109. 1120794109.

Insulin 52

Insulin Production Hormones Medicine 52