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UK agency pilots biobank to study links between genetics and drug side effects

Pharmaceutical Technology

The Medicines and Healthcare products Regulatory Agency (MHRA) aims to launch a pilot genetic biobank that will gather patient data to associate drug-related adverse events to their genetic makeup. The Yellow Card biobank will launch as a joint venture with the UK-government funded entity Genomics England on June 1.

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Earth BioGenome Project begins genome sequencing in earnest

Scienmag

A global effort to map the genomes of all plants, animals, fungi and other microbial life on Earth, is entering a new phase as it moves from pilot projects to full-scale production sequencing. This new phase of the The Earth BioGenome Project, or EBP, is marked with a collection of papers published this week (Jan. […].

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Junk DNA: How the dark genome is changing RNA therapies

Drug Discovery World

Decoding ‘junk DNA’ The Human Genome Project and subsequent studies discovered that most of our DNA (approximately 98%) does not actually code for proteins, with humans having approximately 20,000 tox 25,000 protein-coding genes. This leads to potentially severe, debilitating and unbearable toxicities for patients.

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New wheat and barley genomes will help feed the world

Scienmag

Researchers from the 10+ Wheat Genomes Project, led by Professor Curtis Pozniak (University […].

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Q&A: Gene therapy opportunities from long-read sequencing 

Drug Discovery World

To develop safe and effective gene therapies, researchers need confidence that genomic data is both complete and accurate. This considerable magnitude of difference in read length affords researchers a more complete and accurate view of genomic variation. For years now the UK has been somewhat of a leader in genomic research.

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Can Singapore become a global hub for biotech?

Drug Discovery World

Singapore is also leading the way in genomics, having founded The Genome Institute of Singapore as far back as 2000. Dr Gokhale expands on the country’s leadership role: “Singapore is a great example of integration of genomic medicine in healthcare via population scale research.

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Exa-Cel CRISPR Gene Therapy for Sickle Cell Disease Deemed Safe by FDA Advisory Panel

XTalks

CRISPR works as genetic scissors to edit parts of the genome. The companies used data from the 1,000 Genomes Project but from that, only 61 datasets made the cut to encompass the ideal patient population. “I The CRISPR-Cas9 gene editing system was first discovered to be endogenous in bacteria.