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A new dawn of the genomic age: five areas set to be transformed in 2023

pharmaphorum

Protein prediction algorithms will reach their potential Proteomics has long been hindered by inaccurate or incomplete RNA sequences – with resultant predictive models built from RNA proving inaccurate. Just one mutation can lead to a complete change in protein formation. So, when it comes to proteomics, accuracy is vital.

Genome 129
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Realising the promise of genomic testing across oncology

pharmaphorum

Unlocking the secrets of the human genome has long been an ambitious pursuit for researchers around the world. Today, the landscape of genomic testing and research is rapidly progressing, with significant scientific and technological advances driving a paradigm shift in the understanding of oncology at a molecular level.

Genome 52
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Junk DNA: How the dark genome is changing RNA therapies

Drug Discovery World

Decoding ‘junk DNA’ The Human Genome Project and subsequent studies discovered that most of our DNA (approximately 98%) does not actually code for proteins, with humans having approximately 20,000 tox 25,000 protein-coding genes. This leads to potentially severe, debilitating and unbearable toxicities for patients.

RNA 52
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Searching for answers in rare epilepsy

pharmaphorum

Everything the 100,000 Genomes Project does has to be rubber-stamped by the patients”. At the time, the Sanger Institute was working on the Deciphering Developmental Disorders study (DDD), which looked at the approximately 1-2% of the genome that is responsible for making proteins in patients with rare diseases.

Genome 103
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Searching for answers in rare epilepsy

pharmaphorum

Everything the 100,000 Genomes Project does has to be rubber-stamped by the patients”. At the time, the Sanger Institute was working on the Deciphering Developmental Disorders study (DDD), which looked at the approximately 1-2% of the genome that is responsible for making proteins in patients with rare diseases.

Genome 80
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The Biotech Effect

Pharmaceutical Technology

. “The inherent advantages of biopharma are that it allows you to pursue therapies against targets that are not small molecule therapies, for example by targeting protein-protein interactions and targeting GPCRs (G-protein coupled receptors),” he says. “Biotechnology has exploded across the industry. .

Antibody 130
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Where is the drug discovery expertise happening in the UK?

Drug Discovery World

The country’s pioneering genomics research, crucial for future drug discovery, is demonstrated by institutes like the Wellcome Sanger Institute and projects like the 100,000 Genomes Project.

Drugs 75