DNA and Genome - Clinical Research Informer

Tome Biosciences debuts with $213M and a new way to edit the genome

Bio Pharma Dive

DECEMBER 12, 2023

Based on the work of MIT scientists, the well-funded startup is developing ways to insert large sizes of genetic material anywhere in the genome without damaging or breaking DNA.

Genome

Genome Genomics DNA Genetics

Tome acquires startup Replace, gaining new genome editing tools

Bio Pharma Dive

JANUARY 2, 2024

The deal is the second startup sale engineered by University of California, Berkeley scientist Shakked Halperin, and gives Tome a way to insert or delete small DNA sequences into the genome.

Genome

Genome Genomics DNA Engineer

How rAAV genome sequencing uncovers transgene integrity

Drug Discovery World

APRIL 24, 2024

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. The post How rAAV genome sequencing uncovers transgene integrity appeared first on Drug Discovery World (DDW). The event will be supported by Oxford Nanopore Technologies.

Genome

Genome Genomics DNA Gene Therapy

rAAV Genome sequencing uncovers transgene integrity and packaging impurities

Drug Discovery World

APRIL 16, 2024

Attendees will hear how library preparation, assessed data quality, and generated important rAAV metrics such as integrity of DNA cargo, truncation events, chimeric transgenes, and levels of co-packaged impurities were performed. A live Q&A session follows the webinar presentation.

Packaging

Packaging Packaging Genome Genomics

Junk DNA: How the dark genome is changing RNA therapies

Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. In actuality, the protein-coding portion of our genome is comparable in identity and number with the humble fruit fly or worm.

RNA

RNA Genome Genomics DNA

Hopewell Therapeutics raises funds for genomic medicines development

Pharmaceutical Technology

JUNE 8, 2023

Biotechnology company Hopewell Therapeutics has raised $25m in seed financing to accelerate the development of next-generation lipid nanoparticles for targeted delivery of genomic medicines. Hopewell Therapeutics is engaged in discovering, synthesising and developing advanced ttLNPs to provide next-generation genomic medicines.

Genome

Genome Genomics Medicine Development

DNA project gives scientists diverse genome for comparison

Medical Xpress

MAY 14, 2023

For two decades, scientists have been comparing every person's full set of DNA they study to a template that relies mostly on genetic material from one man affectionately known as "the guy from Buffalo."

DNA

DNA Scientist Genome Genomics

STAT+: Chinese DNA giant’s U.S. affiliate looks to rival Illumina, touting $100 genome and high-power sequencers

STAT News

FEBRUARY 7, 2023

Complete Genomics, a U.S. firm affiliated with Chinese sequencing giant BGI, on Tuesday announced plans to launch a new line of sequencers it says can decode DNA in larger amounts — and at lower costs — than any instrument on the market.

Genome

Genome Genomics DNA Marketing

Novel technique opens up new possibilities in synthetic genomics

Drug Discovery World

DECEMBER 29, 2023

A new technique to clone and reassemble DNA could simplify and lower the cost of making synthetic chromosomes, according to its creators at University of Southern California (USC) Dornsife. The thing about most synthetic genomics research is that it involves building chromosomes or genomes from scratch using chemically synthesised DNA pieces.

Genome

Genome Genomics DNA Scientist

Oncotarget: Genome wide DNA methylation landscape reveals glioblastoma’s influence

Scienmag

JULY 4, 2021

These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells Credit: Correspondence to – Mahua Dey – dey@neurosurgery.wisc.edu Oncotarget published “Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells” (..)

Genome

Genome Genomics DNA Medicine

Study: Metformin's impact on aging and longevity through DNA methylation

Medical Xpress

FEBRUARY 22, 2023

A new research paper was published in Aging, titled "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

DNA

DNA Genome Genomics Research

STAT+: ??Genomics is racing toward a $100 genome. Are we ready for it?

STAT News

JULY 27, 2022

As the cost of DNA sequencing plummets, we’re fast approaching a point when decoding a human genome could cost $100 — about as much as the average American’s weekly grocery store run. Health systems are preparing to test programs that could lead to the use of whole-genome screening in millions of newborns.

Genome

Genome Genomics DNA Genetics

UK scientists say they have found cancer driver in junk DNA

pharmaphorum

JULY 20, 2022

It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.

DNA

DNA Scientist Genome Genomics

STAT+: Upstart Element ratchets up race for cheaper DNA sequencing with a $200 genome

STAT News

JANUARY 11, 2023

But genomics startup Element Biosciences on Wednesday announced it can now read a whole human genome for as little as $200 — the cost of a couple trips to the grocery store. SAN FRANCISCO — Decoding the billions of chemical letters that help shape who we are once cost a fortune.

Genome

Genome Genomics DNA Genetics

Novel artificial genomic DNA can replicate and evolve outside the cell

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

DNA

DNA Gene Expression Genome Genomics

Verge Genomics’ Alice Zhang on a young biotech founder’s ‘superpower’ and going from target to drug

Bio Pharma Dive

OCTOBER 25, 2022

“Every struggle that I've had has woven a sense of persistence into my DNA,” said Zhang, in a wide-ranging interview about leading a biotech startup as a young CEO.

Genome

Genome Genomics DNA Drugs

DNA analysis could pinpoint ‘long haulers’ among COVID-19 patients

Outsourcing Pharma

DECEMBER 23, 2020

The analytical tool, developed via Bionano Genomics, maps structural variations in DNA that are known to cause disease and are tied to symptom severity.

DNA

DNA Genome Genomics Development

‘Junk’ DNA could lead to cancer by stopping copying of DNA

Scienmag

JULY 19, 2022

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate.

DNA

DNA Genome Genomics Scientist

First genome-wide ancient human DNA from Sudan shines new light on Nile Valley past

Scienmag

DECEMBER 17, 2021

The first genome-wide ancient human DNA data from Sudan reveals new insights into the ancestry and social organization of people who lived more than 1,000 years ago in the Nile Valley, an important genetic and cultural crossroads.

DNA

DNA Genome Genomics Genetics

Study suggests DNA sequencing could reduce infant deaths, often caused by genetic disease

STAT News

FEBRUARY 9, 2023

Researchers who believe genomics can transform human health love to recount success stories. Or the baby girl who could have had a life-threatening reaction to anesthesia had researchers not sequenced her DNA ahead of time.

Genetic Disease

Genetic Disease DNA Genetics Genome

STAT+: With rivals on its heels, Illumina launches a new line of high-end DNA sequencers

STAT News

SEPTEMBER 30, 2022

SAN DIEGO — After a steep drop in its stock price and with mounting competition from rivals, genomics giant Illumina on Thursday launched a new line of high-powered DNA sequencers, ratcheting up the race to read genetic information accurately and cheaply. Continue to STAT+ to read the full story…

DNA

DNA Genome Genomics Genetics

Broken String Biosciences bags $15M to make genome editing safer

BioPharma Reporter

SEPTEMBER 19, 2023

The UK startup Broken String Biosciences has raised a $15 million Series A round to fund the development of a DNA sequencing platform that maps off-target DNA breaks resulting from genome editing technology.

Genome

Genome Genomics DNA Development

World’s largest catalogue of ocean DNA could boost drug discovery

Drug Discovery World

JANUARY 23, 2024

” The ability to collect and analyse such a new wealth of ocean data comes from major developments in DNA sequencing technology and computational power. The post World’s largest catalogue of ocean DNA could boost drug discovery appeared first on Drug Discovery World (DDW).

DNA

DNA Drugs Gene Scientist

STAT+: Pacific Biosciences, known for niche DNA sequencing, looks to rival Illumina with new product launch

STAT News

OCTOBER 25, 2022

firm best known for its niche approach to DNA sequencing, on Tuesday announced plans to launch a new product that will put the company in direct competition with genomics juggernaut Illumina. The new DNA sequencer, dubbed Onso, reads the genome in small pieces and uses software to stitch that information together.

DNA

DNA Production Genome Genomics

As the Smithsonian wraps a landmark genome exhibit, leaders in the field reflect on what’s changed

STAT News

AUGUST 17, 2022

When the Smithsonian National Museum of Natural History opened its genomics exhibit in 2013, the field was just celebrating the 10th anniversary of the completed Human Genome Project. Sequencing that first genome cost over $500 million. The genomes since cost $10,000. The development of CRISPR-Cas9 landed a Nobel Prize.

Genome

Genome Genomics Genome Project DNA

A new dawn of the genomic age: five areas set to be transformed in 2023

pharmaphorum

JANUARY 26, 2023

2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.

Genome

Genome Genomics Genome Project Genetics

Cancer Grand Challenge: Solving the mystery of DNA rings

Scienmag

JUNE 16, 2022

In 2014, Professor Anton Henssen discovered something unusual in the cells of pediatric cancer patients: small rings of DNA, which meant that part of the genetic information was no longer packaged in the chromosomes as normal. It was very clear that the rings disturbed the rest of the genome so much that the children’s cells […].

DNA

DNA Packaging Packaging Genome

Genome-wide CRISPR screens identify PARP inhibitor sensitivity and resistance in prostate cancer

Medical Xpress

APRIL 4, 2023

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

Genome

Genome Genomics DNA Gene

Investment fuels AI-driven development of breakthrough genomic medicines

pharmaphorum

OCTOBER 12, 2022

David Del Bourgo (CEO and co-founder, Whitelab Genomics) has always been passionate about introducing disruptive, innovative technologies to markets. We founded Whitelab Genomics after realising the potential to use data, data science, and AI in a more systematic way to develop genomic therapies,” Del Bourgo says.

Genome

Genome Genomics Medicine Development

STAT+: Ahead of genome summit in London, questions linger about CRISPR baby scandal

STAT News

MARCH 3, 2023

Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry.

Genome

Genome Genomics Gene Editing Genetic Disease

Deluge of DNA changes drives progression of fatal melanomas

Scienmag

MARCH 22, 2021

Credit: WEHI, Australia Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

DNA

DNA Genome Genomics Research

Why genomic healthcare data matters in the development of new therapies

Drug Discovery World

NOVEMBER 7, 2022

Genomic healthcare data is critical to identify disease risk, ancestry, traits and response to medicines and aids in the development of new targeted therapies – precision medicines. In April 2003, after its launch in October 1990, the project was completed, generating the first sequence of the human genome. The origins .

Genome

Genome Genomics Development Genetics

STAT+: England to sequence genomes of 100,000 newborns, to try to catch illness earlier

STAT News

DECEMBER 12, 2022

LONDON — England is launching a pilot program sequencing the genomes of up to 100,000 newborns to see if such a strategy can speed up the detection of genetic illnesses. The Newborn Genomes Programme will scan DNA for mutations that can cause some 200 conditions.

Genome

Genome Genomics Genetic Disease Genetics

Junk DNA could lead to cancer, study says

Drug Discovery World

JULY 19, 2022

Non-coding or ‘junk’ DNA could contribute to the development of certain cancers due to how it disrupts the replication of the genome, scientists have discovered. . A team from The Institute of Cancer Research (ICR), London reconstituted the entire process of DNA replication in a test tube in order to understand it more completely.

DNA

DNA Genome Genomics Genetics

Researchers discover mechanism linking mutations in the ‘dark matter’ of the genome to cancer

Scienmag

JUNE 13, 2022

For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish.

Genome

Genome Genomics DNA Containment

HitGen and SGC enter drug discovery partnership

Pharmaceutical Technology

SEPTEMBER 29, 2023

HitGen and the Structural Genomics Consortium entered a collaboration to discover drugs based on a DNA-encoded library (DEL).

DNA

DNA Genome Genomics Drugs

Moderna to acquire OriCiro Genomics

BioPharma Reporter

JANUARY 5, 2023

mRNA specialist Moderna will acquire OriCiro Genomics K.K, a pioneer in cell-free DNA synthesis and amplification technologies, for $85m.

Genome

Genome Genomics DNA Development

Partners tackle global health challenges through genomics

Drug Discovery World

JULY 19, 2023

UK-based precision medicine software provider Lifebit has agreed partnerships with two population genomic initiatives in Mexico and Brazil to help diversify genomic research and reduce health inequality in Latin America. The post Partners tackle global health challenges through genomics appeared first on Drug Discovery World (DDW).

Genome

Genome Genomics Genetics DNA

Princeton-led study of DNA repair boosts prospects for gene editing technology

Scienmag

OCTOBER 20, 2021

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all.

DNA

DNA Gene Editing Genome Genomics

Opinion: Where are the guidelines for the production of animals with intentional genomic alterations?

STAT News

APRIL 17, 2023

But with the advent of genetic engineering, genes encoding favorable traits in one species (say, that hornless cow) could be spliced into the genomes of other animals. Read the rest…

Genome

Genome Genomics Genetic Engineering Production

Partners working to realise the future of genomic medicine

Drug Discovery World

SEPTEMBER 25, 2023

CRISPR gene editing companies Integrated DNA Technologies (IDT) and Aldevron have inked a new global distribution agreement to expand CRISPR products for cell and gene therapy customers. The post Partners working to realise the future of genomic medicine appeared first on Drug Discovery World (DDW).

Genome

Genome Genomics Gene Editing Medicine

STAT+: New CRISPR startup, drawing big-name backers, seeks to fix diseases caused by large DNA errors

STAT News

SEPTEMBER 20, 2022

A new CRISPR startup — backed by some big names in venture capital — is planning to develop gene-editing treatments that can insert a genetic sequence of any length, at any location in the DNA strand, according to industry insiders and documents.

DNA

DNA Gene Editing Genome Genomics

Probe of DNA repeats reveals genetic link to schizophrenia

Scienmag

MAY 11, 2022

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual’s risk of developing schizophrenia.

DNA

DNA Genetics Genome Genomics

Verge Genomics takes AI-sourced drug for ALS into clinic

pharmaphorum

OCTOBER 31, 2022

Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. The post Verge Genomics takes AI-sourced drug for ALS into clinic appeared first on.

Genome

Genome Genomics Drugs RNA

Tome Biosciences debuts with $213M and a new way to edit the genome

Tome acquires startup Replace, gaining new genome editing tools

Trending Sources

How rAAV genome sequencing uncovers transgene integrity

rAAV Genome sequencing uncovers transgene integrity and packaging impurities

Junk DNA: How the dark genome is changing RNA therapies

Hopewell Therapeutics raises funds for genomic medicines development

DNA project gives scientists diverse genome for comparison

STAT+: Chinese DNA giant’s U.S. affiliate looks to rival Illumina, touting $100 genome and high-power sequencers

Novel technique opens up new possibilities in synthetic genomics

Oncotarget: Genome wide DNA methylation landscape reveals glioblastoma’s influence

Study: Metformin's impact on aging and longevity through DNA methylation

STAT+: ??Genomics is racing toward a $100 genome. Are we ready for it?

UK scientists say they have found cancer driver in junk DNA

STAT+: Upstart Element ratchets up race for cheaper DNA sequencing with a $200 genome

Novel artificial genomic DNA can replicate and evolve outside the cell

Verge Genomics’ Alice Zhang on a young biotech founder’s ‘superpower’ and going from target to drug

DNA analysis could pinpoint ‘long haulers’ among COVID-19 patients

‘Junk’ DNA could lead to cancer by stopping copying of DNA

First genome-wide ancient human DNA from Sudan shines new light on Nile Valley past

Study suggests DNA sequencing could reduce infant deaths, often caused by genetic disease

STAT+: With rivals on its heels, Illumina launches a new line of high-end DNA sequencers

Broken String Biosciences bags $15M to make genome editing safer

World’s largest catalogue of ocean DNA could boost drug discovery

STAT+: Pacific Biosciences, known for niche DNA sequencing, looks to rival Illumina with new product launch

As the Smithsonian wraps a landmark genome exhibit, leaders in the field reflect on what’s changed

A new dawn of the genomic age: five areas set to be transformed in 2023

Cancer Grand Challenge: Solving the mystery of DNA rings

Genome-wide CRISPR screens identify PARP inhibitor sensitivity and resistance in prostate cancer

Investment fuels AI-driven development of breakthrough genomic medicines

STAT+: Ahead of genome summit in London, questions linger about CRISPR baby scandal

Deluge of DNA changes drives progression of fatal melanomas

Why genomic healthcare data matters in the development of new therapies

STAT+: England to sequence genomes of 100,000 newborns, to try to catch illness earlier

Junk DNA could lead to cancer, study says

Researchers discover mechanism linking mutations in the ‘dark matter’ of the genome to cancer

HitGen and SGC enter drug discovery partnership

Moderna to acquire OriCiro Genomics

Partners tackle global health challenges through genomics

Princeton-led study of DNA repair boosts prospects for gene editing technology

Opinion: Where are the guidelines for the production of animals with intentional genomic alterations?

Partners working to realise the future of genomic medicine

STAT+: New CRISPR startup, drawing big-name backers, seeks to fix diseases caused by large DNA errors

Probe of DNA repeats reveals genetic link to schizophrenia

Verge Genomics takes AI-sourced drug for ALS into clinic

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