pharmaphorum

FEBRUARY 10, 2022

In its annual results statement, AZ said that it took the decision on the back of data showing that a third dose of Vaxzevria increased the immune response to new variants, including Omicron which is currently driving new COVID-19 cases around the world. ” Vaxzevria added almost $4 billion to its revenues last year, including $1.8

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Vaccination Vaccine Development Immune Response 52

pharmaphorum

AUGUST 10, 2021

The comments came on the German biotech’s second-quarter results call, during which BioNTech raised its forecasts for revenues it will book from sales of the vaccine to €15.9 billion in sales this year, although analysts have suggested this could be a conservative estimate. Pfizer said last month it may generate $33.5

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Vaccination Vaccine Immune Response Sales 115

pharmaphorum

DECEMBER 4, 2020

Pfizer will pay up to $45 million in development related milestone payments and up to $143 million if the vaccine hits early sales targets. VLA15 has demonstrated a promising immune response and safety data in pre-clinical and clinical studies so far.

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Vaccination Vaccine Bacterium Protein 119

Pharmaceutical Technology

OCTOBER 28, 2022

What’s more, VAX-24 achieved a higher immune response to 16 of the 20 serotypes it shares with Prevnar 20. According to GlobalData, Pharmaceutical Technology’s parent company, Prevnar 13 and Vaxneuvance are forecasted to have global sales of $7.26 VAX-24 has forecasted sales of $21 million in the same year.

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Vaccination Vaccine Marketing Bacteria 162

pharmaphorum

DECEMBER 6, 2022

Moderna is also suing Pfizer and BioNTech in Germany, and if it wins in both suits could claim a royalty on COVID-19 vaccine sales, although these have been falling and are expected to fall further if the pandemic continues to abate.

Vaccination 89

Vaccination Vaccine Immune Response Sales 89

pharmaphorum

MARCH 17, 2022

After dosing, the LNPs deliver the mRNA sequence into cells, which is then used by cellular machinery to manufacture the viral protein and stimulate an immune response. Pfizer made $36 billion in sales from Comirnaty last year, and is expecting to shift another $32 billion-worth in 2022.

Vaccination 52

Vaccination Vaccine Sales Immune Response 52

pharmaphorum

OCTOBER 2, 2020

Vaccibody, which is also entitled to tiered royalties on sales of any marketed products, will develop the DNA-based individualised neoantigen vaccines until the end of phase 1b. NEO, which is designed to be produced on-demand according to the neoantigen profile of an individual patient and produces an immune response that attacks the tumour.

Vaccination 59

Vaccination Vaccine Immune Response Drugs 59

pharmaphorum

AUGUST 5, 2022

It reckons that its antibodies will be able to target the underlying cause of autoimmune diseases, unlike current therapies such as steroids or TNF and interleukin inhibitors that while effective are non-selective, so suppress both appropriate and inappropriate immune responses.

Antibody 97

Antibody Immune Response Development Medicine 97

XTalks

AUGUST 14, 2023

XTALKS WEBINAR: Cancer Immunotherapy: Exploring Imaging as a Catalyst to Immune Response Prediction Live and On-Demand: Wednesday, September 27, 2023, at 2pm EDT (11am PDT) Register for this free webinar to discover the present and transformative impact of predictive biomarkers on immunotherapy response.

FDA Approval 97

FDA Approval Antibody Immune Response Drugs 97

pharmaphorum

AUGUST 26, 2022

Among the claims is that Comirnaty was developed using a chemical modification to prevent causing an unwanted immune response in patients which was discovered by Moderna scientists, and that the use of a lipid nanoparticle formulation also infringes its intellectual property.

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Vaccination Vaccine Sales Immune Response 59

World of DTC Marketing

APRIL 11, 2021

Both Pfizer and Moderna stand to make billions, and even though J&J said they would not make money on the first batch, they are already positioning yearly Covid Vaccine shots that could net them billions in sales. Do Lockdowns Work?

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Vaccination Vaccine Clinical Trials Clinical Trials 303

pharmaphorum

SEPTEMBER 8, 2021

Kadmon claimed approval for Rezurock (belumosudil) in July as a treatment for chronic graft versus host disease (GVHD) – a common and often fatal complication that can follow a bone marrow transplant and which occurs when the donated cells mount an immune response against the transplant recipient’s tissues and organs.

Drugs 52

Drugs Sales Immune Response Marketing 52

pharmaphorum

JUNE 22, 2022

Merck also sells an older shot called Pneumovax 23, which covers 23 serotypes but is based on an older polysaccharide technology that does not stimulate the immune response as strongly as the newer conjugate vaccines. Sales dipped to $5.2 billion.

Vaccination 52

Vaccination Vaccine Immune Response Sales 52

XTalks

MAY 2, 2024

The firm predicts sales of KarXT could reach $2.8 Current drugs on the market for schizophrenia include Lundbeck and Otsuka’s Rexulti (brexpiprazole) and Eli Lilly’s Prozac (fluoxetine), but these drugs derive the majority of their sales from other conditions, including severe forms of depression or Alzheimer’s agitation. billion ($1.5

Drugs 52

Drugs FDA Approval Sales Vaccination 52

pharmaphorum

SEPTEMBER 29, 2022

The disorder – driven by type 2 inflammation characterised by an antibody-based immune response – causes hard lumps or nodules to form on the skin that are so itchy they can lead patients to scratch themselves to the point of bleeding or pain.

Drugs 69

Drugs Immune Response Allergies Sales 69

The Pharma Data

JANUARY 22, 2021

An Ohio State University review of 49 vaccine studies dating back 30 years examined how stress, depression and healthy behaviors, such as exercise, can affect immune response to a vaccine. “What we see is that stress can delay your antibody response to the vaccine,” Kiecolt-Glaser said.

Immune Response 52

Immune Response Vaccination Vaccine Antibody 52

pharmaphorum

JANUARY 17, 2023

It launched a strategic review shortly afterwards, looking into a possible sale of the business, which was left with around $63 million in cash and liquid investments, and preclinical-stage ROCK2 and aldosterone synthase inhibitors. Darrell Irvine.

Immune Response 77

Immune Response Trials Engineer Sales 77

The Pharma Data

NOVEMBER 17, 2020

t for the treatment of autoimmune diseases , which occur when the body’s immune system attacks its own cells and tissues as foreign invaders. . While the antibody responsible for immune-mediated diseases is yet to be identified, they are thought to be regulated by an aberrant immune response. Source link.

Immune Response 52

Immune Response Licensing Licensing Sales 52

pharmaphorum

AUGUST 12, 2021

The AstraZeneca shot has been the mainstay of the UK vaccination and is provided at cost – just £2 per dose – although the drugmaker said last month that it was making a loss on sales due to high R&D costs. The Johnson & Johnson vaccine is also supplied on a no-profit basis.

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Vaccination Vaccine Immune Response Sales 111

The Pharma Data

JANUARY 12, 2021

Ben-Moshe told BioSpace that BND-22 differs from traditional immunotherapy in that it can elicit a more total immune response. . “It It is a new immune checkpoint that is expressed on three different immune cells: Macrophages, [Natural Killer] NK cells, and T cells. [It]

Immune Response 52

Immune Response Clinical Trials Clinical Trials Development 52

pharmaphorum

JANUARY 4, 2023

They both also include tiered royalties on sales of any products emerging from the partnerships. The hypothesis is that it will induce immune tolerance by stimulating anti-inflammatory regulatory T- (Treg) cells and cytokines that dampen down the immune response.

Immune Response 52

Immune Response Engineer Licensing Licensing 52

pharmaphorum

DECEMBER 21, 2020

Each programme includes undisclosed upfront and milestone payments plus royalties on sales, with Merck indicating in a statement that it will be funding the research. Just a few weeks ago, Merck (known as MSD outside North America) paid $425 million to get hold of OncoImmune.

Immune Response 53

Immune Response Sales Antibody Pharma Companies 53

pharmaphorum

FEBRUARY 9, 2022

Closely related to this is the fact that global spending on oncology drugs reached $164 billion in 2020, with drug sales growing at a compound annual growth rate of 14.3% While therapeutic cancer vaccines are able to help the body identify particular proteins expressed by cancer cells and then to instigate an immune response.

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Vaccination Vaccine Clinical Trials Clinical Trials 129

pharmaphorum

FEBRUARY 14, 2022

billion in sales last year, slightly down as a result of the pandemic. Like Shingrix, CRV-101 is a subunit vaccine based on the glycoprotein E (gE) antigen of the herpes zoster virus, delivered alongside an adjuvant to boost the immune response.

Vaccination 52

Vaccination Vaccine Immune Response Trials 52

XTalks

JULY 8, 2021

Patients with severe COVID-19 often have an overactivation of the immune system, which involves the increased release of cytokines (cytokine release syndrome) such as IL-6. By blocking the cytokine from binding to its receptor, the hyperactive immune response can be tamed. Actemra sales reached $3.12

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Doctors Doctor Manufacturing Drugs 98

pharmaphorum

SEPTEMBER 30, 2021

Prevnar 20 was approved in June, and provides protection against 20 pneumococcal serotypes, seven more than the current Prevnar 13 shot that made almost $6 billion in sales for Pfizer last year, dominating a market worth around $8 billion. Vaxneuvance – which targets 15 serotypes – is key to Merck’s plan to boost market share.

Vaccination 52

Vaccination Vaccine Immune Response Marketing 52

The Pharma Data

JANUARY 12, 2021

“The T-cell and NK-cell target discovery approach complements our portfolio aimed at turning cold tumors hot and redirecting the innate immune system to elicit a sustained and durable immune response against tumors. KSQ is also eligible to receive tiered royalties on net sales of each approved product.

Development 52

Development Research In-Vivo Genome 52

The Pharma Data

JUNE 30, 2021

Yasmin Parr’s study of FeLV shows that the outcome of FeLV infection is influenced by the host immune response, with progressively infected cats, so cats whose conditions are worsening, having weaker immune responses. “In billion euros in 2020 and presence in more than 150 countries.

Scientist 52

Scientist Immune Response Antibody Development 52

XTalks

MARCH 8, 2024

According to Amgen’s last earnings report , Prolia sales increased 12 percent last year to more than $4 billion, and Xgeva’s jumped five percent from last year to $2.1 Amgen also claimed that Sandoz failed to provide information about its biosimilar manufacturing process as required by law.

Drugs 59

Drugs FDA Approval Production Immune Response 59

pharmaphorum

AUGUST 16, 2020

Last month, interim results from a phase 1/2 trial of ChAdOx1 were published in The Lancet and showed the jab was tolerated and generated immune responses against the SARS-CoV-2 virus in all vaccinated participants.

Vaccination 111

Vaccination Vaccine Immune Response Trials 111

pharmaphorum

NOVEMBER 24, 2020

Sputnik V’s developers say its high level of efficacy comes from the use of two different adenoviral vectors which “allows for a stronger and longer-term immune response as compared to the vaccines using one and the same vector for two doses.”. The next analysis for Sputnik V will be made when there are 78 confirmed coronavirus cases.

Vaccination 111

Vaccination Vaccine Immune Response Marketing 111

pharmaphorum

JANUARY 5, 2021

First-line immunotherapy for NSCLC is dominated by Merck & Co’s PD-1 inhibitor Keytruda (pembrolizumab), transforming the prospects of some patients and propelling the drug to multibillion-dollar sales.

Immune Response 52

Immune Response FDA Approval Drugs Sales 52

XTalks

JULY 8, 2021

Patients with severe COVID-19 often have an overactivation of the immune system, which involves the increased release of cytokines (cytokine release syndrome) such as IL-6. By blocking the cytokine from binding to its receptor, the hyperactive immune response can be tamed. Actemra sales reached $3.12

Doctors 52

Doctors Doctor Manufacturing Drugs 52

pharmaphorum

MARCH 28, 2022

billion to the company’s revenues, and the company has previously said it expects sales to be around the same level in 2022. The antibody made a substantial contribution to GSK’s top-line last year, adding around $1.25 AZ’s Evusheld approved in Europe. “Increasing COVID-19 cases, driven by the highly-transmissible BA.2

Antibody 52

Antibody Immune Response Regulation Sales 52

The Pharma Data

DECEMBER 23, 2020

All 38 subjects who were evaluable for immunogenicity had balanced cellular and humoral immune responses following the second dose of INO-4800. The antigen is processed naturally in the cell and triggers the desired T cell and antibody-mediated immune responses. About INOVIO.

DNA 40

DNA Vaccination Vaccine Immune Response 40

XTalks

MAY 1, 2023

At its peak sales, Qalsody is expected to generate around $300 million for Biogen. By blocking CD40 receptors on antigen-presenting cells such as dendritic cells, B cells and macrophages, tegoprubart promotes the development of CD4+ T cells to T regulatory cells, which suppresses the immune response.

FDA Approval 89

FDA Approval Gene Genetics Protein 89

The Pharma Data

OCTOBER 27, 2020

Mirati will not receive any proceeds from the sale of common stock by the selling stockholder. Sitravatinib is an investigational spectrum-selective inhibitor of receptor tyrosine kinases (RTK) designed to enhance immune responses through the inhibition of immunosuppressive signaling.

Sales 52

Sales Immune Response Clinical Development Development 52