Remove tag target-discovery
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Cancer research drugs: Where is the innovation?

Drug Discovery World

The last month has seen huge strides forward in our understanding of cancers, particularly in how they develop resistance to therapies and how we can ‘outsmart’ them using gene editing or different therapeutic pathways, but also how we can better target drugs to individuals and accurately predict treatment outcomes.

Drugs 52
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Epigenetics discovery could lead to new class of cancer drugs

Drug Discovery World

New understanding of epigenetics It has been known for more than 20 years that the enzymes placing H3K4me3, a chemical tag added to DNA, are crucial for normal cell development, as well as being linked to leukaemia, breast, bowel and pancreatic cancers.

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Almirall and IRB Barcelona team up to tackle skin disease

pharmaphorum

The use of monovalent degraders, which enable the targeted degradation of disease-relevant proteins, offers a new avenue to reach tissue that cannot be targeted with conventional therapeutic agents. Researchers at Almirall have identified several proteins whose abnormal function is associated with inflammatory immune skin diseases.

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Sponsored content: Why choose Bethyl antibodies for your R&D

Drug Discovery World

For over 50 years, Bethyl Laboratories (now a Fortis Life Sciences brand) has been dedicated to improving lives by supporting scientific discovery through qualified antibody products and custom services. This pillar takes advantage of the unique biology associated with some protein targets. Pillar 5: Protein OE/Epitope Tags.

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Scientists uncover secret to success in new class of cancer drugs

Drug Discovery World

One enduring problem for the field has been the fact that some of these drugs bind tightly to cereblon, yet fail to cause sufficient degradation of their protein targets. . The post Scientists uncover secret to success in new class of cancer drugs appeared first on Drug Discovery World (DDW).

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Potential disease-modifying therapy for Parkinson’s disease

Drug Discovery World

Importance of healthy mitochondrial function Dysfunctional mitochondria are usually tagged for removal via mitophagy with a protein ‘flag’ called ubiquitin. This research provides compelling evidence that USP30 is a promising therapeutic target for PD, where there is a pressing need for disease-modifying treatments.”

In-Vivo 52
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First gene therapy trial for Hunter syndrome opens in Manchester, UK

Drug Discovery World

The children will continue to receive enzyme replacement therapy during treatment, but once the gene therapy begins to work, the research team say part of the trial aims to remove the need for weekly enzyme replacement therapy over the child’s lifetime, while the other aim is to safely target the brain disease suffered by these patients.