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Cell and Gene Therapy Bioassay – A Prerequisite for the ATMPs Development

Roots Analysis

Bioassay – A Prerequisite for the Cell and Gene Therapy Development. Therefore, increase in development of cell and gene therapy domain has led to the rise in demand of bioassay services for cell and gene therapy. Bioassays are biochemical procedures that are used to evaluate the potency, purity and efficacy of a drug substance.

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How ML and automation are changing the future of protein therapeutics

Drug Discovery World

Kristen Hopson , Vice President of Preclinical Discovery and Development at Generate Biomedicines, and Yup Liu , Associate Director, HTS at Generate Biomedicines, reflect on the impact of AI, ML cloud computing, and advances in laboratory automation and high-throughput screening (HTS) on life science research.

Protein 52
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Reimagining cell engineering with picodroplet microfluidic technology

Drug Discovery World

This paid-for advertorial by Sphere Fluidics appeared in the SLAS 2023 Supplement, Volume 24 – Issue 1, Winter 2022/2023 Cell engineering is being held back by lengthy and complicated multi-step workflows. Sphere Fluidics’ Cyto-Mine ® system offers a streamlined, automated solution to this challenge using picodroplet microfluidic technology.

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What to expect from PEGS Europe 2023: Day 2

Drug Discovery World

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Kielczewska will present: ‘Discovery of antibody-based therapeutics to challenging targets: Platform considerations’.

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Reflecting on PEGS Europe 2023 

Drug Discovery World

Panel moderators included Ulf Grawunder from T-CURX and Astero Klampatsa from the Insitute of Cancer Research, and panellists included John Anderson from University College London, Michael Hudecek from University of Applied Sciences Wuerzburg-Schweinfurt, as well as Sebastian Kobold from Klinikum de Universität München.

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Can artificial intelligence help craft new medicines?

Drug Discovery World

Here, new bioassay technologies helped testing, but more definite answers were required. Expression patterns, proteomic profiles, bioassay results, and structures could now be captured en masse in normal and disease conditions. Thus, there was a dire need for new and effective drug targets.

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Accelerating NDA filing through faster carcinogenicity assessment

Drug Discovery World

While the discovery phase – which includes target discovery, target validation, lead compound identification, and lead compound optimisation – averages several years and $200 million, the majority of the research, time, and financial spend takes place downstream in drug development. In practice, this was typically conducted in rats and mice.