Roots Analysis

JANUARY 28, 2024

Pharmaceutical Research: Big data analytics can be applied in various areas of pharmaceutical research, including drug discovery and development, precision medicine , clinical trial optimization, pharmacovigilance and drug safety, supply chain optimization, and real-time monitoring and surveillance.

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Big Data Medicine Marketing Clinical Trials 40

Pharmaceutical Technology

AUGUST 30, 2022

Reduced solubility and low bioavailability affect a huge number of solid drug products, especially tablet formulations on the market. All the clinical and other development expenses will be handled by Insud. The firms are currently working on a second product candidate and plan to develop more products under the partnership.

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Drug Discovery World

APRIL 8, 2024

Dr Haushabhau Shivaji Pagire, first author and senior researcher at the Medicinal Chemistry Laboratory at GIST, said: “Our meticulous analyses have revealed a significant reduction in inflammatory and fibrosis markers, attesting to the potent anti-inflammatory and fibrotic effect of the compound.

Drugs 52

Drugs Bioavailability Clinical Trials Clinical Trials 52

The Pharma Data

OCTOBER 15, 2020

a leading biotechnology company developing small molecule therapeutics based on its proprietary uSMITE platform of targeted protein degradation technology, today announced that the company’s internal program to develop selective degraders that target key proteins within the TRK family has been published by the Journal of Medicinal Chemistry.

Protein 52

Protein Medicine Bioavailability Development 52

Drug Discovery World

OCTOBER 12, 2022

The FBDD technology is based on identifying these small chemical fragments which bind to the biological target, and which are then optimised into lead-like molecules (less than 400 g/mol) and finally into bioavailable drugs. Andreas Schoop, PhD, Head of Medicinal Chemistry, WuXi AppTec HitS & Moran Jerabek-Willemsen, PhD,?Head

Bioavailability 52

Bioavailability Drugs Medicine 52

Cloudbyz

MARCH 5, 2024

In the intricate dance of drug discovery and development, two protagonists emerge as the cornerstones of modern medicine: biologics and small molecules. Oral Bioavailability: Developing small molecules that are effectively absorbed when administered orally, while also being stable in the digestive system, can be complex.

Development 77

Development Drugs Manufacturing Immune Response 77

Drug Discovery World

OCTOBER 5, 2022

The FBDD technology is based on identifying these small chemical fragments which bind to the biological target, and which are then optimised into lead-like molecules (less than 400 g/mol) and finally into bioavailable drugs. Andreas Schoop, PhD, Head of Medicinal Chemistry, WuXi AppTec HitS & Moran Jerabek-Willemsen, PhD,?Head

Drugs 52

Drugs Bioavailability Medicine 52

Drug Discovery World

SEPTEMBER 28, 2022

The FBDD technology is based on identifying these small chemical fragments which bind to the biological target, and which are then optimised into lead-like molecules (less than 400 g/mol) and finally into bioavailable drugs. Andreas Schoop, PhD, Head of Medicinal Chemistry, WuXi AppTec HitS & Moran Jerabek-Willemsen, PhD,?Head

Drugs 52

Drugs Bioavailability Medicine 52

Drug Discovery World

SEPTEMBER 21, 2022

The FBDD technology is based on identifying these small chemical fragments which bind to the biological target, and which are then optimised into lead-like molecules (less than 400 g/mol) and finally into bioavailable drugs. Andreas Schoop, PhD, Head of Medicinal Chemistry, WuXi AppTec HitS & Moran Jerabek-Willemsen, PhD,?Head

Drugs 52

Drugs Bioavailability Medicine 52

Drug Discovery World

SEPTEMBER 15, 2022

The FBDD technology is based on identifying these small chemical fragments which bind to the biological target, and which are then optimised into lead-like molecules (less than 400 g/mol) and finally into bioavailable drugs. Andreas Schoop, PhD, Head of Medicinal Chemistry, WuXi AppTec HitS & Moran Jerabek-Willemsen, PhD,?Head

Drugs 52

Drugs Bioavailability Medicine 52

pharmaphorum

NOVEMBER 9, 2022

for the purpose of advancing disease-modifying oral medicines for debilitating chronic neurodegenerative disorders, by enabling investigational new drugs (IND) studies. A £16 million Series A financing – led by Omega Funds – has been announced by the innovative neuroscience company NRG Therapeutics Ltd.,

In-Vitro 52

In-Vitro Bioavailability Medicine Clinical Trials 52

The Pharma Data

DECEMBER 29, 2020

Cybin is developing technologies and delivery systems, aiming to improve bioavailability, to potentially achieve the desired medicinal effects of psychedelics at low dosage levels. Cybin is a life sciences company advancing psychedelic pharmaceutical treatments for various psychiatric and neurological conditions.

Life Science 52

Life Science Bioavailability Clinical Trials Clinical Trials 52

XTalks

FEBRUARY 3, 2023

Unlike fulvestrant, elacestrant is not only orally bioavailable, but it has also demonstrated longer steady-states and works as a better combination partner with inhibitor agents like CDK4/6. This approval follows the promising results of the Phase III EMERALD global clinical trial published in the Journal of Clinical Oncology.

Clinical Trials 97

Clinical Trials Clinical Trials FDA Approval Trials 97

The Pharma Data

JANUARY 5, 2021

“The ability to specifically target the 3D structure of RNA opens up an array of new possibilities in medicine, and Ribometrix is building the capabilities to deliver on that promise,” said Michael Solomon, chief executive officer of Ribometrix.

RNA 52

RNA Protein Bioavailability DNA 52

Roots Analysis

OCTOBER 2, 2023

Additionally, it increases the bioavailability and solubility of the attached molecule. In fact, in the last twenty years, the United States Food and Drug Administration (USFDA) and the European Medicines Agency (EMA) have authorized the market approval of around 80 nanomedicines.

Drug Delivery 40

Drug Delivery Drugs Bioavailability Marketing 40

pharmaphorum

MAY 5, 2021

Pfizer expects revenues from its BioNTech-partnered COVID-19 vaccine to reach an eye-watering $26 billion this year, catapulting it to the top of the world’s biggest-selling medicines. . Feature image copyright BioNTech SE 2020, all rights reserved. The post Pfizer says COVID-19 jab could rake in $26bn this year appeared first on.

Vaccination 105

Vaccination Vaccine Sales Bioavailability 105

XTalks

APRIL 11, 2023

By avoiding the stomach entirely, there is increased bioavailability and more sustained relief from symptoms. Ambroxol is a cough medicine in the mucolytics family (thins and removes mucus from airways). ND0612 is currently in Phase III of clinical development and is supported by four years of safety data.

Bioavailability 98

Bioavailability Genetics Nurses Development 98

Camargo

JULY 8, 2021

Researchers at the Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have observed that MAOIs might help the immune system attack cancer. Although still available as generics, for the most part they have been replaced by newer drugs with fewer side effects.

Development 130

Development Bioequivalency Gene Expression Drugs 130

Drug Discovery World

JULY 25, 2023

PIPs are mandatory for applicants seeking marketing authorisation for new medicines in the EU. The voluntary pilot scheme will start with eight sPIPs and will target medicines where elements of the PIP cannot be defined. They are required for orphan drugs but not for biosimilars.

Development 52

Development Drugs Medicine Production 52

The Pharma Data

MARCH 8, 2021

Molnupiravir (EIDD-2801/MK-4482) is an investigational, orally-bioavailable form of a potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. About Molnupiravir.

Trials 69

Trials In-Vivo Genotoxicity RNA 69

The Pharma Data

AUGUST 16, 2021

Lebrikizumab is a novel monoclonal antibody (mAb) that binds soluble IL-13 with high affinity, has high bioavailability, a long half-life and blocks IL-13 signaling. Fast Track designation is granted for a medicine that is intended to treat a serious condition and data demonstrate the potential to address an unmet medical need. .

Dermatology 40

Dermatology Trials Bioavailability Medicine 40

The Pharma Data

NOVEMBER 26, 2020

This novel nanoparticle formation technology provides hope for improving the possibilities and probabilities of developing better medicines for patients and it expands Nanoform’s reach into the growing biological market. Nanoform is an innovative nanoparticle medicine enabling company. HELSINKI , Nov. Finnish time.

Containment 52

Containment Medicine Bioavailability Clinical Trials 52

The Pharma Data

OCTOBER 9, 2021

“The treatment of CMV in patients who have undergone a solid organ or stem cell transplant is complicated, especially in patients who have failed standard treatment and who may be at risk for side effects from currently available medications,” said Dr. Emily Blumberg, Director, Transplant Infectious Diseases, Penn Medicine.

Drugs 52

Drugs Genotype Bioavailability Medicine 52

Roots Analysis

SEPTEMBER 1, 2023

By using real-world evidence , researchers can gain clinically useful insights that can help improve the quality of care delivery in precision medicine. As the field continues to advance, it is expected to have a profound impact on the future of medicine.

Drug Delivery 52

Drug Delivery Marketing Drug Delivery Systems Drugs 52

The Pharma Data

JANUARY 3, 2021

4, 2021 /PRNewswire/ — Nanoform Finland Plc (“Nanoform”), an innovative nanoparticle medicine enabling company, today announced a new near-term business target. Nanoform is an innovative nanoparticle medicine enabling company. HELSINKI , Jan. Finnish time. About Nanoform.

Containment 52

Containment Bioavailability Clinical Trials Clinical Trials 52

The Pharma Data

NOVEMBER 22, 2020

Founded in 2007, Alzprotect is a French Lille-based company created by Dr. André Delacourte, one of the pioneers of research on Alzheimer’s disease, and Dr. Patricia Melnyk, expert in medicinal chemistry, in collaboration with University of Lille and Inserm. About XERYS.

Drugs 40

Drugs Protein Bioavailability Development 40

Delveinsight

FEBRUARY 16, 2021

The data was presented at the virtual 2021 Genitourinary Cancers Symposium (ASCO GU) and also published in the New England Journal of Medicine. Maribavir is an orally bioavailable anti-CMV compound. The combo treatment also met key secondary endpoints of overall survival (OS) and objective response rate (ORR).

Marketing 52

Marketing Protein Bioavailability Drugs 52

The Pharma Data

DECEMBER 8, 2020

Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced the pricing of an underwritten public offering of 8,110,000 shares of its common stock at a price to the public of $37.00 SAN DIEGO, Dec. About Kura Oncology.

Bioavailability 52

Bioavailability Containment Sales Medicine 52

The Pharma Data

DECEMBER 1, 2020

–( BUSINESS WIRE )– Genesis Therapeutics , a company pioneering AI technologies to create medicines for patients with severe and unmet medical needs, has completed its $52M Series A financing round. 2, 2020 11:00 UTC. BURLINGAME, Calif.–( Rock Springs Capital led the round. Feinberg, Ph.D., Genesis’ CEO and co-founder. “We

Development 40

Development Drugs Engineer FDA Approval 40

The Pharma Data

DECEMBER 9, 2020

Li is a prominent neuroscientist and former professor at Johns Hopkins Medicine. Artificial intelligence holds immense promise to catalyze the development of the next generation of highly selective, orally bioavailable molecules, with reduced side effects, for the most impactful drug targets,” Feinberg said at the time of the launch.

Marketing 52

Marketing In-Vivo Protein In-Vitro 52

The Pharma Data

NOVEMBER 19, 2020

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. Several compounds are being further optimized for preclinical studies. Details can be found at this link.

Development 40

Development Bioavailability Production Drugs 40

The Pharma Data

DECEMBER 3, 2020

Food and Drug Administration and European Medicines Agency as we work to bring maribavir to patients.”. Maribavir, an orally bioavailable anti-CMV compound, is the only antiviral agent presently in Phase 3 development for the treatment of post-transplant patients with CMV in SOT or HSCT. About Maribavir.

Drugs 52

Drugs Medicine Trials Containment 52

The Pharma Data

MARCH 11, 2021

Last May, Lilly’s first-in-class oral precision medicine, Retevmo received Accelerated Approval from the U.S. Presentation Title: Preclinical characterization of LY3484356, a novel, potent and orally bioavailable selective estrogen receptor degrader (SERD). Portfolio Highlights. Abstract Number: 1236. Retevmo is an U.S.

Research 52

Research Clinical Trials Clinical Trials Trials 52

Delveinsight

JULY 30, 2020

A novel, brain penetrant, orally bioavailable and selective PPAR? Magenta Therapeutics , a clinical-stage biotechnology company is evaluating its one-time cell therapy, MGTA-456 for the treatment of multiple inherited metabolic disorders, which has received Regenerative Medicine Advance Therapy (RMAT) designation from the US FDA.

Hormones 52

Hormones Marketing Gene Trials 52

Pharmaceutical Technology

NOVEMBER 24, 2022

The number of commercially available 14 C-labeled starting materials is limited, and unlike the medicinal chemistry or process chemistry routes, we are restricted to a few very simple building blocks. This has proved to be an extremely effective option for molecules where an understanding of absolute bioavailability is required.

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Bioavailability Manufacturing Drugs Production 130

Drug Discovery World

DECEMBER 7, 2022

Different polymorphs of the same active pharmaceutical ingredient (API) can have profound effects on solubility, permeability, and bioavailability, as well as manufacturability. Different crystalline structures mean that these polymorphs will very likely have different properties such as bioavailability and solubility.

Bioavailability 52

Bioavailability Manufacturing Production Development 52

Drug Discovery World

AUGUST 9, 2023

The discovery of a second, more stable polymorphic form of Ritonavir (form II) within the originally formulated drug product (form I) resulted in a reduction in bioavailability that led to the product’s withdrawal.

Research 52

Research Bioavailability Scientist Drugs 52