article thumbnail

FDA expands organ-on-a-chip research collaboration

Drug Discovery World

The system will initially be investigated for improving the preclinical estimation of human drug bioavailability compared to standard animal models. . Dr Emily Richardson, Lead Scientist at CN Bio, said: “We are extremely pleased with the FDA’s decision to deepen our research collaboration into the multi-organ space.

article thumbnail

Roquette opens pharmaceutical innovation facility in Pennsylvania, US

Pharmaceutical Technology

In the first phase of its training workshops, the Pharmaceutical Innovation Center plans to develop a range of excipients [inactive substances that serve as the vehicle or medium for a drug or other active substance] for controlled release dosage forms, improving their bioavailability, along with formulating orally dispersible and chewable tablets.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Potent drug candidate could transform liver disease treatment

Drug Discovery World

Scientists from Gwangju Institute of Science and Technology in Korea have discovered compound 11c, a potentially ground-breaking oral treatment for metabolic dysfunction-associated steatohepatitis. Their research signals a transformative leap in liver disease management, addressing both inflammation and fibrosis.

Drugs 52
article thumbnail

How PK Modeling Can Inform Sample Size Estimation and Dose Selection for Your Product

Camargo

The results of the population analysis reveal the average relative bioavailability of the test to reference. The comparison of relative bioavailability based on simulated data then indicates if BE can be achieved. Pharmacokinetics Scientist. Co-Authors: Galina Bernstein, PhD. Senior Director, Clinical Pharmacology. Pop-Pharm.

article thumbnail

PROTACs show promise for cancer treatment

Pharmaceutical Technology

Syngene has more than seven years of experience with 450+ scientists working in targeted protein modulator (degraders and stabilizers) class, both in chemistry and biology under different collaborative projects. Syngene’s PROTAC capabilities put it at the forefront of developing novel protein degraders across a range of diseases.

Protein 130
article thumbnail

Welsh startup Antiverse raises $2m for antibody discovery toolkit

pharmaphorum

Antiverse – which was co-founded in 2017 by engineers Murat Tunaboylu and Ben Holland – says it will use the cash injection to build a new laboratory in Cardiff and expand its technical team through recruitment of specialist machine learning engineers, laboratory scientists and structural biologists.

article thumbnail

CycPeptMPDB: A database aimed at promoting drug design using cyclic peptides

The Pharma Data

This is a fine balance to achieve – if the compounds are too large, they may not pass through the cell membrane, and their bioavailability would be affected; if they are too small, they would not retain high specificity to the target protein (or proteins).

Drugs 40