Scienmag

JUNE 11, 2021

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells PHILADELPHIA – Cells contain machinery that duplicates DNA into a new set that goes into a newly formed cell.

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DNA RNA Containment Research 58

Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

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DNA Regulation Genome Genomics 62

Scienmag

OCTOBER 13, 2020

Researchers find that simple DNA-peptide interactions create a surprising diversity of compartmentalised higher-ordered phase behaviours, suggesting that these polymers’ primordial interactions helped create modern complex biological structures. For example, each human cell contains about 2 meters worth of DNA, but this is […].

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DNA Containment Protein Research 52

XTalks

APRIL 29, 2021

However, the variant viral genomes will still persist in the latent reservoir as provirus and can be detected with proviral DNA testing. In contrast to HIV RNA, HIV proviral DNA remains present in a patient’s cells even during virological suppression. Proviral DNA Genotyping. HIV Drug Resistance Testing.

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DNA Drugs RNA Genotype 98

Scienmag

OCTOBER 22, 2020

When animals eat, prey DNA travels all the way through animal digestive tracts and comes out again. Poop contains very precise information about the prey […]. For scientists, digging into feces provides insights into animal diets and is particularly useful for understanding nocturnal or rare species.

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DNA Containment Scientist Bioinformatics 54

pharmaphorum

SEPTEMBER 14, 2021

Startup Rome Therapeutics has raised $77 million in second-round financing to help mine sequences of DNA – which were dismissed for years as ‘junk’ – for hidden treasure. Much of this repeatome is thought to derive from viruses that embedded in our DNA millions of years ago.

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DNA Immune Response Genome Genomics 52

Scienmag

JUNE 29, 2022

The sub-basement Collections Resource Center houses millions of biological specimens for scientists around the world to use in their research, including countless bottles and jars containing pickled fish, lizards, and snakes, arranged like a library. Many of these specimens are decades or even centuries old, […].

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DNA Containment Scientist Research 62

Scienmag

SEPTEMBER 14, 2021

The term ‘DNA’ immediately calls to mind the double-stranded helix that contains all our genetic information. But the individual units of its two strands are pairs of molecules bonded with each other in a selective, complementary fashion.

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DNA Gene Containment Genetics 40

Scienmag

APRIL 23, 2021

Credit: Gemma Lofthouse An international team of researchers led by the University of Bergen has uncovered how organisms from crops to corals may avoid deadly DNA damage during evolution. Our cells, and those of animals, plants and fungi, contain compartments that produce chemical fuel.

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DNA Containment Research Genetics 89

Scienmag

SEPTEMBER 22, 2021

A new sensor can detect not only whether a virus is present, but whether it’s infectious – an important distinction for containing viral spread. CHAMPAIGN, Ill. — Credit: Image courtesy of Ana Peinetti CHAMPAIGN, Ill. — A new sensor can detect not only whether a virus is present, but whether it’s infectious – an important […].

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Medical Xpress

FEBRUARY 13, 2023

The gut microbiota contains trillions of bacteria that can promote health or cause disease under different conditions. The collective DNA sequences that make up the bacteria flora, is called the microbiome.

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Bacteria DNA Containment Research 74

Pharmaceutical Technology

MARCH 28, 2023

In 2021, the FDA gave Jemperli an accelerated approval for the treatment of adult patients with mismatch repair deficient (dMMR) recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing regimen. These cells are prone to DNA mutations that can often lead to cancer.

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DNA Clinical Trials Clinical Trials Trials 130

Scienmag

MAY 11, 2022

NEW YORK CITY, May 11, 2022 – Credit: Memorial Sloan Kettering Cancer Center NEW YORK CITY, May 11, 2022 – Many cancers contain similar genetic “hotspots” — areas of DNA that are likely to be mutated. For example, more than 50% of cancers contain a mutation in a gene called TP53, often within a narrow DNA […].

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Genetics DNA Containment Gene 62

Scienmag

JUNE 13, 2022

The legible sections contained the code for making cell proteins; the other regions, representing about 90% of the entire genome, were dismissed as “junk DNA,” […].

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Genome Genomics DNA Containment 77

Scienmag

JULY 14, 2021

Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles Credit: Mindy Takamiya/Kyoto University iCeMS Cancer cell death is triggered within three days when X-rays are shone onto tumor tissue containing iodine-carrying nanoparticles. The findings, by scientists at Kyoto […].

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DNA Containment Scientist Research 97

Scienmag

NOVEMBER 15, 2021

Cell biologists track this process by observing chromosomes—structures made of DNA that contain the genetic material of an organism. Cell division is an important process that underlies biological growth and repair. However, their analysis is still […].

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DNA Containment Genetics Research 83

Scienmag

OCTOBER 27, 2021

Carbon is the cornerstone of most biologically produced organic compounds such as proteins, carbohydrates, fats and DNA. All of these compounds contain, in addition to carbon, many other […]. Through the course of evolution, living organisms have learned to form and process large numbers of different carbon compounds.

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DNA Containment Protein 81

Scienmag

APRIL 8, 2021

This full assembly may contain clues to ape and human divergence; certain immune, brain and heart disorders; and other biomedical questions Credit: Kendra Hoekzema The full assembly of human chromosome 8 is reported this week in Nature.

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Gene DNA Containment Genetics 90

Scienmag

SEPTEMBER 17, 2020

They have to precisely divide to form new specialized cells, which are destined to different fates even though they contain identical DNA. Credit: Andrew Muroyama The stem cells tasked with creating and maintaining biological tissues have a difficult job.

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Scienmag

JULY 3, 2022

Researchers who treated a group of post-surgery bladder cancer patients with the immunotherapy drug atezolizumab have found that patients whose blood contained circulating tumour DNA (ctDNA), responded very well to the treatment. The study is presented today at the European Association of Urology annual congress (EAU22), in Amsterdam.

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DNA Containment Research Drugs 67

STAT News

OCTOBER 12, 2022

From the outside, this would appear to be a pretty run-of-the-mill neuroscience experiment, except for the fact that the neurons directing the rat to its thirst-quenching reward didn’t contain any rat DNA.

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DNA Containment Scientist Medicine 144

Scienmag

OCTOBER 6, 2021

In the cell’s power plants, known as mitochondria, the energy contained in our food is converted into the molecule ATP. It serves as a kind of fuel that drives most cellular processes – from muscle contraction to the assembly of our DNA. In order to fulfill their many tasks, cells need energy.

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DNA Containment Medicine 52

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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Scienmag

OCTOBER 7, 2020

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

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RNA DNA Containment Bioinformatics 69

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. The vaccine also contains other inactive ingredients such as cholesterol.

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Vaccination Vaccine Containment Immune Response 130

XTalks

NOVEMBER 28, 2023

Indicated for the treatment of trichomoniasis in adults, amebiasis in both adults and pediatric patients and anaerobic bacterial infections in adults, Likmez is available as an oral suspension, with each 5 mL containing 500 mg of metronidazole.

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Drug Discovery World

MAY 5, 2023

In contrast to DNA-based reprogramming and gene editing, the mRNA-based approach does not expose cells to expensive and potentially harmful viruses or DNA vectors. Eterna plans to use Exacis’ platform to develop engineered cell therapies containing genomic edits designed to enhance their performance.

Gene Editing 52

Gene Editing Engineer DNA Life Science 52

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

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Drug Discovery World

JANUARY 26, 2023

The researchers believe smaller cells could be more vulnerable to DNA-damaging agents like chemotherapy combined with targeted drugs, while larger cancer cells might respond better to immunotherapy. In contrast, the larger NRAS-mutant cancer cells contained damage to their DNA instead of repairing it, accumulating mutations and enlarging.

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DNA Protein Genetics Research 52

BioTech 365

JULY 15, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Researchers use laser ‘tweezers’ to study structure and dynamics of chromatin.Each one of the cells in our body contains DNA, which provides the instructions required for our … Continue reading →

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FDA Law Blog

DECEMBER 8, 2022

Most notably, the draft guidance clarifies that the following food products are subject to the allergen labeling requirements: Bulk containers (e.g., Most notably, the draft guidance clarifies that the following food products are subject to the allergen labeling requirements: Bulk containers (e.g., airlines).

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Genetic Engineering Containment Cosmetics Protein 59

Drug Discovery World

OCTOBER 19, 2022

Yapan Bio has expanded its capabilities with a new process development facility at Genome Valley, Hyderabad, India, which has enhanced its ability to support end-to-end development and manufacturing of RNA, DNA and gene therapy products starting from plasmids. .

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Development Gene Therapy RNA DNA 52

Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses.

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RNA In-Vivo In-Vitro DNA 64

Scienmag

OCTOBER 4, 2020

DNA, which carries genetic information in cells, contain biological instructions. CHICAGO – Researchers have identified genetic mutations that appear to protect women from severe bleeding after childbirth, a leading cause of maternal death. A genetic mutation, which is a permanent […].

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Genetics Research DNA Containment 40

Drug Discovery World

DECEMBER 20, 2023

BCLM genetically distinct from primary breast tumour For this study, researchers at the Breast Cancer Now Toby Robins Research Centre at the ICR analysed liquid biopsies, which contain circulating tumour DNA (ctDNA).

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Drugs Genetics Research DNA 105

Drug Discovery World

DECEMBER 14, 2023

The Bio X AI policy recommendations address the need for oversight of biodesign AI tools, biosecurity screening of synthetic DNA and guidance on biosecurity practices for automated laboratories.

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Scientist DNA Life Science Development 52

The Pharma Data

SEPTEMBER 11, 2021

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

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Antibody DNA Containment Manufacturing 52