Mon.Jan 25, 2021

Merck stops coronavirus vaccine development in surprise setback

Bio Pharma Dive

The drugmaker, one of the largest vaccine developers globally, won't move forward with either of two candidates it's been testing after disappointing data in early trials

The complicated ROI measurement for pharma

World of DTC Marketing

SUMMARY: The LinkedIn team had a unique take on measuring ROI. “77% of marketers measure ROI within the first month of their campaign, knowingly trying to “prove ROI in a shorter amount of time than their typical sales cycle.,

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FDA approves first-of-its-kind lupus drug

Bio Pharma Dive

Lupkynis, the first oral drug approved for lupus nephritis, comes with a high list price. Its developer, Aurinia Pharmaceuticals, expects average net revenue of roughly $65,000 per patient per year

In ED patients with chest and abdominal pain, care delivered by physicians and APPs is similar

Scienmag

Credit: KIRSTY CHALLEN, B.SC., MBCHB, MRES, PH.D., LANCASHIRE TEACHING HOSPITALS, UNITED KINGDOM.

AstraZeneca, with new data, claims its leukemia drug is safer than Imbruvica

Bio Pharma Dive

A head-to-head study showed Calquence and Imbruvica benefited patients similarly, but AstraZeneca's drug had fewer heart-related side effects

Drugs 188

Over-the-Counter Nasal Spray Could Be Effective Against COVID-19

BioSpace

An in vitro study conducted by scientists from Northwestern University and Utah State University concluded that components found within the Xlear nasal spray, particularly grapefruit seed extract and xylitol, were successful in statistically reducing the amount of SARS-CoV-2 in a patient

Moderna to study vaccine booster aimed at coronavirus variant

Bio Pharma Dive

Laboratory tests indicated the biotech's shot would still protect against virus variants detected in the U.K. and South Africa, although the latter appeared to result in a weaker immune response

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COVID-19 study builds at pandemic speed

Bio Pharma Dive

How to accelerate time-to-market, gain greater control of study data and execution, and optimize the entire trial lifecycle

Trials 144

In Israel, Infections Drop Sharply After One Shot of Vaccine

NY Times

Initial studies show a significant drop in infections and hospitalizations after just one dose, and very few cases after two. Experts caution that the results are preliminary.

Spotlight on EU executive’s handling of vaccine supply contracts

BioPharma Reporter

The European Ombudsman is investigating the secrecy with which the EU executive is handling COVID-19 vaccine supply contracts. Markets & Regulations

Clinical research in 2021: A new era of collaboration and innovation

Pharma Phorum

The clinical research community has been disrupted in a number of ways due to COVID-19 and sparked a spirit of collaboration and innovation. Worldwide Clinical Trial’s Aman Khera gives five predictions of how clinical research could change in 2021.

UK doctors ask for ‘urgent review’ of COVID-19 vaccine second dose delay

BioPharma Reporter

The British Medical Association (BMA), the trade union and professional body for doctors in the UK, is calling for the delay between Pfizer/BioNTech COVID-19 vaccine doses to be reduced from 12 weeks to six weeks. Markets & Regulations

Domino effects and synchrony in seizure initiation

Scienmag

Credit: Figure courtesy of Jennifer Creaser and Sprice Machines. Epilepsy, a neurological disease that causes recurring seizures with a wide array of effects, impacts approximately 50 million people across the world.

Moderna developing COVID-19 vaccine booster shot against South Africa variant

BioPharma Reporter

An in vitro study shows Moderna's existing mRNA COVID-19 vaccine provides protection against strains that have emerged from South Africa and the UK.

Newly discovered subset of brain cells fight inflammation with instructions from the gut

Scienmag

Findings on a novel anti-inflammatory pathway may guide researchers toward innovative multiple sclerosis or brain tumor treatments Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized. Researchers have long assumed that astrocytes’ primary function is to provide nutrients and support for the brain’s more closely […]. Medicine & Health Medicine/Health Neurobiology

COVID-19 Variants: More Infectious, More Lethal, but Vaccines Could Still Be Effective

BioSpace

British scientists suggested last week that the U.K. variant may be approximately 30% more lethal than the most common strain that came out of China. But they’re not completely sure of this yet

Merck exits COVID-19 vaccine development, cites disappointing data

BioPharma Reporter

Merck is shutting down the programs linked to its two COVID-19 vaccine candidates following early trial data indicating that they failed to generate immune responses comparable to a natural infection or existing vaccines. Bio Developments

Regeneron’s COVID-19 Antibody Cocktail Works as 'Passive Vaccine'

BioSpace

Regeneron announced positive initial data from its ongoing Phase III trial of its antibody cocktail, REGEN-COV, as a passive vaccine to prevent COVID-19 in people at high risk of infection from household exposure

PMN WEBINAR: Video, Voice, and Virtual: Applying New Digital Technology to Enhance Customer Experience

Pharma Marketing Network

Pharma-Marketing is owned and operated by eHealthcare Solutions. The post PMN WEBINAR: Video, Voice, and Virtual: Applying New Digital Technology to Enhance Customer Experience appeared first on Pharma Marketing Network. Articles

How did Florida fail to respond to a coral disease epizootic and what’s to follow?

Scienmag

Credit: William Precht By 2020, massive losses of large populations of corals have been observed throughout Florida and into the greater Caribbean basin.

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FDA approves injectable treatment for HIV patients

Outsourcing Pharma

The agency has given the thumbs up to ViiVâs once-a-month Cabenuva, the first FDA-approved injectable, complete regimen for adults diagnosed with HIV. Markets & Regulations

Breakthrough design at UBCO vastly improves mechanical heart valve

Scienmag

A twist on the decade’s-old design improves blood flow, prevents clots Credit: UBCO New research coming out of UBC’s Okanagan campus may take the current ‘gold standard’ for heart valves to a new level of reliability.

eCOA tech helps trials tackle COVID-19 obstacles: IQVIA

Outsourcing Pharma

Two leaders from the clinical technology solutions company discuss how digital tools like eCOAs have been invaluable in facing pandemic-related challenges. Clinical Development

Highly specific synaptic plasticity in addiction

Scienmag

Cues trigger enzyme activity outside specific cell types Credit: Elsevier Philadelphia, January 26, 2021 – Addiction, or substance use disorder (SUD), is a complex neurological condition that includes drug-seeking behavior among other cognitive, emotional and behavioral features.

Drugs 56

GSK suffers another R&D setback, axing ulcerative colitis drug trial

Pharma Phorum

GlaxoSmithKline has suffered another research setback after it axed a phase 2 trial of an anti-LAG3 drug in patients with ulcerative colitis, following a major disappointment with a key lung cancer drug last week.

Impact of patient-reported symptom information on lumbar spine MRI Interpretation

Scienmag

Veralox Therapeutics Announces FDA Orphan Drug Designation for VLX-1005

The Pharma Data

26, 2021 13:00 UTC. FREDERICK, Md.–( –( BUSINESS WIRE )– Veralox Therapeutics, a biotechnology company developing first-in-class small molecule therapeutics that treat the underlying pathologies of diseases with significant unmet medical needs, today announced that the U.S.

Inequality in medieval Cambridge was ‘recorded on the bones’ of its residents

Scienmag

Credit: Nick Saffell Social inequality was “recorded on the bones” of Cambridge’s medieval residents, according to a new study of hundreds of human remains excavated from three very different burial sites within the historic city centre.

CSL: Driven by Its Promise to Deliver for COVID-19 Patients

The Pharma Data

Vicky Pirzas, CSL Behring’s Vice President of Recombinant Product Development (left) and Deirdre BeVard, CSL Behring’s Senior Vice President for Research and Development Strategic Operations (right).

Governments need to set clear rules for vaccinating health care workers against COVID-19

Scienmag

Marinus Enrolls First Patient in Pivotal Phase 3 Clinical Trial of IV Ganaxolone in Refractory Status Epilepticus

The Pharma Data

26, 2021 12:01 UTC. Marinus and Ceribell, Inc. agree to place handheld Ceribell Rapid Response EEG systems in hospitals in connection with its Phase 3 RSE clinical trial. RADNOR, Pa.–( –( BUSINESS WIRE )– Marinus Pharmaceuticals, Inc.

How fast could SARS-CoV-2 be detected?

Scienmag

Credit: @Science China Press In the past 20 years, humans have suffered several serious epidemics from emerging viruses, such as SARS, swine flu, Ebola, MERS and (most recently) SARS-CoV-2.

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Midatech Pharma PLC Announces Business Update

The Pharma Data

ABINGDON, OXFORDSHIRE / ACCESSWIRE / January 26, 2021 / Midatech Pharma PLC (AIM: MTPH.L; Nasdaq: MTP), an R&D biotechnology company focused on improving the bio-delivery and biodistribution of medicines, announces a number of updates: 1. Q-Sphera Pipeline.

New book on Influenza: The Cutting Edge from CSHLPress

Scienmag

Credit: Image courtesy of Michiko Ujie and Masaki Imai, Institute of Medical Science, University of Tokyo Cold Spring Harbor, NY. Cold Spring Harbor Laboratory Press (CSHLP) announced the publication of Influenza: The Cutting Edge, available on its website in ebook and hardcover formats.

BridgeBio Pharma, Inc. Prices Upsized Offering of $650 Million Convertible Senior Notes

The Pharma Data

PALO ALTO, Calif., 25, 2021 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc.

Sales 52

First observation of the early link between proteins linked to Alzheimer’s disease

Scienmag

These results will help researchers to identify at an early stage the people most at risk of developing the disease, well before the first cognitive symptoms appear Credit: ©ULiège/CRC In Vivo Imaging Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the […].

Ambulero Raises Up To $5.5 Million from Orphinic ScientificMiami Cell and Gene Therapy Company Opens European Subsidiary To Advance Gene Therapy For Rare Vascular Disease

The Pharma Data

MIAMI, Jan. 25, 2021 (GLOBE NEWSWIRE) — Ambulero, Inc. , a biotechnology company developing cell and gene therapy treatments for patients suffering from vascular disease, today announced that it raised up to $5.5M in funding from Orphinic Scientific (“Orphinic”).