XTalks

MAY 12, 2021

In this episode, Ayesha discusses a new tool that uses CRISPR to modulate gene expression without editing DNA sequences. Dubbed “CRISPRoff,” the technology targets the epigenome to silence genes involved in diseases, with applications in cancer, AML and other conditions with a heritable component.

Life Science 52

Life Science Gene Expression Gene DNA 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. Related: 2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences. We can do this for multiple genes at the same time without any DNA damage, and in a way that can be reversed.

DNA 98

DNA Gene Gene Silencing Genome 98

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. Related: 2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences. We can do this for multiple genes at the same time without any DNA damage, and in a way that can be reversed.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

JULY 18, 2023

While type II (Cas9) is mainly used for gene-editing applications, CRISPR detecting tools primarily rely on type V (Cas12) and type VI (Cas13) collateral activity. It also enables the downregulation of gene expression by directly knocking out the cytoplasmic mRNA transcripts.

DNA 98

DNA Genome Genomics RNA 98

XTalks

FEBRUARY 11, 2021

After several such Nobel Prize snubs for female scientists, 2020 saw the Nobel Prize in Chemistry go to a female scientist duo for the first time for their revolutionary discovery of the CRISPR-Cas9 gene editing system. As a Black female scientist, her legacy is one that will continue to inspire generations of Black women to come.

Genetics 119

Genetics DNA Genome Genomics 119

XTalks

SEPTEMBER 21, 2020

This difference could be mitigated when the scientists used a gene editing technique to either reduce KDM6A protein levels in the female-derived neurons, or increase KDM6A levels in neurons from males. Increasing KDM6A expression in male mice led them to be more resilient to the effects of amyloid beta plaques. KDM6A Variant.

Gene 89

Gene Protein Gene Expression Scientist 89

XTalks

DECEMBER 24, 2020

The pandemic propelled the life science and healthcare sectors onto center stage, and they rose to the occasion against the most unprecedented health challenge in recent times. While COVID-19 has undoubtedly been the biggest story in the life science industry in 2020, it was a busy and positive year in many other areas.

Life Science 111

Life Science Vaccination Vaccine Gene 111