pharmaphorum

FEBRUARY 16, 2022

The scientists stress that this is not a feasible treatment for most people with HIV, as a stem cell transplant can be a dangerous medical procedure that is only used for people with life-threatening conditions. The second man from London has now been in HIV remission for more than 30 months. Dr. Anthony Fauci, who has led the U.S.

Gene Editing 69

Gene Editing Research Gene Genetics 69

Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

Drugs 52

Drugs Gene Editing Genome Genomics 52

pharmaphorum

OCTOBER 7, 2020

Drs Emmanuelle Charpentier and Jennifer Doudna have won this year’s Nobel Prize for chemistry in recognition of their work on the gene-editing technology CRISPR/Cas9. million) Nobel Prize award. “In The post CRISPR pioneers Doudna and Charpentier claim Nobel chemistry prize appeared first on.

Gene Editing 105

Gene Editing Bacteria DNA Gene 105

XTalks

JANUARY 26, 2024

Innovations in Cancer Therapy CRISPR/Cas9, a groundbreaking gene-editing technology, has demonstrated significant potential in oncology, offering new avenues for cancer treatment. CRISPR/Cas9 offers a pathway to potentially overcome this, by modifying genes that are responsible for drug resistance in cancer cells.

Research 118

Research Gene Editing Gene Genetics 118

Scienmag

AUGUST 18, 2020

In Nature Communications, Fred Hutch scientists demonstrate in a mouse model how gene therapy could cure an infection that afflicts billions of people Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

Gene Therapy 45

Gene Therapy Gene Gene Editing Scientist 45

pharmaphorum

NOVEMBER 1, 2022

Investigating the next generation of genetic medicine through RNA based therapies. RNA therapeutics is a rapidly expanding industry with increasingly growing potential for immunotherapy, personalised medicines, and treatment of genetic, infectious, and chronic diseases. Senior and expert scientists. Director, Genetic Medicine.

RNA 52

RNA Genetics Gene Editing In-Vitro 52

Drug Discovery World

OCTOBER 31, 2022

The last month has seen huge strides forward in our understanding of cancers, particularly in how they develop resistance to therapies and how we can ‘outsmart’ them using gene editing or different therapeutic pathways, but also how we can better target drugs to individuals and accurately predict treatment outcomes.

Drugs 52

Drugs Research Gene Editing Protein 52

Drug Discovery World

JULY 10, 2023

If there’s one thing I would take from the Summer 2023 issue of Drug Discovery World , it would be that the application of technologies and processes throughout the pharmaceutical industry are changing how scientists pursue the development of therapies. The new issue of DDW is available to view now.

Gene Therapy 52

Gene Therapy Gene Scientist Gene Editing 52

Drug Discovery World

JANUARY 12, 2023

Scientists use complex gene editing and disease modeling systems to gain insights on the potential of CRISPR. . Most gene editing studies are performed in traditional 2D culture systems that model a simplified version of the tissue and biology in question. Limitations of organoids.

Gene Editing 98

Gene Editing Gene Drugs In-Vivo 98

Drug Discovery World

NOVEMBER 7, 2022

Genomic healthcare data is critical to identify disease risk, ancestry, traits and response to medicines and aids in the development of new targeted therapies – precision medicines. The scientists said the results support the use of WGS as a standard diagnostic tool within routine clinical practice and the study 3. .

Genome 98

Genome Genomics Development Genetics 98

XTalks

FEBRUARY 8, 2024

This day, observed globally on February 11, underscores the critical role of gender equality in science, spotlighting the achievements of women pioneers in the field while also emphasizing the need to encourage and support the next generation of female scientists.

Life Science 105

Life Science Scientist Gene Editing Research 105

pharmaphorum

NOVEMBER 23, 2021

It can accommodate more than 2,200 research scientists, has 19,000 square metres of lab space, and boasts “the most advanced robotics, high-throughput screening and AI-driven technology,” according to AZ.

Gene Editing 106

Gene Editing Life Science Pharma Companies Clinical Trials 106

pharmaphorum

SEPTEMBER 29, 2020

Cell therapy research has been built on collaborations amongst scientists and entrepreneurs, providing early proof of concept for modalities thought to be too difficult to commercialise but with a strong potential for patient benefit”.

Research 132

Research Gene Editing Gene Development 132

Drug Discovery World

DECEMBER 12, 2022

The announcement followed the signing of deals to make new medicines available across the country. . According to the publication, “A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognise mutated proteins specific to a person’s tumours.

Drugs 52

Drugs Gene Editing Genome Genomics 52

Bioengineer

JULY 19, 2021

Researchers at the Wake Forest Organoid Research Center (WFORCE), a joint venture between the Wake Forest Institute for Regenerative Medicine (WFIRM), and the Wake Forest Comprehensive Cancer Center, were the first to create appendiceal cancer organoids to use as a predictive model for potential treatment options (published 2018).

Engineer 52

Engineer Medicine Clinical Trials Clinical Trials 52

XTalks

JULY 14, 2022

A downstream approach has traditionally been used by scientists to map networks, wherein a gene for a protein is removed one at a time and the impact on the immune cell’s function is observed. CRISPR-Cas9 gene editing was used to simultaneously perturb thousands of genes by targeting specific points of genetic code.

Gene 98

Gene Regulation Protein Gene Editing 98

The Pharma Data

SEPTEMBER 3, 2020

Current scientific techniques are not yet safe or effective enough to be used to create gene-edited babies, an international committee says. The world’s first gene-edited babies were born in China in November 2018. The scientist responsible was jailed, amid a fierce global backlash. What does the report say?

Gene Editing 52

Gene Editing Gene Genome Genomics 52

The Pharma Data

MARCH 7, 2022

Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports. “The beauty of this approach is we can safely upregulate specific genes to affect cell activity without permanently changing the genome and cause unintended mistakes,” Levy said. .

Protein 52

Protein Gene Genome Genomics 52

Delveinsight

FEBRUARY 25, 2021

Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s genetic medicines to more tissues in the body, widening the potential to approach more diseases. The gene-editing technologies, which have reached the clinic, CRISPR, zinc finger nucleases, and TALENs, make their edits by nicking DNA at the target site.

DNA 52

DNA In-Vivo Genetics Medicine 52

Delveinsight

AUGUST 27, 2020

The two drugs combined with radiation cleared the brain metastases in 75% of the animals, as reported in the journal Science Translational Medicine. Now, a research team that is led by scientists at Harvard University have used the CRISPR-Cas9 gene-editing technology to engineer human white fat so that it shows the properties of brown fat.

Vaccination 53

Vaccination Vaccine Research Trials 53

The Pharma Data

NOVEMBER 16, 2020

16, 2020 — Scientists are reporting early success with an experimental herpes vaccine that uses a genetically modified version of the virus. The gene edit prevents the virus from performing its normal evasive maneuver: hiding out in nervous system cells in order to elude the immune system. MONDAY, Nov.

Vaccination 52

Vaccination Vaccine Immune Response Genetics 52

STAT News

NOVEMBER 4, 2022

A man with muscular dystrophy who was first in line to receive an experimental gene editing therapy tailor made to treat the cause of his rare form of the disease has died. The treatment used a new version of CRISPR to turn on a backup copy of the dystrophin gene that mysteriously lies dormant in our muscles.

Gene Editing 105

Gene Editing Gene Gene Therapy Clinical Trials 105

Drug Discovery World

NOVEMBER 24, 2023

However, as we see every day, modern medicine has both incremental and major improvements, showing that the best innovations and most transformative outcomes can come from extreme pressures. But ultimately, for medicines to be rolled out worldwide, they need to work with not against the market.

Research 59

Research Life Science Gene Editing Vaccination 59

Drug Discovery World

SEPTEMBER 6, 2022

The cell and gene therapy industry has experienced exponential growth in the last three years and as funding for the field continues to break records there are no signs of a slowdown. With 2,261 ongoing clinical trials in regenerative medicine, the FDA expects to approve 1 between 10 and 20 new cell and gene therapies a year by 2025.

Gene Therapy 52

Gene Therapy Gene Manufacturing Clinical Trials 52

The Pharma Data

NOVEMBER 22, 2021

AstraZeneca will moment, in the presence of His Royal Highness The Prince of Wales, formally unveil The Discovery Centre ( Slice) in Cambridge, UK – a state-of-the- art exploration and development ( R&D) installation designed to the world’s loftiest environmental norms and accommodating over exploration scientists.

Gene Editing 52

Gene Editing Engineer Production Scientist 52

Advarra

NOVEMBER 29, 2022

The field of cell and gene therapies (CGT) is constantly evolving, and there has been significant progress in this area of research. However, despite the promise of these therapies, the regulations governing them lag the science, which in turn hinders the clinical translation of these novel medicines.

Gene Therapy 52

Gene Therapy Gene Production Clinical Trials 52

The Pharma Data

JANUARY 17, 2021

As we advance our gene therapy through clinical trials, this partnership signifies a critical milestone in the development pathway.” ” Aruvant is building a hybrid supply model that is led by the company’s cell and gene therapy scientists and leverages specialized external suppliers.

Manufacturing 52

Manufacturing Gene Therapy Trials Gene 52

Drug Discovery World

NOVEMBER 16, 2022

In April 2021, life sciences solutions provider Molecular Devices launched its Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process. . 2D vs 3D . 2D biology has been used by pharmaceutical researchers for decades. 2D vs 3D .

Drugs 97

Drugs In-Vivo In-Vitro Scientist 97

Drug Discovery World

APRIL 14, 2023

The American Association for Cancer Research (AACR) will honour the following cancer researchers, physician-scientists, advocates, and journalists during its annual meeting to be held April 14-19 at the Orange County Convention Center in Orlando, Florida.

Genetics 52

Genetics Research Medicine Clinical Research 52

Drug Discovery World

OCTOBER 16, 2023

Indeed, this is bolstered by top tier universities like Newcastle University, which specialises in structure-based approaches for drug discovery, developing innovative technologies that support the identification of new medicines, and is well-established in cancer drug discovery. Government investment of £1.3

Drugs 75

Drugs Life Science Gene Therapy Genome 75

Drug Discovery World

APRIL 3, 2023

As a business of scientists, we remain passionate about the exciting developments in the industry, from research to precision therapies, and insatiably curious about the new possibilities that can be achieved by overcoming the limits of standard research tools and methods. To what do you attribute your success?

Antibody 52

Antibody Gene Therapy Gene In-Vitro 52

Drug Discovery World

JUNE 7, 2023

LC : As we describe in Nature Reviews Cancer (NRC), scientists have known since the 1970s that tumours were populated by immune cells; however, it took several years of pre-clinical studies to prove that macrophages were key players in tumour progression. DS: It is now thought that TAMs support tumour cell survival.

In-Vivo 52

In-Vivo Gene Editing Engineer Bioinformatics 52

pharmaphorum

FEBRUARY 3, 2021

Dr Jennifer Harbottle, senior scientist in the R&D Base Editing team of PerkinElmer’s Horizon Discovery business, looks at progress made in the realms of biotechnology and next-generation diagnostics, vaccines and therapeutics, including the application of CRISPR-Cas9 gene editing in developing and refining cell therapies.

Gene Editing 98

Gene Editing Gene DNA Engineer 98

Worldwide Clinical Trials

MAY 30, 2024

was withdrawn, rendering it unapproved for patient use, based on negative review comments by the Committee for Medicinal Products for Human Use. Additional research is underway using gene editing via CRISPR, primarily investigating genes with known relationships to ALS, such as SOD1 and C9orf72. The MAA file in the E.U.

Gene 204

Gene Clinical Trials Clinical Trials Gene Therapy 204

Drug Discovery World

AUGUST 2, 2022

CureHeart is using gene therapy technologies to edit or silence the faulty genes that cause inherited heart muscle diseases. . It’s estimated that one in 250 people worldwide are affected by genetic cardiomyopathies, with a 50:50 risk they will pass their faulty genes on to each of their children. . CureHeart .

Gene Editing 52

Gene Editing Gene Research Genetics 52

XTalks

FEBRUARY 11, 2021

Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. Here is a profile of some of those brilliant women who helped shape genetics research.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. In addition, iPSC lines, despite their pluripotency, have skewed suitability towards certain cell types 12,13.

Gene Editing 52

Gene Editing Gene Engineer DNA 52