Scienmag

JULY 4, 2025

Among the crucial revelations was the alteration in expression patterns of genes involved in synaptic signaling, neural connectivity, and immune response modulation. The research exposed a remarkable reorganization in the developmental trajectories of neuronal and glial populations within the affected brains. Velmeshev, D.,

Gene Expression 52

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Scienmag

JULY 1, 2025

The ability to confine editing activity spatially reduces systemic exposure risks and immune responses, improving patient outcomes. Furthermore, the non-invasive light source facilitates repeated treatments, enabling dynamic therapeutic regimens responsive to disease progression or remission.

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Scienmag

JUNE 29, 2025

Instead, late-onset preeclampsia exhibited systemic biological signatures involving immune response and hepatic pathways, emphasizing a more localized and temporally delayed pathophysiology. Nature Medicine. On average, LOPE was predicted roughly 14.9 On average, LOPE was predicted roughly 14.9 3] Muñoz-Blat, R.,

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XTalks

JANUARY 6, 2025

In a groundbreaking move for pediatric medicine, the US Food and Drug Administration (FDA) has approved Ryoncil (remestemcel-L) , the first mesenchymal stromal cell (MSC) therapy ever approved in the US. Ryoncil, administered via intravenous (IV) infusion twice a week for four weeks, provides an option for those who fail steroid therapy.

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Worldwide Clinical Trials

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

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XTalks

APRIL 1, 2025

It occurs when immune cells from the donor perceive the host tissues as foreign and subsequently initiate an immune response against them. Despite the use of corticosteroids as the standard first-line treatment, many patients fail to achieve a sustained response, leading to high rates of morbidity and mortality.

Immune Response 94

Immune Response Trials Licensing Licensing 94

Scienmag

JUNE 19, 2025

This transient expression can also be advantageous where temporary modulation of immune response is desired. As the field embraces this innovation, broader applications across infectious diseases, transplant medicine, and tolerance induction in autoimmune pathologies appear increasingly attainable.

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Scienmag

JUNE 18, 2025

Essentially, peptides expressed within the CNS share structural similarities to bacterial antigens, tricking these T cells into mounting an immune response against self-tissues. In the absence of functional regulatory T cells, T_comm cells escape immune checkpoints, gaining access to the CNS and unleashing inflammatory responses.

Immune Response 75

Immune Response Bacteria Production Research 75

Scienmag

JUNE 20, 2025

The data revealed, for example, clusters characterized by heightened systemic inflammation and abnormal endothelial function, indicating a hyperactive immune response as a driver of vascular injury. Importantly, the translational impact of these findings is far-reaching.

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Research Immune Response Big Data Development 81

XTalks

FEBRUARY 5, 2025

Avtozma is a recombinant humanized monoclonal antibody that acts as an interleukin 6 (IL-6) receptor antagonist that works by targeting specific inflammatory proteins to dampen immune responses. Avtozma was submitted for regulatory approval to the FDA in January 2024 and the European Medicines Agency (EMA) in February 2024.

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Scienmag

JUNE 17, 2025

At the forefront of this paradigm shift is Professor Diego di Bernardo, Genomic Medicine Program Coordinator at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and Professor of Biomedical Engineering at the University of Naples “Federico II.” His groundbreaking project, DIMERCIRCUITS, backed by a prestigious €2.5

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Scienmag

JULY 3, 2025

The data indicate that preservation of a diverse and functional endogenous T-cell pool correlates with sustained remission, suggesting that immune system resilience beyond CAR-T cells themselves is a vital component of therapeutic success.

FDA Approval 85

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Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug. References Bilea, A. 2024, June 19). Overcoming Regulatory Hurdles in the Development of Biosimilars. link] KBDNA. 2024, May 17).

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Scienmag

JUNE 29, 2025

Developing minimally invasive diagnostic assays to monitor transplant recipients dynamically and non-invasively could revolutionize post-transplant care, enabling timely intervention and personalized medicine applications. Immune response after pig-to-human kidney xenotransplantation: A multimodal phenotyping study. Williams, C.,

Bioinformatics 59

Bioinformatics Genetics Immune Response Gene 59

Scienmag

JULY 7, 2025

By reducing off-target deamination, the evolved BEs substantially mitigate risks such as undesired mutagenesis and immune responses triggered by unintentional edits, bolstering the overall safety profiles necessary for regulatory approvals and eventual human trials.

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Genomics Genome Genotype Engineer 59

Scienmag

JUNE 7, 2025

This revelation marks a significant advancement in neonatal medicine, suggesting that the simple and widely accessible blood group typing could be an invaluable prognostic tool in neonatal intensive care units (NICUs) worldwide.

Genetics 59

Genetics Immune Response Medicine Research 59

Scienmag

JULY 11, 2025

Traditionally viewed through the lens of chronic inflammation and arrested alveolar development, BPD’s progression appears further complicated by immune alterations typical of atopic disorders. Personalized medicine approaches that tailor therapy based on atopic status could revolutionize care paradigms for BPD-affected children.

Allergies 59

Allergies Research Immune Response Genetics 59

Scienmag

JULY 3, 2025

What sets this study apart is the identification of a glutamatergic signaling axis outside the central nervous system, highlighting a novel paradigm where neurotransmitter-like molecules serve as pivotal modulators of immune responses within the liver.

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In-Vivo Genetics In-Vitro Gene Expression 52

Scienmag

JUNE 17, 2025

Winter challenges longstanding assumptions about the ineffectiveness of immunotherapy in treating pancreatic adenocarcinoma, one of the deadliest and most treatment-resistant cancers known to medicine. Pancreatic cancer is characterized by notoriously low survival rates and a limited arsenal of effective therapeutic options.

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XTalks

JULY 7, 2025

The immunotherapy tool uses AI to train the immune system to recognize and eliminate cancer cells by modifying those cells to resemble known pathogens like measles. This innovative approach prompts a stronger and more effective immune response compared to traditional immunotherapies.

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Pharmaceutical Technology

JUNE 13, 2025

The technology utilises outer membrane vesicles (OMVs) to deliver antigens, often eliminating the need for adjuvants while triggering the immune response. Discovered and developed by GSK’s global health team scientists, the GMMA technology is a low-cost platform ideal for creating vaccines in resource-limited settings.

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Scienmag

JUNE 18, 2025

The implications extend to understanding neuroinflammatory pathways, given that glial cells orchestrate immune responses within the brain. Targeting these intercellular signaling pathways may one day inform therapeutic strategies to delay or mitigate age-related cognitive decline.

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Protein Gene Expression Immune Response Research 59

Scienmag

JUNE 23, 2025

According to Dr. Martial Ndeffo-Mbah, an assistant professor at Texas A&M’s College of Veterinary Medicine and Biomedical Sciences, leveraging smartwatch technology on a grand scale could allow for a proactive approach to public health.

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Research Immune Response Medicine Development 59

Scienmag

JULY 16, 2025

This compendium of evidence collectively positions the ImP-I1R axis as a critical driver of inflammation and atherosclerosis, illuminating a previously uncharted mechanism by which gut microbiota metabolites orchestrate systemic immune responses with pathological consequences.

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Gene Expression Genetics Protein Immune Response 69

Scienmag

JULY 5, 2025

Historically, the immune system’s metabolic underpinnings were perceived as secondary to genetic and signaling pathways. However, the recent paradigm shift places cellular metabolism at the forefront of immune regulation. Such precision medicine strategies could revolutionize how immune-related diseases are treated and prevented.

Immune Response 59

Immune Response Gene Expression Regulation Gene 59

Scienmag

JULY 3, 2025

Personalized medicine approaches incorporating TCF3 and TMBIM6 expression profiling could refine patient selection, tailoring treatments to exploit the ferroptotic vulnerabilities unique to each tumor’s molecular makeup.

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Regulation Gene In-Vivo In-Vitro 59

Scienmag

JULY 5, 2025

This metabolic flexibility allows TILs to endure and proliferate within the challenging tumor niche, providing a rationale for therapeutic strategies aimed at boosting FAO pathways to empower immune responses. Moreover, the metabolite phosphoenolpyruvate (PEP) has emerged as an important modulator of T cell signaling and function.

Immune Response 86

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Scienmag

JUNE 17, 2025

These structural deteriorations not only affect cutaneous architecture but also perturb cellular signaling pathways that regulate systemic metabolic and immune responses. The degradation products of the ECM may serve as bioactive molecules that influence distant tissues, suggesting a systemic ripple effect initiated at the skin level.

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Scienmag

JUNE 30, 2025

Moreover, the study delves into the interplay between mutant p53-induced SH3BGRL expression and immune evasion. Engulfment of immune cells, such as tumor-infiltrating lymphocytes or macrophages, could impair anti-tumor immune responses, thereby fostering an immunosuppressive niche favorable to tumor expansion.

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Protein Gene In-Vivo In-Vitro 59

Scienmag

JUNE 12, 2025

image: Virginia Tech cancer researcher Jennifer Munson’s bioengineered stromal cells — which include fibroblastic reticular (left) and endothelial cells (right) — are the framework within a lymph node that provide structure, guide immune cell movement, and can influence the immune response.

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Scienmag

JULY 14, 2025

Beyond surface markers, YB328-conditioned BMDCs secreted significantly higher quantities of IL-12p70, a cytokine critical for Th1 immune responses and cytotoxic T lymphocyte activation. This finding signifies enhanced intracellular signaling fidelity and robust gene expression programs facilitating effective immune responses.

Immune Response 59

Immune Response In-Vivo Gene Expression Production 59

Scienmag

JUNE 25, 2025

In the relentless battle against glioblastoma (GBM), one of the deadliest primary brain cancers known to medicine, researchers have unveiled a groundbreaking method to decode the complex cellular conversations occurring within the tumor microenvironment.

Genetics 75

Genetics RNA In-Vivo Research 75

Scienmag

JUNE 24, 2025

Tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs) congregate within the tumor niche, creating an immunosuppressive microenvironment that shields cancer cells from cytotoxic immune responses.

Immune Response 59

Immune Response Gene Genomics Genome 59

The Pharma Data

JUNE 25, 2025

The designation is reserved for medicines aimed at treating rare diseases that affect fewer than 200,000 people annually in the United States. With the orphan drug designation now granted, riliprubart becomes a promising investigational therapy positioned to fill a significant unmet need in this complex therapeutic area.

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Scienmag

JUNE 19, 2025

In the complex landscape of pediatric inflammatory disorders, two conditions—Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C)—have emerged as focal points of scientific inquiry due to their overlapping clinical presentations and the enigmatic roles of immune cells involved in their pathology.

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The Pharma Data

JUNE 15, 2025

Sarepta Takes Action to Strengthen ELEVIDYS Safety Measures in Non-Ambulatory Duchenne Patients Sarepta Therapeutic a leading innovator in precision genetic medicine for rare disorders, today provided a significant safety update for ELEVIDYS (delandistrogene moxeparvovec-rokl). ELEVIDYS is currently the only U.S.

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Scienmag

JULY 4, 2025

Moreover, the baby’s exposure to maternal vaginal microbiota—believed to be vital in shaping a robust neonatal immune response—is conspicuously absent in planned cesarean deliveries. Achieving robust statistical power demands immense sample sizes, which this study approaches through Sweden’s comprehensive national registers.

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