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Beam makes USD 120M bet; GRAIL and Quest announce the collaboration; Brain organoids mimic infant’s brains; Improvement in T cells to kill cancer

Delveinsight

Beam Therapeutics has taken over a startup whose technology could proffer the biotech’s genetic medicines to more tissues in the body, widening the potential to approach more diseases. Cambridge, Massachusetts-based Beam aims to make more precise edits with genetic medicines, which employ base-editing.

DNA 52
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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. Early in infection, it appears that host cellular proteins are in defense mode against Ebola virus polymerase and the viral genetic material.

Protein 52
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Sponsored content: Why choose Bethyl antibodies for your R&D

Drug Discovery World

Bethyl antibodies are highly regarded for passing strict validation testing before arriving in customer hands. Pillar 5: Protein OE/Epitope Tags. Pillar 6: Genetic Strategies. The principles that have guided our rigorous validation practices for decades preceded a publication (Uhlen et al.,

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What challenges does the advanced therapies sector face? 

Drug Discovery World

Lentivirus strategies are one of the most widely used tools in biomedical research and clinical testing, says Stella Vnook, CEO, Likarda. “Dr Dr Naldini open new doors for cures for otherwise untreatable genetic diseases with the full impact of his work still untapped”, she said.

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Drug Combo May Be Safe, Effective Therapy for Rare Leukemia

The Pharma Data

The disease is a subtype of ALL in which the cancer cells have a genetic abnormality called the Philadelphia chromosome (Ph). Traditionally, Ph-positive ALL had a poor prognosis, but in the past two decades that has changed with the introduction of drugs that target the genetic anomaly. The patients were followed for up to two years.

Drugs 52
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Sprycel Plus Blincyto Drug Combo May Be Safe, Effective Therapy for Rare Leukemia

The Pharma Data

The disease is a subtype of ALL in which the cancer cells have a genetic abnormality called the Philadelphia chromosome (Ph). Traditionally, Ph-positive ALL had a poor prognosis, but in the past two decades that has changed with the introduction of drugs that target the genetic anomaly. The patients were followed for up to two years.

Drugs 52
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After a slow start for expensive CAR-T therapies, drug developers revisit oral therapies for blood cancer

pharmaphorum

price tag of $475,000 when it was first launched in 2017 – and it becomes apparent that these may not be desirable treatment options for every patient and in every setting. Add to this the considerable cost of these medications – the first approved CAR-T, Novartis’ Kymriah (tisagenlecleucel), had a U.S. CellCentric, a U.K-based