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Grand Rounds January 26, 2024: Advancing the Safe, Effective and Equitable Use of AI in Healthcare (Mark Sendak, MD, MPP; Suresh Balu, MD, MBA)

Rethinking Clinical Trials

DIHI built a modular infrastructure to support many projects via a flexible data pipeline technology infrastructure that started with one model and now includes dozens of models. There is a need for support of infrastructure to bring AI partnerships to low resource settings. The next key decision point is clinical integration.

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Grand Rounds March 24, 2023: From Observational Studies to Pragmatic Clinical Trials: (Almost) A Decade of Research in PCORnet® (Erin Holve, PhD, MPH, MPP; Russell Rothman, MD, MPP; Schuyler Jones, MD; Neha Pagidipati, MD, MPH)

Rethinking Clinical Trials

                                           Speakers Erin Holve, PhD, MPH, MPP Chief Research Infrastructure Officer, Patient-Centered Outcomes Research Institute (PCORI) Russell Rothman. We have to continue to make strides to improve our clinical trial infrastructure and how we do studies.

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Orphan drugs and where to launch them: The keys to Europe’s forgotten territories

Pharmaceutical Technology

Due to the high price tags associated with these speciality medicines, innovators have naturally favoured big markets with high GDP such as the US and EU-5 (Germany, France, Spain, Italy, and the UK). “The By leveraging the wholly-owned operational infrastructure of its parent company. Go-to-market strategies.

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Grand Rounds October 13, 2023: Incorporating Social Determinants of Health Into PCORnet (Keith Marsolo, PhD)

Rethinking Clinical Trials

In 2021-2022, PCORI contracted with NORC at the University of Chicago to undertake a series of convenings to consider data infrastructure enhancements to PCORnet. A social determinants of health convening built upon efforts of prior PCORnet SDOH workgroup and included survey development, key informant interviews, and public webinars.

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Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)

Rethinking Clinical Trials

The preparation work started with an idea in 2010, which led to selection of the pilot study in 2014 to test out the system for randomizing patients within the existing infrastructure. The actual startup was about 18 months.

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Grand Rounds June 2, 2023: PROACT Xa and The Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial (John Alexander, MD, MHS)

Rethinking Clinical Trials

A lot of this has to do with the infrastructure, PROACT tapped into a unique device infrastructure. Tags #pctGR, @Collaboratory1 The post Grand Rounds June 2, 2023: PROACT Xa and The Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial (John Alexander, MD, MHS) appeared first on Rethinking Clinical Trials.

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Grand Rounds January 20, 2023: Collaborative Pragmatic Trials in Action: EVOLVE-MI (Mikhail Kosiborod, MD)

Rethinking Clinical Trials

EVOLVE-MI has trial design and infrastructure innovations, including automated data collection and leveraging Swedish registries. Tags #pctGR, @Collaboratory1 The post Grand Rounds January 20, 2023: Collaborative Pragmatic Trials in Action: EVOLVE-MI (Mikhail Kosiborod, MD) appeared first on Rethinking Clinical Trials.

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