Sanders takes aim at US drug prices of Novo’s Ozempic and Wegovy
Pharmaceutical Technology
APRIL 25, 2024
A Senate Committee is investigating the “outrageously high” US price tags of the blockbuster diabetes and obesity drugs.
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Orchard sets new gene therapy price tag at $4.25M—the steepest of any drug in the US
Fierce Pharma
MARCH 20, 2024
After scoring an FDA nod Monday for the first gene therapy to treat the rare genetic disease metachromatic leukodystrophy (MLD) in the U.S., Kyowa Kirin and its subsidiary Orchard Therapeutics have | After scoring an FDA nod Monday for the first gene therapy to treat the rare genetic disease metachromatic leukodystrophy in the U.S.,
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Orchard’s MLD gene therapy becomes costliest US medicine
pharmaphorum
MARCH 20, 2024
Orchard Therapeutics has revealed the US price of Lenmeldy, its gene therapy for rare disease MLD, placing a $4.25m price tag on the one-shot treatment
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bluebird bio wins back-to-back landmark FDA approvals for first-in-class gene therapies
Pharmaceutical Technology
SEPTEMBER 30, 2022
Spark Therapeutics’ Luxturna, indicated for inherited retinal disease (IRD), was the first gene therapy to be approved, in 2017, with a price tag of $850,000 for each eye. Prior to bluebird's approvals, there were only two FDA-approved gene therapies for inherited conditions on the market.
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Cost of disease-modifying therapies for multiple sclerosis continues to rise in US
Pharmaceutical Technology
MAY 19, 2023
DMTs for MS have a high price tag, particularly in the US. According to GlobalData’s recent Multiple Sclerosis: Seven-Market Drug Forecast and Market Analysis to 2030 – Update report, which identified 19 DMTs marketed for MS in the US, the average annual cost of therapy increased by 9% between 2020 and 2022.
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Global (68M) cardiomyopathies market projected to grow to $9.63bn by 2031
Pharmaceutical Technology
DECEMBER 15, 2022
The US is set to dominate the cardiomyopathy landscape because of the country’s high prevalence of dilated cardiomyopathy (DCM) relative to the other markets in the 7MM, as well as the higher price tag on US-marketed therapeutics. of sales in 2021 and 2031 respectively. of global cardiomyopathies sales in 2021 and 31.2%
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Grand Rounds May 5, 2023: All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine (Joshua C. Denny, MD, MS)
Rethinking Clinical Trials
MAY 10, 2023
Denny, MD, MS CEO, All of Us Research Program Slides Keywords Precision Medicine, All of Us Research Program Key Points The mission of the All of Us Research Program is to accelerate health research and medical breakthroughs, enabling individualized prevention, treatment, and care for all of us.
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STAT+: Pharmalittle: Vertex exec says prices for gene therapies are ‘in the ballpark’; insulin access in poor countries remains spotty
STAT News
OCTOBER 6, 2022
And this is especially true for us, since we hit the proverbial pause button yesterday to observe ancient rituals. Please feel free to join us. million tag as cost effective for a Bluebird Bio drug called Zynteglo for the blood disorder beta thalassemia, Arbuckle said in an interview. Our choice today is Jack Daniels.
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Biogen, Eisai Alzheimer’s drug lecanemab fast tracked by FDA
pharmaphorum
DECEMBER 24, 2021
The anti-amyloid drug, which also claimed a breakthrough tag from the FDA in July, is being developed for the treatment of early-stage Alzheimer’s disease. The $56,000-a-year price tag for the drug, which has now been cut in half in the US, also hasn’t helped the drugmakers make a case for Aduhelm with US payers.
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Google’s 2021 Title Shakeup Part 1: What Pharma Marketers Should Know
Intouch Solutions
NOVEMBER 17, 2021
blue links) of the organic results appeared to be pulling from content outside of the HTML title tag at a much higher frequency. Title Tag – This is an HTML element that provides a title for the page. It can be seen by hovering over the browser tab and has often been used to populate the SERP Title. Source: Google.
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Risk-sharing agreements are growing at a rate of 24%
Pharmaceutical Technology
FEBRUARY 10, 2023
This is not the first treatment to come with a high price tag. Access to oncology medicines varies across countries, and their cost against safety/efficacy is generally perceived as being low, such as in the US. million, according to GlobalData’s Price Intelligence (POLI), making it the most expensive drug in the world.
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Versanis’ bimagrumab, first-in-class obesity therapy, enters Phase IIb of development
Pharmaceutical Technology
JANUARY 17, 2023
On January 12, Versanis Bio announced that enrollment had begun for its Phase IIb trial, BELIEVE (NCT05616013), which aims to study bimagrumab’s (BYM-338) efficacy and safety in the US, among other locations. Mounjaro is anticipated to launch in the US later this year or by early 2024.
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Google’s 2021 Title Shakeup Part 2: Our SERP Title Analysis Study
Intouch Solutions
NOVEMBER 30, 2021
blue links) of the organic results appeared to be pulling from content outside of the HTML title tag at a much higher frequency. SERP Titles vs H1 Elements Comparisons: SERP Titles were compared to the page’s title tag and H1 element for each date range. Aim for title tags between 45 and 60 characters. Considerations.
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Can gene therapies for haemophilia defend their high price tags?
Pharmaceutical Technology
NOVEMBER 9, 2022
Since its FDA approval in August 2022, the beta-thalassemia therapy was launched in the US with a $2.8 million price tag. The value calculation behind Roctavian’s suggested price relies on the current expenses that haemophilia A patients face in the US. The post Can gene therapies for haemophilia defend their high price tags?
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Patent wars: what’s behind Amgen’s possible win over Sanofi at the US Supreme Court
Pharmaceutical Technology
FEBRUARY 22, 2023
Amgen could be the winner of a high-stakes patent spat with Sanofi as tensions run high weeks before the March 27 US Supreme Court hearing. Both drugs come with a high price tag. Since April 2020, Sanofi is responsible for Praluent outside of the US, while Regeneron handles its sale in the US.
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The Lancet Global Health: Modelling study estimates health-care cost of COVID-19 in low- and middle-income countries at US$52 billion every four weeks
Scienmag
SEPTEMBER 9, 2020
Massive price tag of COVID-19 response in 73 low- and middle-income countries underscores benefits of investing in pandemic preparedness New modelling research, published in The Lancet Global Health journal, estimates that it could cost low- and middle-income countries (LMICs) around US$52 billion (equivalent to US$8.60
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Cannabinoids receptors: popular preclinical target but banned in 137 countries
Pharmaceutical Technology
DECEMBER 5, 2022
Collectively, cannabinoid receptors (CB1 and CB2) are currently the most popular targets in preclinical stage of development, with 391 drugs tagged in total. In the US, the world’s largest pharmaceutical market, most states have legalized cannabinoids for medical use.
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Amylyx ALS drug draws criticism over $158,000 price tag
pharmaphorum
OCTOBER 3, 2022
Amylyx Pharmaceuticals’ Relyvrio – a new treatment for amyotrophic lateral sclerosis (ALS) approved by the FDA on Thursday, after review of the data from its phase 2 trial – was the next day set at a list price of $158,000 per year in the US, sparking outcry. ALS affects over 30,000 people in the US.
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Grand Rounds February 16, 2024: Clinical Implications of the MINT Trial: p=0.07 (Jeffrey Carson, MD, MACP)
Rethinking Clinical Trials
FEBRUARY 20, 2024
One of our reviewers was incredibly helpful in helping us frame the relative risk confidence interval concepts that I described, which helped us shape the language. I think that the journal bought into that and helped us do it. There were differing opinions. It wound up being a very collaborative, constructive process.
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Orphan drugs and where to launch them: The keys to Europe’s forgotten territories
Pharmaceutical Technology
JULY 14, 2022
Most famously, the US passed its Orphan Drug Act in 1983, providing innovators with financial motivation to develop orphan drugs and meet the needs of these forgotten patients. These countries will have a smaller patient pool due to population size and will likely carry a price tag that is significantly below that of higher GDP countries.”.
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Rare Disease Spotlight – tracing the rise of orphan drug designations over almost 40 years
Pharmaceutical Technology
JUNE 29, 2022
The US Food and Drug Administration (FDA) put a high-profile bluebird bio trial for sickle cell disease on partial clinical hold, and advisory panels deliberated over decisions involving gene therapies for amyotrophic lateral sclerosis (ALS), cerebral adrenoleukodystrophy (CALD), and beta-thalassemia.
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First gene therapy for haemophilia B gets go ahead in Europe
Drug Discovery World
DECEMBER 20, 2022
The therapy was also recently approved by the FDA for patients in the US. . Thank you to all for the role you have played in helping us reach this regulatory milestone in Europe.” . A one-time treatment with etranacogene dezaparvovec costs US$3.5 World’s most expensive drug.
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Roche’s Early Alzheimer’s Blood Test Gets FDA Breakthrough Device Designation
XTalks
APRIL 18, 2024
Roche has received Breakthrough Device designation from the US Food and Drug Administration (FDA) for its Elecsys pTau217 early Alzheimer’s blood test. million people live with Alzheimer’s disease in the US with the number of cases expected to rise to 13 million by 2050. The disease has an estimated $360 billion cost to the US economy.
A broad range of unmet needs remains in the immuno-oncology space
Pharmaceutical Technology
MAY 2, 2023
High-prescribing physicians surveyed by GlobalData across eight major markets (8MM: US, France, Germany, Italy, Spain, UK, Japan, and China) identified a broad range of unmet needs in the IO space (see Figure 1). Despite the significant advances that have been made in the IO field, a huge level of unmet need remains.
Lyfgenia and Casgevy Become First FDA-Approved Gene Therapies for Sickle Cell Disease
XTalks
DECEMBER 13, 2023
The US Food and Drug Administration (FDA) has approved the first gene therapies for the treatment of sickle cell disease, approving two on the same day. Casgevy is also the first ever CRISPR/Cas9-based therapy approved in the US. Vertex-CRISPR’s Casgevy has a US list price of $2.2 Both therapies will be available in early 2024.
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Drug-resistant epilepsy drug Ontozry backed by NICE
pharmaphorum
NOVEMBER 16, 2021
“The FAD is a significant milestone for cenobamate and takes us closer towards reimbursement in England and Wales,” commented Stuart Mulheron, general manager UK & Ireland, Angelini Pharma. An opinion from the Scottish Medicine Consortium (SMC) on the use of the drug by NHS Scotland is expected to be published early in 2022.
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How pharma marketing can stay ahead of the evolving customer journey
pharmaphorum
JULY 23, 2019
This pharmaphorum webinar, in association with Tag, will examine the challenges that pharma marketing faces to stay ahead of the evolving customer journey and offer expert insight from both the pharma and FMCG sectors on how to convert these challenges into opportunities.
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Scientists and medics turn to TikTok to reassure public on vaccine safety
pharmaphorum
DECEMBER 17, 2020
TikTok itself meanwhile says it has taken steps to make sure its users have access to reliable information about the pandemic, which will be stepped up as immunisation programmes start in the UK, US and elsewhere.
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Anti-Counterfeiting Technologies in Healthcare
Roots Analysis
MARCH 1, 2024
Such disadvantages of overt security technologies can be overcome using certain covert security features. The examples of unique codes used for such purposes include linear or 2-dimensional barcodes, human- readable combinations of letters / numbers or unique serialized codes that can be written onto an RFID tag or label.
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Grand Rounds October 13, 2023: Incorporating Social Determinants of Health Into PCORnet (Keith Marsolo, PhD)
Rethinking Clinical Trials
OCTOBER 18, 2023
First steps are getting the data in such a state that would allow us to learn about some of those social determinants of health. Tags #pctGR, @Collaboratory1 The post Grand Rounds October 13, 2023: Incorporating Social Determinants of Health Into PCORnet (Keith Marsolo, PhD) appeared first on Rethinking Clinical Trials.
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Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)
Rethinking Clinical Trials
FEBRUARY 14, 2024
When people understood what we were trying to do, embed research into clinical care, people really engaged and a few regional directors made participation one of the drivers of research in their region and helped us get initial groundwork.
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Novo Nordisk’s Ozempic Shortage Spurs Demand for Eli Lilly’s Diabetes Injection Mounjaro
XTalks
NOVEMBER 3, 2022
In its first quarter on the market since its approval, sales totalled $97 million between July and September in the US. Since its US approval in June of last year, demand for Novo’s weight loss drug Wegovy has been skyrocketing, and with a recent informal endorsement from Elon Musk on Twitter , demand is only expected to further increase.
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Grand Rounds February 3, 2023: Pragmatic Trials For Children With Congenital Heart Disease – Insights From The NITRIC Trial (Luregn Schlapbach, PhD, FCICM)
Rethinking Clinical Trials
FEBRUARY 13, 2023
Our study gave us a unique power to understand what happens after newborn cardiac surgeries. Tags #pctGR, @Collaboratory1 The post Grand Rounds February 3, 2023: Pragmatic Trials For Children With Congenital Heart Disease – Insights From The NITRIC Trial (Luregn Schlapbach, PhD, FCICM) appeared first on Rethinking Clinical Trials.
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Grand Rounds Ethics and Regulatory Series September 9, 2022: Building An Academic Learning Health System: Why Is It So Hard? (Steven Joffe, MD, MPH)
Rethinking Clinical Trials
SEPTEMBER 16, 2022
It is incumbent on all of us, and it should be a central part of the goal for all of us to deliver care to patients and families. Given what we know in the gap between the care that is possible and care that is delivered, there is an ethical imperative to pursue the learning mission. Learn more. More info: [link].
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Will Plant-Based Meat Prices Ever Be Lower Than Real Meat?
XTalks
JULY 16, 2021
There are several factors to consider, and understanding them will help us to answer the ultimate question: will plant-based meat ever be cheaper, or at least on par, with real meat? But yet, the price tag is still higher than real meat. A pound of Beyond Meat’s Beef burgers carries a price tag of $6.25, Vox reported.
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Free access to Zolgensma curbed, says Novartis
pharmaphorum
JANUARY 9, 2023
” Zolgensma is one of the most expensive therapies available, with a price tag of around $2.1 million in the US and just under €2 million in Europe, which the company says is justified by its dramatic benefits when given as a one-shot therapy to patients with SMA.
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Blue Note leukaemia DTx gets FDA breakthrough tag
pharmaphorum
JANUARY 11, 2022
It has since been joined by other products in the software as a medical device (SaaMD) category, including Pear Therapeutics’ alcohol-use disorder candidate Pear-009 and another Blue Note DTx, codenamed BNT001, which is also being tested for anxiety and depression in cancer patients.
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Immunocore gets EU nod for TCR cancer therapy Kimmtrak
pharmaphorum
APRIL 5, 2022
Kimmtrak (tebentafusp) has been cleared to for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma (mUM), mirroring its label in the US. The European population is meanwhile estimated at several thousand patients, across all stages, according to registry data.
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Second unanimous FDA adcomm vote boosts bluebird bio
pharmaphorum
JUNE 12, 2022
The FDA still has to deliver its own verdict on the applications, and doesn’t always follow its advisors’ lead, but with two unanimous decisions bluebird looks set up for its first approvals in the US. Beti-cel has already been approved for marketing in Europe as Zynteglo, with a price tag of around $1.8
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FDA begins review of Samsung Bioepis/Biogen’s Lucentis biosimilar
pharmaphorum
NOVEMBER 19, 2020
Novartis/Genentech’s eye drug Lucentis could be the next big blockbuster to face competition from cheaper biosimilars after its US patent expired this year – and Samsung Bioepis and Biogen are closing in after the FDA accepted a filing for their cut-price rival.
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Immunocore’s Kimmtrak Gets FDA Approval as First Treatment for Rare Eye Cancer and First T Cell Receptor Therapeutic
XTalks
JANUARY 28, 2022
Immunocore received Breakthrough Device Designation for Kimmtrak from the FDA in February 2021 followed by acceptance of its Biologics License Application (BLA) several months later by both US and European regulators. Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose.
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American health is in for a “world of hurt”
World of DTC Marketing
NOVEMBER 3, 2020
Cardiovascular disease deaths in the US have increased by nearly 17% since 2010, and are among the reasons that life expectancy in the U.S. is lower than in other high-income countries. has also seen reversals in health improvements since 2010, partly due to increasing rates of obesity, high blood pressure, and high blood sugar. .
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How COVID-19 Changed Food Sampling in Retail and At Home
XTalks
AUGUST 25, 2021
But without food sampling, consumers may not be able to justify the $6 price tag, let alone be aware of the brand. . We actually reached out to the hospitals, hospitals reached out to us and they actually wanted to work with us to help us in business,” said Jake Karls, co-founder of Mid-Day Squares.
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Preview of Pharma Commercials at Super Bowl 2024: From Touching Down with TUMS to Tackling Menopause
XTalks
FEBRUARY 8, 2024
Along with the hefty price tag for screen time that may not be perceived to be a worthwhile investment, and despite favoring advertising at other major events like the Grammys, pharma tends to stay somewhat clear of all the Super Bowl hoopla.
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