Scienmag

MAY 11, 2021

An international team of researchers at Great Ormond Street Hospital (GOSH), and University of California, Los Angeles (UCLA) have developed a gene therapy that successfully treated 48 out of 50 children with a form of severe combined immunodeficiency that leaves them without an immune system.

Gene Therapy 73

Gene Therapy Gene Development Research 73

XTalks

NOVEMBER 30, 2023

The safety and efficacy of Cabenuva were established through two randomized, open-label, controlled clinical trials involving 1,182 HIV-infected adults who were virologically suppressed (HIV-1 RNA less than 50 copies/mL) before initiating Cabenuva treatment. Additionally, Gag-specific CD8+ T cells demonstrated an increase of 1.7

FDA Approval 111

FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

Scienmag

AUGUST 14, 2020

Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known as rucaparib Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with (..)

Clinical Trials 57

Clinical Trials Clinical Trials Gene Trials 57

pharmaphorum

JULY 26, 2022

The hope of being able to provide a functional or complete cure for AIDS is being raised by the prospect of utilising recent developments in the industry, including gene therapy and mRNA vaccines. Gene therapies are another approach that has been validated with approvals in recent years.

Gene Therapy 139

Gene Therapy Protein Vaccination Vaccine 139

Olympian Clinical Research

JUNE 10, 2022

This condition occurs when a gene variation causes the skin to become dry and irritated. Food allergies. Food allergies. Find a Clinical Trial for Atopic Dermatitis. However, If you are looking for additional relief, you may want to consider enrolling in a clinical trial. Excessive sweating.

Allergies 98

Allergies Clinical Trials Clinical Trials Clinical Research 98

Drug Discovery World

FEBRUARY 20, 2023

Breast cancer retained its position as the most-studied disease area in clinical trials in 2022, according to a recent report by analytics company Phesi. Clinical trials continue to determine whether Lutetium-177 PSMA-617 provides a survival benefit to patients who have not previously received chemotherapy.

Drug Trials 52

Drug Trials Trials Clinical Trials Clinical Trials 52

Delveinsight

JANUARY 21, 2021

The new research provides a scientific rationale to advance clinical studies of the drug combination in patients with AML. The gene TP53 produces the protein p53, a known tumour suppressor. TP53 is frequently mutated across various cancers, so targeting the gene is a popular pursuit in oncology research.

Research 52

Research Protein Clinical Trials Clinical Trials 52

XTalks

DECEMBER 20, 2023

Bayer’s Astepro (azelastine), an over-the-counter medication for cold, flu and allergies, led the pack in the first half of 2023 with 7.4 9. 10 Trends and Statistics for Clinical Trials in 2023 Several key trends in clinical trials have been shaping the landscape of the field this year. billion ad impressions.

Life Science 59

Life Science Clinical Trials Clinical Trials FDA Approval 59

XTalks

DECEMBER 24, 2020

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic. CRISPR Gene Editing Inventors Win Nobel Prize.

Life Science 111

Life Science Vaccination Vaccine Gene 111

Drug Discovery World

AUGUST 1, 2023

According to the company, a single nucleotide substitution in the PNPLA3 gene results in a mutation that impairs the breakdown of fat in liver cells which raises the risk of NASH. AstraZeneca’s non-alcoholic steatohepatitis (or ‘NASH’) study is a prime example of the value of ASOs 2.

RNA 52

RNA Drugs Gene Silencing Vaccination 52

Scienmag

AUGUST 4, 2020

Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing […].

Gene Expression 82

Gene Expression Gene Scientist Research 82

The Pharma Data

JANUARY 24, 2021

With a presidential inauguration and a federal holiday, it wasn’t an enormously busy week for clinical trial news, but there was a fair amount, nonetheless. It inked a deal with the National Institute of Allergy and Infectious Diseases (NIAID) to launch a Phase I trial. Read on to see. COVID-19-Related.

Trials 52

Trials Allergies In-Vitro Antibody 52

Delveinsight

AUGUST 27, 2020

The phase 1 study that is being run by the National Institute of Allergy and Infectious Diseases tests three dose levels of the vaccine, mRNA-1273, given in two injections a month apart in 120 adults. Moderna showed robust phase 1 results for its COVID-19 vaccine in adults up to 55 last month.

Vaccination 53

Vaccination Vaccine Research Trials 53

The Pharma Data

JULY 8, 2021

8) There were no clinically meaningful differences in safety results between the tezepelumab and placebo groups in the NAVIGATOR trial.(8) About the NAVIGATOR and the PATHFINDER Clinical Trial Program. Building on the Phase 2b PATHWAY trial, the Phase 3 PATHFINDER program included two trials, NAVIGATOR8,18 and SOURCE.19,20

Allergies 52

Allergies Trials In-Vivo Medicine 52

Pfizer

SEPTEMBER 28, 2022

Pfizer-BioNTech COVID-19 Vaccine, Bivalent (Original and Omicron BA.4/BA.5), 5), COMIRNATY® (COVID-19 Vaccine, mRNA) and Pfizer-BioNTech COVID-19 Vaccine. 5) may not protect all vaccine recipients. . • You should not receive Pfizer-BioNTech COVID-19 Vaccine, Bivalent (Original and Omicron BA.4/BA.5) 5) could cause a severe allergic reaction.

Vaccination 101

Vaccination Vaccine Medicine Clinical Trials 101

Pfizer

OCTOBER 19, 2022

The Phase 1/2/3 trial ( NCT04816643 ) has enrolled more than 10,000 children ages 6 months to under 12 years of age in the United States, Finland, Poland, Spain and Brazil from more than 90 clinical trial sites. Tell your vaccination provider about all of your medical conditions, including if you: have any allergies.

Vaccination 40

Vaccination Vaccine Clinical Trials Clinical Trials 40

The Pharma Data

NOVEMBER 9, 2020

NAVIGATOR and the PATHFINDER clinical trial program Building on the Phase 2b PATHWAY trial, the Phase 3 PATHFINDER program included two trials, NAVIGATOR and SOURCE. 4,5 The program includes additional planned mechanistic and long-term safety trials. 10 World Allergy Organization (WAO). 11 Busse WW.

Trials 52

Trials Production Sales Manufacturing 52

Scienmag

OCTOBER 29, 2020

USF Health-led TEDDY analysis focuses on development of multiple distinct autoantibodies targeting insulin-producing cells, from initial autoimmunity to symptomatic type 1 diabetes Credit: Courtesy of USF Health TAMPA, Fla.

Genetics 92

Genetics Insulin Development Clinical Trials 92

The Pharma Data

SEPTEMBER 8, 2021

Real-World Evidence for Control of Patients With Chronic Migraine Who Received Calcitonin Gene?Related Patients treated for overactive bladder: In clinical trials, 36 of the 552 patients had to self-catheterize for urinary retention following treatment with BOTOX ® compared to 2 of the 542 treated with placebo.

Botox 52

Botox Doctors Doctor Medicine 52

The Pharma Data

MARCH 30, 2021

Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for atogepant, an investigational orally administered calcitonin gene-related peptide (CGRP) receptor antagonist (gepant), for the preventive treatment of migraine in adults who meet criteria for episodic migraine.

Botox 52

Botox Drugs Doctors Doctor 52

Scienmag

JUNE 17, 2021

AURORA, COLORADO, June 16, 2021 — Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the 16th International Conference on Malignant Lymphoma (ICML) (..)

Clinical Trials 40

Clinical Trials Clinical Trials Bioinformatics Allergies 40

XTalks

AUGUST 2, 2023

Meanwhile, BioMarin’s gene therapy Roctavian is approved by the FDA for the treatment of hemophilia A. 2022 was the first year on market for cell-based gene therapies Abecma (Idecabtagene vicleucel) and Breyanzi (lisocabtagene maraleucel) , which generated $388 million and $182 million, respectively. Both are anti-CD20 agents.

Sales 98

Sales Manufacturing FDA Approval Life Science 98

The Pharma Data

APRIL 27, 2021

reflecting increased competition partially offset by demand growth partly related to clinical trial supply and price upside in Europe. to €283 million, reflecting growth of Digestive and Mental Wellness categories as well as Allergy partially offset by the decline of the Pain category. Aubagio ® sales decreased 1.1% In the U.S.,

Sales 52

Sales Vaccination Vaccine Medicine 52

XTalks

SEPTEMBER 14, 2020

By the end of August, the World Health Organization (WHO) counted 33 vaccine candidates in some stage of clinical trial evaluation. Sinovac Biotech is already in Phase III clinical trials testing its CoronaVac vaccine which it plans to evaluate in approximately 11,000 volunteers. The price of that prize is incalculable.

Vaccination 92

Vaccination Vaccine Antibody Life Science 92