Drug Discovery World

APRIL 30, 2024

This eBook, sponsored by Thermo Fisher Scientific, explores the impact of monoclonal antibodies (mAbs) on the treatment of cancer, autoimmune and infectious diseases, and inflammatory conditions, as well as the latest clinical research and where the innovation in mAb development might be in the future.

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Drug Discovery World

OCTOBER 17, 2023

The DDW Turning Science into Business Summit, ‘ Cancer research opportunities and advances ’ will feature experts and thought leaders in cancer research, precision medicine and immunotherapy. Muaiad Kittaneh Dreps and Kittaneh will also explore the importance of collaboration and data sharing in antibody drug development.

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Pharmaceutical Technology

MAY 22, 2023

SM17 is a humanised IgG4-k monoclonal antibody that targets IL-17RB to treat asthma, idiopathic pulmonary fibrosis (IPF), atopic dermatitis (AD) and other immunological disorders. It can suppress Th2 immune responses by binding to IL-17RB on Type 2 innate lymphoid cells (ILC2s).

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XTalks

MAY 2, 2022

Lecanemab, the product of Phase IIb clinical research completed by BioArctic and collaborator Eisai, is one therapy making strides this year for Alzheimer’s disease. This year, the monoclonal antibody lecanemab is approaching final stages of investigation as a treatment for targeting the A? Next Stages in Clinical Research.

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Pharmaceutical Technology

MAY 12, 2023

The collaboration will use the integrated drug creation platform of Absci and the clinical immunology datasets from the Kennedy Institute to identify antibodies to immune-mediated inflammatory diseases and autoimmune conditions with unprecedented speed.

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Pharmaceutical Technology

JANUARY 17, 2023

Spain’s Hospital Universitario 12 de Octubre researchers, along with the Josep Carreras Leukaemia Research Institute, have developed a new cell therapy based on STAb cells to treat a type of leukaemia. The STAb therapy is based on a special type of bispecific antibody secretion. STAb-T therapy is on this path.”.

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XTalks

JULY 25, 2022

Later lines of treatment can include monoclonal antibodies, tyrosine kinase inhibitors and antibody-drug conjugates (ADCs). XTALKS WEBINAR: Discussing the Concerns within Clinical Research in Oncology and In-Home Healthcare. ADCs consist of an antibody attached to a cytotoxin that is delivered to targeted cells.

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The Pharma Data

NOVEMBER 22, 2020

FJB) and IONTAS Limited (IONTAS), leaders in the discovery and optimization of VHH and fully human antibodies, today announced they have signed an agreement to discover antibodies with Pandion Therapeutics (Pandion). We now have a pipeline of undisclosed therapeutic partnerships nearing clinical research.

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Medical Xpress

DECEMBER 1, 2022

In 2021, a group of scientists led by researchers at the University of North Carolina at Chapel Hill, Weill Cornell Medicine and NewYork-Presbyterian reported that the Moderna mRNA vaccine and a protein-based vaccine candidate containing an adjuvant, a substance that enhances immune responses, elicited durable neutralizing antibody responses to SARS-CoV-2 (..)

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pharmaphorum

OCTOBER 21, 2022

The acquisition of DJS Antibodies, a privately-held UK-based biotechnology company dedicated to discovering and developing antibody medicines that target difficult-to-drug disease-causing proteins – such as G protein-coupled receptors (GPCRs) – will extend AbbVie’s present discovery research capabilities, through DJS’ proprietary HEPTAD platform.

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Drug Discovery World

AUGUST 18, 2023

My chosen news stories this week all discuss pre-clinical research studies that could have a huge impact on our therapeutic approach to several hard-to-treat diseases, helping to overcome drug-resistance and make treatments more targeted in the future.

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Advarra

JANUARY 11, 2024

The applications of mRNA-based therapies in cancer research represent one of the next groundbreaking steps toward improved cancer treatments. While mRNA usage has played several roles in clinical research , oncology researchers in particular are eager to explore the possibilities of mRNA-based cancer vaccines.

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XTalks

DECEMBER 28, 2023

BillionToOne, a company specializing in molecular diagnostics, has partnered with Janssen Research & Development, LLC, a Johnson & Johnson division, to conduct the AZALEA Phase III clinical trial globally. Nipocalimab is an investigational monoclonal antibody that targets the neonatal Fc receptor.

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Delveinsight

NOVEMBER 26, 2020

Researchers from Emory and Case Western Reserve state they have got a method to succeed that challenge with a specially engineered virus. Genmab discards antibody-drug conjugate after the early-phase fiasco. Genmab is ditching an antibody-drug conjugate after it flunked the mark in early-phase trials. Clancy, M.D.,

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XTalks

MARCH 20, 2024

When it comes to leadership in clinical trials today, what qualities are necessary to navigate the evolving landscape of clinical research effectively? Xtalks recently had the opportunity to discuss Enciso’s journey in the clinical research industry and her decision to join Regeneron.

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XTalks

JANUARY 17, 2024

In this Xtalks Spotlight edition, Xtalks spoke with two oncology clinical research experts from Fortrea , Laura Vidal, MD, Medical Head of Oncology, EU (European Union), and Ken Morrison, PhD, Global Head of Strategic Delivery & Growth Oncology.

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Rethinking Clinical Trials

JANUARY 17, 2024

Any patient admitted to the hospital with COVID-19 completed a COVID intake form in their admission record, and if they opted to learn about experimental therapies, a FaceTime call was set up with a research coordinator. The first monoclonal antibody (mABs) treatment for treatment of COVID-19 was approved in November 2020.

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The Pharma Data

JANUARY 22, 2021

22, 2021 /PRNewswire/ — The Lupus Research Alliance (LRA) is excited to share that the U.S. Lupus Research Alliance President and CEO Kenneth M. Brad Rovin , Director of the Division of Nephrology and Medical Director of the Center for Clinical Research Management at the Ohio State University Wexner Medical Center.

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Drug Discovery World

MARCH 24, 2023

Pennsylvania researchers may have found a way to boost CAR-T therapy in these tumours, previously only successful in blood cancers, which could have huge implications for cancer treatment. News round-up for 20-24 March by DDW Digital Content Editor Diana Spencer.

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BioTech 365

DECEMBER 17, 2020

Brii Biosciences Provides Corporate Update on Progress Against Strategic R&D Priorities Brii Biosciences Provides Corporate Update on Progress Against Strategic R&D Priorities – Initiated clinical research of investigational monoclonal antibodies BRII-196 and BRII-198 in combination for the treatment of COVID-19 … Continue reading (..)

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Delveinsight

JANUARY 21, 2021

Researchers at the Sanford Burnham Prebys Medical Discovery Institute and the University of Glasgow have early proof a combination strategy may work in AML. The researchers stated in the journal Nature Communications. TP53 is frequently mutated across various cancers, so targeting the gene is a popular pursuit in oncology research.

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Drug Discovery World

MARCH 10, 2023

There have been several other announcements related to clinical trials in the last few days, including positive data from trials in severe influenza and biliary tract cancer, the launch of a study into an ADC treatment for solid tumours, and a new research partnership with the mission to improve clinical trial design.

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Drug Discovery World

SEPTEMBER 16, 2022

Sponsored by Regeneron and Sanofi, the study of dupilumab in poorly controlled eczema is the first large-scale randomised double-blind trial of a monoclonal antibody for any skin disease in patients aged six months to six years. It’s also incredibly stressful for their families, particularly as children’s sleep is so disturbed. .

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Drug Discovery World

FEBRUARY 19, 2024

It is approved for use in adults that have previously been treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor. This approval is transformative for the entire research field and supports continued investigation of TIL cell therapy across additional types of solid tumours.”

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Drug Discovery World

APRIL 15, 2023

The American Association for Cancer Research (AACR) Annual Meeting is taking place at the Orange County Convention Center in Orlando, Florida from April 14-19, 2023. BDC-3042 is an agonistic antibody targeting Dectin-2, an immune-activating receptor expressed by TAMs.

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Drug Discovery World

AUGUST 21, 2023

Diana Spencer has chosen news stories this week which all discuss pre-clinical research studies that could have a huge impact on our therapeutic approach to several hard-to-treat diseases, helping to overcome drug-resistance and make treatments more targeted in the future.

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Advarra

MARCH 10, 2023

Considered a rare disease, research in finding better therapies – and possibly even a cure – for SCD may be competing for funding with conditions impacting broader populations. SCD’s significant impact on African Americans also means it predominantly impacts a minority community historically underserved by clinical research.

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Crucial Data Soutions

NOVEMBER 9, 2021

CDS), a provider of innovative software to advance clinical research, announced today a new functionality on their mobile app, TrialKit, that enables people to self-enroll in global patient registries and participate in research directly from their smartphone or tablet.

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pharmaphorum

SEPTEMBER 15, 2020

Humanigen is hoping for emergency use authorisation in the US for an antibody to treat severe COVID-19 before the end of 2020, and has teamed up with Swiss contract manufacturer Lonza to make sure it can meet demand. Lilly also has studies on the go for LY3127804, an investigational antibody targeting angiopoietin 2 (Ang2).

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Drug Discovery World

DECEMBER 13, 2022

An immunotherapy that uses a new targeted approach to kill bone marrow cancer cells was successful in as many as 73% of patients in two clinical trials. . The trial results have been revealed by researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. . months with weekly dosing. .

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The Pharma Data

MARCH 11, 2021

Eli Lilly and Company (NYSE: LLY) today announced that data from programs across its oncology portfolio and pipeline will be presented at the 2021 American Association for Cancer Research (AACR) Annual Meeting, to be held virtually April 10-15, 2021. Session Category: Clinical Research (Excluding Trials). Abstract Number: 442.

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Pharmaceutical Technology

JANUARY 30, 2023

Numerous drug approval applications to the FDA failed in 2022, including oncology monoclonal antibodies (mAbs) such as Eli Lilly and Co’s (Indianapolis, IN, US) sintilimab, Y-mAbs Therapeutics Inc’s (New York, NY, US) omburtamab, and Coherus BioSciences’ (Redwood City, CA, US) toripalimab.

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XTalks

JULY 14, 2022

Over time, even the use of Krystexxa can lead to the development of antibodies against it, reducing its effectiveness. Early data also showed that methotrexate could prevent the formation of anti-drug antibodies. This is why methotrexate was paired with it, as methotrexate is used to treat inflammatory conditions like arthritis.

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pharmaphorum

DECEMBER 6, 2021

Professor Saul Faust, director of the NIHR Clinical Research Facility, who led the trial at University Hospital Southampton NHS Trust, said the vaccines were “remarkably effective immunological boosters, way above what is needed to prevent hospitalisation and death.”

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pharmaphorum

DECEMBER 12, 2022

The San Antonio Breast Cancer Symposium (SABCS) has highlighted some of the most promising clinical research being undertaken by drugmakers in the category, with AstraZeneca leading the charge with a trio of major trial readouts.

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pharmaphorum

SEPTEMBER 29, 2020

Elezanumab is a monoclonal antibody that binds selectively to repulsive guidance molecule, which is known to inhibit regeneration of neurons and functional recovery following central nervous system damage. The regulator has also granted it orphan status, which cuts development costs and potentially boosts profits if approved.

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Roots Analysis

MARCH 16, 2022

Over the years, applications of exosomes in therapeutics have undergone an evolutionary change, in terms of cost of research, technology used, and duration of the study. Published Scientific Literature: Indicative of the Ongoing pace of Research in this Field. Our Social Media Platform. Web: [link]. LinkedIn: [link]. Twitter: [link].

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