pharmaphorum

OCTOBER 1, 2021

Already a major player in atopic dermatitis with Dupixent, Sanofi looked to expand its position in the category earlier this year when it bought Kymab and its lead drug KY1005 for the skin disorder for $1.1 Now, it says the drug has delivered “exciting” results in a proof-of-concept trial. billion upfront.

Drugs 95

Drugs Antibody Dermatology Trials 95

Drug Discovery World

DECEMBER 16, 2022

A novel, patient-tailored monoclonal antibody therapy has shown promise in treating moderate to severe atopic dermatitis. . First AML patient successfully transplanted with investigational drug . The post This week in drug discovery (12-16 December) appeared first on Drug Discovery World (DDW).

Drugs 52

Drugs Vaccination Vaccine Genetics 52

Pharmaceutical Technology

FEBRUARY 18, 2023

Gevokizumab is a monoclonal antibody commercialized by Novartis, with a leading Phase I program in Metastatic Renal Cell Carcinoma. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV).

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Generic Pharmaceutical Dermatology Antibody Development 100

pharmaphorum

SEPTEMBER 16, 2022

Atopic dermatitis (AD) is a highly prevalent chronic dermatological disease, with symptoms which include itching, dry skin, severe pain, and inflammation – all of which create considerable stress in the daily lives of patients and often negatively affect their day-to-day and long-term well-being.

Dermatology 87

Dermatology Trials Drugs Development 87

pharmaphorum

OCTOBER 5, 2022

Sanofi has added to its rare disease pipeline by licensing an antibody-RNA conjugate (ARC) for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder, from US biotech miRecule. billion deal in 2018. The aim will be to identify promising candidates in areas of “unmet patient need.”

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RNA Genetics Dermatology Antibody 102

pharmaphorum

JANUARY 18, 2022

IRB Barcelona’s Dr Cristina Mayor-Ruiz, who leads the firm’s Targeted Protein Degradation and Drug Discovery lab, was recently awarded a European Research Council (ERC) Starting Grant for her work. It also builds on complementary core expertise of each partner to facilitate research and drug development.”.

Dermatology 52

Dermatology Protein Pharma Companies Research 52

Drug Discovery World

DECEMBER 13, 2022

A novel, patient-tailored monoclonal antibody therapy has shown promise in treating moderate to severe atopic dermatitis. . Patients who participated in a clinical trial of rocatinlimab showed positive results while taking the drug and up to 20 weeks after stopping therapy, Mount Sinai researchers have reported in The Lancet. .

Dermatology 52

Dermatology Clinical Trials Clinical Trials Antibody 52

pharmaphorum

SEPTEMBER 29, 2022

Sanofi and Regeneron have claimed the first approval in the US for a drug for prurigo nodularis, after the FDA gave a green light to Dupixent as a treatment for adults with the rare skin disease following a priority review. The post FDA clears Dupixent as first drug for rare skin disorder appeared first on.

Drugs 69

Drugs Immune Response Allergies Sales 69

Drug Discovery World

FEBRUARY 5, 2024

Williams discussed the advantages of the company’s ‘disease agnostic’ small molecule degraders, and its success so far in translating results from preclinical to clinical tests in dermatology, inflammation and oncology indications. Product launches More than 400 exhibitors are at the event this year, many of whom are launching new products.

Gene Therapy 65

Gene Therapy Life Science Production Dermatology 65

Pharmaceutical Technology

MAY 8, 2023

Adeno-associated virus vectors, alcohol dehydrogenase compositions, and antibody serum stabilisers are some of the accelerating innovation areas, where adoption has been steadily increasing. Among maturing innovation areas are anti-influenza antibody compositions and anti-interleukin-1, which are now well established in the industry.

Antibody 147

Antibody Vaccination Vaccine Dermatology 147

pharmaphorum

SEPTEMBER 30, 2022

Almirall has licensed an interleukin-2 (IL-2) drug from China’s Simcere Pharma, joining the ranks of companies looking at blocking the cytokine as a way to treat autoimmune diseases. It has also reached a deal with Ablexis to use its antibody development platform in therapeutics. Last year, Merck & Co paid $1.85

Licensing 52

Licensing Licensing Dermatology Drugs 52

pharmaphorum

JUNE 2, 2021

Amgen has made a play in a hot area of immunology R&D, paying $400 million upfront to claim rights to an OX40-targeting drug from Kyowa Kirin that is ready for phase 3 testing for atopic dermatitis or eczema. . Kyowa will co-promote the drug in the US if approved, with opt-in rights in some other countries as well.

Drugs 52

Drugs Licensing Licensing Sales 52

pharmaphorum

MAY 25, 2022

Roivant group company Dermavant has made the transition to a commercial-stage company after getting FDA approval for Vtama, a drug for psoriasis that it claims could be a game-changer in the treatment of the skin disorder. The post Dermavant claims its first approval as FDA clears psoriasis drug appeared first on.

Drugs 52

Drugs FDA Approval Licensing Licensing 52

pharmaphorum

DECEMBER 29, 2021

Sanofi and Regeneron have another challenger to their big-selling drug Dupixent for atopic dermatitis, now that the FDA has approved Leo Pharma’s rival antibody tralokinumab. That was enough to secure approval although it remains to be seen how well it will fare commercially against Sanofi and Regeneron’s drug.

Sales 110

Sales Dermatology Marketing Allergies 110

XTalks

SEPTEMBER 22, 2022

On September 1, 2022, Boehringer Ingelheim Pharmaceuticals announced in a press release that the US Food and Drug Administration (FDA) approved Spevigo (spesolimab-sbzo) intravenous injections for GPP flares in adults. Waldman Department of Dermatology. Spevigo is the first approved treatment option for GPP in adults.

FDA Approval 52

FDA Approval Clinical Trials Clinical Trials Dermatology 52

pharmaphorum

MAY 31, 2022

Sanofi and Regeneron should hear from the FDA in the autumn whether it will approve their blockbuster immunology drug Dupixent as a therapy for rare skin disease prurigo nodularis (PN). The review is based on a pair of phase 3 trials of Dupixent in PN patients whose symptoms were inadequately controlled with current drugs.

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Sales Drugs Antibody Regulation 115

The Pharma Data

DECEMBER 30, 2020

billion acquisition of immuno-oncology company Forty Seven and its lead asset, magrolimab, a monoclonal antibody in the clinic for several cancers, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL). It began in May with the $4.9 Magrolimab targets CD47.

Antibody 52

Antibody Allergies Branding Dermatology 52

Drug Discovery World

SEPTEMBER 16, 2022

Sponsored by Regeneron and Sanofi, the study of dupilumab in poorly controlled eczema is the first large-scale randomised double-blind trial of a monoclonal antibody for any skin disease in patients aged six months to six years. These pivotal trial results strongly support the global approval of dupilumab in infants and children with eczema.

Antibody 52

Antibody Licensing Licensing Trials 52

The Pharma Data

JANUARY 12, 2021

Virology, Respiratory, Dermatology, Allergy, & Rheumatology) in early & late stage Clinical Development and in Medical Affairs, with a strong track record for Developing and Accelerating Phase I–IV programs. Foralumab is the only fully human anti-CD3 monoclonal antibody (mAb) in clinical development in the world.

Life Science 52

Life Science Antibody In-Vivo In-Vitro 52

The Pharma Data

MAY 15, 2023

Food and Drug Administration (FDA) approval of Dupixent in September 2022 and the European Medicines Agency approval of Dupixent in December 2022. Safety results through 24 weeks were generally consistent with the known safety profile of Dupixent in its approved dermatology indication. Gil Yosipovitch, M.D.

Medicine 40

Medicine Trials Dermatology FDA Approval 40

The Pharma Data

AUGUST 16, 2021

Lebrikizumab is a novel monoclonal antibody (mAb) that binds soluble IL-13 with high affinity, has high bioavailability, a long half-life and blocks IL-13 signaling. associate professor of dermatology at George Washington University School of Medicine and Health Sciences in Washington, DC, and a principal investigator of the ADvocate 2 trial.

Dermatology 40

Dermatology Trials Bioavailability Medicine 40

Drug Discovery World

FEBRUARY 19, 2024

You can listen below, or find The Drug Discovery World Podcast on Spotify , Google Play and Apple Podcasts. The post New DDW Highlights podcast: 19 February 2024 appeared first on Drug Discovery World (DDW).

Drugs 52

Drugs Dermatology Antibody 52

Roots Analysis

MARCH 3, 2022

Since the approval of Soliris® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. Currently, nine complement therapeutics are commercially available, while around 190 molecules are under development for various disease indications. Next Generation Complement Therapeutics. Web: [link].

Drug Delivery Systems 52

Drug Delivery Systems Marketing Immune Response Dermatology 52

pharmaphorum

OCTOBER 22, 2021

Sanofi and Regeneron’s Dupixent has become the first biologic drug to show activity in prurigo nodularis (PN), raising the hope of a new treatment option for the rare and highly debilitating skin disease. PN is among a clutch of additional indications that could account for upwards of $2 billion of that total.

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Trials Sales Antibody Drugs 105

pharmaphorum

APRIL 26, 2021

UK biotech Avillion has reported positive mid-stage results with chronic psoriasis drug sonelokimab, which it is developing with Merck KGaA as an alternative to drugs like Novartis’ Cosentyx. . The drug is a nanobody, a molecule around one-tenth the size of a regular antibody derived from camelid species such as the llama.

Antibody 52

Antibody Drugs Marketing Licensing 52

pharmaphorum

AUGUST 16, 2021

billion to take control of lebrikizumab’s developer Dermira last year after the antibody showed promising results in phase 2b trials, and has been waiting for the results of the phase 3 trials to see if that was a good move. Lilly shelled out $1.1

Antibody 52

Antibody Trials Marketing Drugs 52

Drug Discovery World

DECEMBER 19, 2022

You can listen below, or find The Drug Discovery World Podcast on Spotify , Google Play and Apple Podcasts. . The post Listen now: Last episode of DDW Highlights for 2022 appeared first on Drug Discovery World (DDW).

Genetics 52

Genetics Drugs Development Dermatology 52

The Pharma Data

MARCH 23, 2022

The only large-scale prospective study in dermatology designed to generate key disease insights among Black, Hispanic, Asian, Indigenous and other people of color Study reinforces Janssen’s commitments to inclusive clinical research and addressing health inequities. 11 TREMFYA is approved in the U.S.,

Dermatology 52

Dermatology Clinical Research Research Medicine 52

pharmaphorum

AUGUST 24, 2021

UCB has been bringing up the rear in the IL-17 inhibitor category with bimekizumab, but now has EU approval for the drug and thinks it can mount a stiff challenge to the leaders, including Novartis’ big-selling Cosentyx. It says there is evidence to suggest that IL-17F is also a key contributor chronic tissue inflammation.

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Sales Marketing Drugs Antibody 52

pharmaphorum

APRIL 28, 2021

.” Along with Cosentyx and Taltz, the psoriasis market is already served by TNF inhibitors – including lower-cost biosimilars – as well as Bausch Health’s IL-17 drug Siliq (brodalumab), and three recently-launched IL-23 inhibitors from Johnson & Johnson (Tremfya), AbbVie (Skyrizi), and Sun Pharma (Ilumya).

Marketing 52

Marketing Trials Drugs Antibody 52

The Pharma Data

AUGUST 17, 2021

About JEMPERLI (dostarlimab-gxly) JEMPERLI is a programmed death receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2. The collaboration has resulted in three monospecific antibody therapies that have progressed into the clinic. Immune-Mediated Pneumonitis.

FDA Approval 52

FDA Approval Antibody DNA Hormones 52

The Pharma Data

APRIL 13, 2022

“I’m pleased that TAKHZYRO has met these key objectives and I look forward to Takeda sharing further insights with the HAE community in the near future,” said Dr. Marcus Maurer, Professor of Dermatology and Allergy Charité – Universitätsmedizin Berlin, Germany and principal investigator of SHP643-301.

Dermatology 52

Dermatology Allergies Genetics Antibody 52

The Pharma Data

MARCH 28, 2022

The focus of the event is on Dupixent ® (dupilumab), a key growth driver, and Sanofi’s rapidly advancing pipeline, highlighting dermatological, respiratory and gastrointestinal diseases as priority therapeutic areas. Sanofi has raised the Dupixent sales peak ambition to more than €13 billion.

Medicine 52

Medicine Sales Clinical Development Development 52

The Pharma Data

JUNE 7, 2022

1-2 Lebrikizumab is a novel, monoclonal antibody (mAb) that binds to the interleukin-13 (IL-13) protein with high affinity to specifically prevent the formation of IL-13R?1/IL-4R? Food and Drug Administration (FDA) for lebrikizumab in AD in the second half of 2022, followed by submissions to other regulatory agencies around the world.

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Trials Clinical Trials Clinical Trials Medicine 40

The Pharma Data

MARCH 15, 2022

The US Food and Drug Administration (FDA) has issued a complete response letter (CRL) regarding the supplemental Biologics License Application (sBLA) for Fasenra (benralizumab) for patients with inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP). 2 The trial is expected to read out in the second half of 2023.

Trials 52

Trials Medicine Licensing Licensing 52

The Pharma Data

JULY 11, 2021

Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin in Berlin, Germany. TAKHZYRO is a fully human monoclonal antibody that specifically binds and decreases plasma kallikrein activity. No dedicated drug-drug interaction studies have been conducted. All antibody titres were low.

Allergies 52

Allergies Antibody Recombinant DNA Technology Production 52

pharmaphorum

AUGUST 2, 2021

The IL-17 inhibitor is the first to go through a new process aimed at accelerating appraisals for drugs deemed to be low-risk, which is being piloted by NICE to help clear a work programme that has been held up by the COVID-19 pandemic. Nearly 18,000 people will be eligible for the treatment if approved, said the agency.

Marketing 52

Marketing Medicine Production Sales 52