Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Kielczewska will present: ‘Discovery of antibody-based therapeutics to challenging targets: Platform considerations’.

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Pharmaceutical Technology

FEBRUARY 1, 2023

Since the FDA approved AstraZeneca’s monoclonal antibody therapy Synagis (palivizumab) 25 years ago, drug development successes for RSV have been few and far between. In 2013, this changed when an NIH lab reported the structure of the RSV protein, leading to the exploration of the RSV structure in ways that were not previously possible.

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The Pharma Data

OCTOBER 27, 2020

27, 2020 — Testing of Eli Lilly’s antibody drug for hospitalized COVID-19 patients has been halted because the treatment doesn’t help them recover from their infection. A similar, two-antibody cocktail from Regeneron Pharmaceuticals Inc. Doctors say this reflects India’s younger and leaner population.

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The Pharma Data

NOVEMBER 10, 2020

10, 2020 — Eli Lilly’s experimental antibody treatment for COVID-19 was given emergency approval by the U.S. Employing a single powerful antibody that is believed to keep the infection in check, the treatment is similar to one that President Trump received when he was diagnosed with COVID-19. TUESDAY, Nov.

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Drug Discovery World

NOVEMBER 27, 2023

As the significance of large molecules continues to broaden across diverse modalities, emphasis on bispecific and multispecific antibodies to treat various disorders such as rheumatologic diseases, cancer, diabetes, anaemia, and infectious diseases becomes paramount. Biotechnol Bioeng 2012;118:2326. Budge JD, Knight TJ, Povey J, et al.

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Drug Discovery World

MAY 29, 2024

He says: “If you compare that with what’s happening within the monoclonal antibody space, for instance, everybody’s got standardised processes with standardised equipment. So yes, you’ve got protein, but it’s not going to transfect or infect.” That’s not the case in CGT.”

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The Pharma Data

NOVEMBER 9, 2020

Food and Drug Administration (FDA) today granted Emergency Use Authorization (EUA) for Eli Lilly and Company’s (NYSE: LLY) investigational neutralizing antibody bamlanivimab (LY-CoV555) 700 mg. INDIANAPOLIS, Nov. 9, 2020 /PRNewswire/ — The U.S. Ricks, Lilly’s chairman and CEO.

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The Pharma Data

JANUARY 26, 2021

. “These exciting results, which replicate positive Phase 2 data in a much larger set of patients, add valuable clinical evidence about the role neutralizing antibodies can play in fighting this pandemic. Lilly’s chief scientific officer and president of Lilly Research Laboratories. have reached record highs.

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The Pharma Data

APRIL 29, 2022

SK bioscience and GSK announced submission of a biologics license application for SKYCovione™ a recombinant protein-based COVID-19 vaccine candidate adjuvanted with GSK’s pandemic adjuvant, to the Korean Ministry of Food and Drug Safety (KMFDS) following positive Phase III clinical data.

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XTalks

JUNE 30, 2023

Hemophilia A is a rare genetic bleeding disorder that is caused by a mutation in the gene that encodes the key blood clotting protein factor VIII (FVIII). Severe hemophilia A is usually treated with FVIII replacement therapy or an antibody-based drug to improve the ability of blood to clot and reduce the likelihood of bleeding.

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Delveinsight

OCTOBER 1, 2021

This disease is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction. This medication is administered by injection under the skin or slowly into a vein as directed by the doctor.

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pharmaphorum

SEPTEMBER 7, 2020

Preliminary results published in The Lancet are from a non-randomised phase 1/2 trial of 76 people aged 18-60, which found an antibody response within 21 days and no serious adverse events after 42 days. All participants in the phase 2 trials (40 participants) produced antibodies against the SARS-CoV-2 spike protein.

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The Pharma Data

NOVEMBER 4, 2020

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. Your doctor will decide if you need additional vaccination. About ULTOMIRIS ®.

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pharmaphorum

DECEMBER 21, 2020

As it’s just a messenger molecule, it does not affect the body’s own genetic code when it is injected as a vaccine – but what it does do is instruct cells to code for copies of a certain protein. In this case that is the “spike” protein seen on the surface of the coronavirus that it uses to invade host cells.

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Drug Discovery World

APRIL 21, 2023

Atrandi Biosciences’ novel technology platform enables researchers to gain insights into the biology of single cells, offering immediate applications in single-cell sequencing, drug and antibody discovery, functional metagenomics, microbial analysis, directed evolution, and synthetic biology. It will be led by Björn C.

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Advarra

MARCH 10, 2023

Red blood cells contain hemoglobin, a protein that carries oxygen. A visit to a podiatrist and family doctor yielded less than satisfactory diagnoses. One surgery later, Moss spoke with a second doctor who immediately identified it as a sickle cell ulcer, and it would’ve gone away on its own.

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The Pharma Data

JUNE 30, 2021

For their remarkable scientific contributions, doctoral student Julia Klaus, Zurich University VetSuisse Faculty, and Dr Yasmin Parr from the MRC-University of Glasgow, Centre for Virus Research, have received the 2021 ABCD Young Scientist Award.

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The Pharma Data

DECEMBER 31, 2020

Doctors on the pandemic’s front line say people shouldn’t panic, but should definitely adhere even more closely to proven infection control measures, like mask wearing and social distancing. These mRNA vaccines are engineered to induce the immune system to produce antibodies to multiple areas of the spike protein, he said.

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The Pharma Data

JANUARY 17, 2021

. The treatment is based on the Grifols immunoglobulin Gamunex®-C, and contains anti-SARS-COV-2 polyclonal antibodies from plasma donors who have recovered from COVID-19. BARCELONA, Spain , Jan. 18, 2021 /PRNewswire/ — Grifols (MCE: GRF, MCE: GRF.P, BARCELONA, Spain , Jan.

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The Pharma Data

JANUARY 17, 2021

Darzalex Faspro is the only CD38-directed antibody that has been approved for subcutaneous injection for multiple myeloma, and now AL amyloidosis. AL amyloidosis is a blood disorder associated with an abnormal protein that causes deterioration of vital organs, especially the heart, kidneys and liver.

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The Pharma Data

SEPTEMBER 8, 2021

Related Peptide Monoclonal Antibody Therapy Added to OnabotulinumtoxinA Treatment. Real-World Evidence for the Safety and Efficacy of CGRP Monoclonal Antibody Therapy Added to OnabotulinumtoxinA Treatment for Migraine Prevention in Adult Patients with Chronic Migraine. Tell your doctor if you have any breathing-related problems.

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The Pharma Data

JANUARY 21, 2021

Doctors need better tools to evaluate the status of COVID-19 patients as early as possible because many of the treatments—such as monoclonal antibodies—are in short supply, and we know that some patients will get better without intensive treatments,” said co-senior author Andrew E. The research was published in the journal JCI Insight.

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The Pharma Data

JANUARY 4, 2021

TIGIT and PD-L1 are proteins that play a role in suppression of the immune system. Tiragolumab is a monoclonal antibody designed to bind with TIGIT, a protein receptor on immune cells. Tecentriq is a monoclonal antibody designed to bind with a protein called PD-L1. Too much protein in the urine.

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The Pharma Data

OCTOBER 19, 2020

Diagnostics Update : To-date the FDA has authorized 282 individual EUAs, which include 220 molecular tests, 56 antibody tests and 6 antigen tests. . Researchers at Johns Hopkins Medicine identified a protein , known as factor D, that appears essential to the inflammatory process of SARS-CoV-2, the virus that causes COVID-19.

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Delveinsight

AUGUST 13, 2020

Gluten is a protein in wheat, barley, rye, and other grains and is what makes dough elastic and gives bread its chewy texture. Takeda is finally developing TAK-101 , a disease-modifying agent, and an extremely novel immune modifying biodegradable nanoparticle encapsulating gliadin proteins for the treatment of CD.

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The Pharma Data

DECEMBER 2, 2020

Lisa began her career as Assistant Professor at Washington University School of Medicine, following a post-doctoral cardiovascular fellowship at the University of Chicago. The Company is building a pipeline of inhibitory monoclonal antibodies (mAbs) and fusion proteins targeting the pathway via multiple angles.

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Drug Discovery World

OCTOBER 20, 2022

Immunohistochemistry is a valuable tool that provides detailed images of the spatial relationships between cells in tissues and proteins in cells, in their most native, non- denatured states. For imaging mass cytometry, heavy metal-conjugated antibodies are added simultaneously to a tissue section adhered to a slide. About the author.

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The Pharma Data

JANUARY 15, 2021

1] Darzalex Faspro® is the first and only FDA-approved treatment for patients with this blood cell disorder that is associated with the production of an abnormal protein, which leads to the deterioration of vital organs, most notably the heart, kidneys and liver.[2],[3] Approximately 4,500 people in the U.S.

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XTalks

SEPTEMBER 14, 2020

Moderna, for one, recently reported positive results in older adults between 56 and 71, as well as those 71 years of age and older, who reportedly mounted levels of neutralizing antibodies against the SARS-CoV-2 virus after two doses of its vaccine that were comparable to those seen in younger adults. Johnson & Johnson’s COVID-19 Vaccine.

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The Pharma Data

MARCH 16, 2021

Developed by Janssen, TREMFYA is the first approved fully human monoclonal antibody that selectively binds to the p19 subunit of IL-23 and inhibits its interaction with the IL-23 receptor. Call your doctor for medical advice about side effects. Change in total vdH-S score is defined by change of score from baseline.

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The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. VENCLEXTA ® /VENCLYXTO ® (venetoclax) is a first-in-class medicine that selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein. Call your doctor for medical advice about side effects.

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The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. Call your doctor for medical advice about side effects. VENCLXEXTA/VENCLYXTO targets the BCL-2 protein and works to help restore the process of apoptosis. Call your doctor for medical advice about side effects. .

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The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. Call your doctor for medical advice about side effects. BTK signaling is needed by specific cancer cells to multiply and spread. to help reduce your risk of losing too much fluid (dehydration) due to diarrhea.

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The Pharma Data

MAY 4, 2021

Biosimilars, which grew 79% operationally to $530 million, primarily driven by recent oncology monoclonal antibody biosimilar launches of Ruxience (rituximab), Zirabev (bevacizumab) and Trazimera (trastuzumab) globally, as well as continued growth from Retacrit (epoetin) in the U.S.; Hospital products, which grew 10% operationally to $2.3

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