pharmaphorum

FEBRUARY 10, 2022

CVS Health has said it will beef up its clinical trials operations, improving its ability to recruit patients from a broad demographic spectrum, via an agreement with digital health company Medable. The post CVS, Medable alliance aims to tackle diversity in clinical trials appeared first on.

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XTalks

NOVEMBER 7, 2022

These tumor-derived entities are used to derive genomic and proteomic data. Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management. Liquid Biopsy Use in Oncology Clinical Trials.

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Clinical Trials Clinical Trials Trials FDA Approval 98

Crucial Data Soutions

AUGUST 6, 2020

In this blog post, we recap the top three tips our panelists provided throughout the presentation to confront the hurdles in today’s clinical trial landscape and achieve efficient study execution. For a number of years, the clinical trials industry relied on case report forms (CRFs) and a select few non-CRF sources (i.e.,

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Clinical Trials Clinical Trials Trials Genome 72

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 1, 2022

As drug companies have embarked on an initiative to launch affordable medicines for rare diseases in India, experts have called for using pharmacogenetics to develop treatments and whole genome sequencing to identify etiologies.

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Development Genome Genomics Medicine 177

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 11, 2023

The drug regulator, in a drug alert issued, said that a batch of Typbar, manufactured by Bharat Biotech International Ltd in Genome Valley in Hyderabad, Telangana, failed […]

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Vaccination Vaccine Genome Genomics 129

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 15, 2023

Some of the medical advances with the technology are genomics and epigenetics, Big Data, AI and ML which are allowing molecular […] Technology adoptions like artificial intelligence and machine learning are bringing in major transformation in the way a primary physician will extend treatment protocols.

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Big Data Genome Genomics Clinical Trials 100

Drug Discovery World

FEBRUARY 12, 2024

We’re already seeing biotechs making breakthroughs with AI in this area, with more than 150 small molecule drugs discovered and 15 already in clinical trials. Kishen Chahwala, PhD, Business Development Manager, Enhanc3D Genomics “AI is transforming the way we fight cancer by unlocking the secrets of large and complex datasets.

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pharmaphorum

JANUARY 18, 2023

However, the Resilience Project’s scientists had used genomic data originally collected for other studies and, due to limitations in the original studies’ informed consent policies and a lack of infrastructure to recontact participants, none of the 13 individuals could be contacted with follow-up questions or requests.

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pharmaphorum

SEPTEMBER 16, 2022

Essentially, the collaboration brought together both “the right expertise and the right technology”, opening up myriad possibilities for targeting GPCRs within the human genome. It also bodes well for improving clinical trial success rates. A notable issue with clinical trials is the homogeneity of the patient database.

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Development Research Drugs Clinical Trials 135

WCG Clinical

NOVEMBER 17, 2023

This change expanded the definition of HGT research to include research using nucleic acids that are able to replicate, be transcribed, translated into protein, and/or integrate into the host genome. If implemented, these changes would broaden the definition of HGT to include new gene editing and genome-modified products.

Genome 52

Genome Genomics Gene Editing Genetic Engineering 52

pharmaphorum

APRIL 23, 2020

You can listen to our March webinar here: [link] Focus During the April instalment, our expert panel will discuss: •Assessing the pharmaceutical market impact of COVID-19 •The UK clinical trials on COVID-19: navigating uncharted waters •Genomics: research in the time of COVID-19 •Knowledge sharing: the COVID-19 experience from a US perspective •Getting (..)

Genome 40

Genome Genomics Life Science Clinical Trials 40

XTalks

MAY 20, 2022

Doctors and physicians rely on the results provided by a clinical scientist to make an accurate prognosis, diagnosis and assessment for a patient’s treatment plan. What is it Like to Work as a Clinical Scientist? A clinical scientist is often synonymous with: Clinical Research / Clinical Laboratory Scientist.

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Scientist Life Science Clinical Research Doctors 105

XTalks

APRIL 24, 2023

Melanie Blank, clinical team leader for General Medicine Branch 1 at the US Food and Drug Administration’s (FDA) Division of Clinical Evaluation and Pharmacology/Toxicology (DCEPT), the agency is seeing one or two new applications coming in every week for new gene therapies for different diseases. Reference: Chung DC, et al.

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Gene Therapy Gene Trials Clinical Trials 95

XTalks

NOVEMBER 19, 2021

Cardiac biomarkers can not only serve important roles in the diagnosis, management and prognosis of cardiac diseases, but they can also be significant tools in evaluating treatments in cardiovascular (CV) clinical trials. In CV clinical trials, cardiac biomarkers are most commonly included in efficacy and safety endpoints.

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Clinical Trials Clinical Trials Trials In-Vitro 98

pharmaphorum

SEPTEMBER 12, 2022

Alongside drugs and therapeutics, data collection and technology enhancements have redefined the traditional healthcare experience, especially within oncology, and genomic profiling has become a significant factor in allowing for personalised care. Tailored oncology. Navigating barriers to access.

Genome 105

Genome Genomics Clinical Trials Clinical Trials 105

pharmaphorum

NOVEMBER 9, 2020

In April, 73% of clinical trials were stopped, and, as of early October, more than 40% were still on hold. Aisling said we were “unlikely” to reach pre-COVID levels of non-SARS-CoV-2 clinical research before August 2021, even without the looming second wave. COVID-19 has transformed the way clinical trials are run.

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Clinical Trials Clinical Trials Clinical Research Research 75

pharmaphorum

MARCH 10, 2022

“The one silver lining of COVID was that it demonstrated what effective medical research can look like, and how quickly it can have a patient benefit,” she said, highlighting how quickly SARS-CoV-2 was sequenced, the results shared, and how genomic surveillance had helped nations respond to variants.

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Research Genome Genomics Clinical Trials 97

pharmaphorum

NOVEMBER 27, 2022

A group representing pharma companies selling precision therapies for cancer has called for a change to the way genomic testing is done in Scotland, to make sure patients get access to targeted drugs. The post Genomic testing ‘should be offered to all cancer patients in Scotland’ appeared first on. Why not lead?”

Genome 103

Genome Genomics Genetics Medicine 103

Advarra

NOVEMBER 29, 2022

The BGTC will act as a traffic light for these therapies, providing information on basic and clinical research, manufacturing, production, and regulatory requirements. The document includes recommendations on safety, manufacturing, clinical study design, and analytical comparability of CAR-T products.

Gene Therapy 52

Gene Therapy Gene Production Clinical Trials 52

The Pharma Data

JANUARY 17, 2021

The service is expected to become operational in 2021 and will be available for clinical research and clinical care — starting with private patients, followed by expansion into the public healthcare system over time. “We Guardant Health has achieved CE mark approval as well as U.S.

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Genome Genomics Clinical Trials Clinical Trials 40

The Pharma Data

MARCH 11, 2021

Lilly will present findings from a post-hoc safety analysis of the Phase 1/2 LIBRETTO-001 trial, the largest clinical trial in patients with RET -altered cancers. LY3484356, an oral SERD, is currently being studied in a Phase 1/2 clinical trial. Session Type: Clinical Trials Plenary Session.

Research 52

Research Clinical Trials Clinical Trials Trials 52

Drug Discovery World

APRIL 14, 2023

She is also a Professor of Pathology at the Johns Hopkins University School of Medicine, Co-director of the Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care, and Deputy Director of the Johns Hopkins Institute for Clinical and Translational Research.

Genetics 52

Genetics Research Medicine Clinical Research 52

pharmaphorum

FEBRUARY 10, 2022

These included computational and digital skills, the integration of clinical, industrial, and economic research, and genomic and phenotypic insights. People with the ability to integrate data across the patient pathway, in order to aid both research and treatment development, are, the report says, in particularly high demand.

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Life Science Genome Genomics Research 105

pharmaphorum

JULY 7, 2021

By making the UK a more attractive destination for commercial investment we can boost what our scientists right around the UK can achieve together with NHS staff in those areas – bringing direct benefits to patients for example through clinical trials. This can also benefit patients and the NHS.

Life Science 59

Life Science Manufacturing Genome Genomics 59

Drug Discovery World

DECEMBER 8, 2023

With human clinical trials with AI-designed drugs now ongoing, it’s only a matter of time until the FDA approves its first AI-designed drug. It is imperative for the industry to communicate the precise composition and attributes of these therapies to regulatory bodies.

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Gene Therapy Gene In-Vitro Development 65

pharmaphorum

DECEMBER 20, 2022

Through the use of genomic, proteomic, epigenetic, immunopeptidomic, and microscopy technologies, scientists are better able to examine cancer cells, molecules, and ecosystems at unprecedented resolution.

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Scientist Research Genetics Drugs 98

pharmaphorum

MAY 18, 2022

Genomics has unlocked entirely new insights to what exactly may cause certain neurological conditions. A lot more research is needed including large-scale clinical trials, which comes at a certain amount of investment and risk.”. The value of external science and strategic collaboration.

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Gene Therapy Gene Genetics Development 88

The Pharma Data

NOVEMBER 5, 2020

Deep Genomics – Toronto-based Deep Genomics appointed Amanda Kay to the newly-created role of chief business officer. Prior to joining Deep Genomics, Kay was senior vice president of Corporate Development and a member of the executive team at Synlogic, Inc. Additionally, the company also appointed Thomas E.

Genome 40

Genome Genomics Medicine Life Science 40

The Pharma Data

DECEMBER 15, 2020

As the world’s first PPAR pan agonist that completed two confirmatory phase III clinical trials, Chiglitazar Sodium has shown significant and long-lasting hypoglycemic effects in a series of clinical studies, as well as other comprehensive effects including significant insulin sensitization and blood lipid regulation.

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Insulin Drugs Production Clinical Trials 40

XTalks

DECEMBER 1, 2020

Fortunately, technological advances — such as those pioneered by Menarini Silicon Biosystems — have allowed researchers and healthcare practitioners to decipher these issues, drilling down to single-cell genomic levels to uncover variations that may account for reduced drug efficacy or biochemical resistance. billion in 2019.

Clinical Trials 96

Clinical Trials Clinical Trials Trials Clinical Research 96

Drug Discovery World

JULY 12, 2023

This paid-for advertorial by BC Platforms appeared in DDW Volume 24 – Issue 3, Summer 2023 The use of real-world data (RWD) is demonstrating significant potential to enhance rare and orphan disease clinical research and development. How can researchers gain access to rare and orphan disease patient data, including RWD?

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Research Genome Genomics Clinical Trials 52

XTalks

FEBRUARY 27, 2024

XTALKS WEBINAR: A Collaborative Approach to Advancing Access and Equity in Rare Disease Clinical Trials Live and On-Demand: Thursday, February 29, 2024 , at 11am EST (4pm GMT / UK) Register for this free webinar to join the discussion with clinical trial experts on a collaborative approach to patient-friendly trials in rare disease.

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Research Drugs Gene Therapy Clinical Trials 59

pharmaphorum

MAY 18, 2022

At the height of the COVID-19 pandemic, these capabilities were put to the test, being used to compare hospital caseloads to research activity in real-time and enabling COVID-19 clinical trials to rapidly recruit participants across the UK. It would be fantastic if we could shift that paradigm when we are talking about research.

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Research Clinical Research Trials Pharma Companies 81

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Partnerships and Establishing Research Cohorts. Genomic biomarker discovery helps drive the development of innovative new personalized therapies.

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Research Biobanking Drugs Genome 98

XTalks

DECEMBER 17, 2021

And in healthcare and health research, trends towards increased digitization continued, including remote monitoring in clinical trials, use of wearable technologies and AI-based approaches to data collection, management and analysis. The year 2021 was all about continuing innovations in the life sciences.

Life Science 98

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The Pharma Data

JANUARY 10, 2021

SH ) submitted its pivotal phase III clinical trial application (IND) of national class I innovative drug Chiauranib to NMPA, for the treatment of Small Cell Lung Cancer (SCLC) as a single agent for the patients after 2nd-line systemic chemotherapy and recurrence afterwards. SHENZHEN, China , Jan.

Clinical Trials 52

Clinical Trials Clinical Trials Drugs Trials 52

Pharmaceutical Technology

OCTOBER 26, 2022

Early gene therapy methods were proposed in the 1970s, and the first approved gene therapy clinical research in the US began in 1990. New doors were opened in the 2000s with the development of genome editing, such as CRISPR-Cas9, which introduces molecular tools to change existing DNA. Collaboration and integrated manufacturing.

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