Drug Discovery World

FEBRUARY 8, 2023

A diversity study has shown that clinical trials should use real world diseases epidemiology data, rather than US Census Bureau race and ethnicity data, to ensure enrolment reflects the populations affected by different diseases. It also showed that GSK trial enrolment for each condition differed by race and ethnicity.

Clinical Research 97

Clinical Research Research Clinical Trials Clinical Trials 97

AuroBlog - Aurous Healthcare Clinical Trials blog

DECEMBER 21, 2022

Scientists have found an extremely subtle twist in the genetics of aging cells, one that seems to make them increasingly less functional as time goes on.

Genetics 178

Genetics Gene Scientist Research 178

Cloudbyz

JUNE 26, 2023

Generative artificial intelligence (AI) techniques are increasingly being applied in clinical research to enhance various aspects of medical data analysis, diagnosis, treatment planning, and drug discovery. Clinical Trial Design and Optimization: Generative AI can aid in the design and optimization of clinical trials.

Clinical Research 76

Clinical Research Research Clinical Trials Clinical Trials 76

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 29, 2024

A unique genetic mutation in two siblings – that has never been seen in anyone else – has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for type 1 diabetes. The mutation is in the gene for a protein called programmed death-ligand 1 (PD-L1), and a […]

Gene 190

Gene Genetics Protein Research 190

Pharma Mirror

MAY 7, 2021

The leading Australian CRO for biotechs and Frost & Sullivan Asia-Pacific CRO Market Leadership Award winner, Avance Clinical, has expanded its gene technology clinical trial services to meet the increasing global demand predicted to reach $17.4 billion by 2023.

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Clinical Trials Clinical Trials Gene Marketing 130

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return.

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Genetic Disease Genetics Research Genome 95

ACRP blog

JUNE 7, 2023

If you hadn’t already noticed, the clinical research enterprise has well and truly entered the era of “big data,” artificial intelligence (AI), and machine learning. Undoubtedly, the expectations for precision medicine are high,” Olsen adds.

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Big Data Clinical Research Research Clinical Trials 59

XTalks

MARCH 20, 2024

When it comes to leadership in clinical trials today, what qualities are necessary to navigate the evolving landscape of clinical research effectively? Xtalks recently had the opportunity to discuss Enciso’s journey in the clinical research industry and her decision to join Regeneron.

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Clinical Trials Clinical Trials Trials Clinical Research 52

ACRP blog

APRIL 20, 2023

Social justice models can contribute to diversity, equity, and inclusion (DE&I) in clinical trials and across companies, helping to ensure a fair and equitable division of resources, access, and opportunities. Building trust is helped by having diverse site staffing and site infrastructures to engage with underserved populations.

Clinical Research 59

Clinical Research Research Clinical Trials Clinical Trials 59

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 17, 2024

Similar genetic changes in two different types of brain cells may contribute to cognitive impairment in schizophrenia and aging. US researchers examined gene expression in more than a million brain cells collected post-mortem from 191 donors.

Gene Expression 188

Gene Expression Gene Genetics Research 188

XTalks

DECEMBER 28, 2023

BillionToOne, a company specializing in molecular diagnostics, has partnered with Janssen Research & Development, LLC, a Johnson & Johnson division, to conduct the AZALEA Phase III clinical trial globally. The trial is set to occur across the US, the European Union (EU) and selected global locations.

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Trials Clinical Trials Clinical Trials Antibody 97

Pharmaceutical Technology

JUNE 15, 2023

But before pharmaceutical companies can go to market with a breakthrough drug, they need to ensure safety and efficacy through clinical trials. Pharma R&D teams are solving this problem by leveraging the power of artificial intelligence (AI) in clinical trials to save time and money.

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Clinical Trials Clinical Trials Trials Development 130

pharmaphorum

APRIL 26, 2022

Making sure clinical trials are diverse and representative of the populations they’re studying isn’t just the right thing to do to promote inclusivity and equity; it’s also just good science/clinical scientific practice. Potential barriers that exclude communities from clinical research.

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Clinical Trials Clinical Trials Trials Regulation 98

XTalks

FEBRUARY 21, 2024

Black participation in clinical trials, and the underrepresentation of minority groups in general in trials, remains low. It is therefore important to work towards increasing Black participation in clinical trials, which begins with understanding the barriers to participation and taking steps to address them.

Clinical Trials 59

Clinical Trials Clinical Trials Trials Life Science 59

Worldwide Clinical Trials

NOVEMBER 27, 2023

In trials, Casgevy was shown to help prevent episodes of debilitating pain, known as vaso-occlusive crises, that often plague patients affected by sickle cell disease. sickle cell disease community and the millions around the globe who suffer from this genetic illness.

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Gene Editing Gene Gene Therapy In-Vivo 184

XTalks

MAY 17, 2023

The Foundation for the National Institutes of Health (FNIH) announced this week that the Accelerating Medicines Partnership Bespoke Gene Therapy Consortium (AMP BGTC) has selected eight rare diseases for its clinical trial portfolio. Of the more than 10,000 rare diseases, more than 80 percent are caused by genetic defects.

Gene Therapy 98

Gene Therapy Clinical Trials Clinical Trials Gene 98

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 7, 2023

New research from ETH Zürich in Switzerland could see future wearable devices (with perhaps a few implants and a touch of genetic engineering) boost our health directly. Fitness trackers help you stay healthy by keeping count of your steps and monitoring your heart rate, driving you on to hit those cardio goals.

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Genetic Engineering Gene Engineer Genetics 207

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 25, 2023

Scientists from the US, UK, and Uruguay analyzed data from 378,932 people aged 40 to 69 to see how those who are genetically ‘programmed’ to nap regularly fared cognitively […]

Genetics 206

Genetics Scientist Clinical Trials Clinical Trials 206

Drug Discovery World

MAY 17, 2023

Leveraging historical trial databases has become commonplace in assessing the feasibility of trials in therapeutic areas with a large breadth of clinical development history. EHR data also has a key role to play in designing future clinical trials. EHR data also has a key role to play in designing future clinical trials.

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Clinical Trials Clinical Trials Medicine Trials 52

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 8, 2023

As DNA holds the genetic code controlling how our bodies grow and are maintained, that’s a serious problem that […] The artificial sweetener sucralose (marketed as Splenda) is widely used and found in products like diet soda and chewing gum.

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DNA Scientist Genetics Production 200

Drug Discovery World

JANUARY 23, 2024

Sano Genetics, a software company working to accelerate precision medicine research, has raised $11.4 Access and referrals for patients to join trials often depend on the hospital or location where they’re receiving treatment – which is why recruiting for clinical trials is one of the biggest challenges in research.

Medicine 52

Medicine Genetics Clinical Trials Clinical Trials 52

pharmaphorum

MARCH 31, 2022

UK startup Sano Genetics has raised $11 million in first-round financing to develop its go-between service, which aims to overcome one of the big challenges in clinical research by connecting patients with trial sponsors. The post Sano raises $11m for patient and trial matchmaking platform appeared first on.

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Trials Genetics DNA Clinical Trials 52

XTalks

DECEMBER 14, 2023

In an insightful interview with Xtalks , Cassadie Moravek, the Senior Director of Clinical Trial Portfolio and Program Management at the Pancreatic Cancer Action Network (PanCAN) , shares her perspective on the organization’s efforts in advancing pancreatic cancer research and patient care. Read on to learn more from Moravek.

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Clinical Trials Clinical Trials Trials Doctors 52

Roots Analysis

MARCH 14, 2023

Clinical trials are a fundamental requirement for evaluating the safety and efficacy of novel therapeutic interventions. Initiating a clinical trial is a complex and time-consuming process, involving suitable planning and execution.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Clinical Research 52

XTalks

APRIL 24, 2023

Approximately 72 percent of rare diseases are genetic, and around 70 percent of rare genetic diseases emerge in childhood. The webinar included operational strategies for these trials from Laura Omoboni, MS, Executive Director of Clinical Trial Management. Rare diseases can often be progressive, chronic and fatal.

Gene Therapy 95

Gene Therapy Gene Trials Clinical Trials 95

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 19, 2023

Genetic inheritance is a physical link that tethers our birth parents; one-half of two sets of chromosomes meshing together to form our own unique set of molecular instructions for life.

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Gene Genetics Clinical Trials Clinical Trials 145

Olympian Clinical Research

MARCH 3, 2020

There’s no doubt that research volunteers play a significant role in getting these vital solutions out on the market for the people in need. Sometimes people are afraid to enroll in a clinical trial out of fear, confusion, or misinformation. What is a clinical trial? Why should I participate in a clinical trial ?

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Clinical Trials Clinical Trials Trials Clinical Research 52

Cloudbyz

NOVEMBER 30, 2021

As a relatively young industry, it’s no wonder that the clinical trial industry tends to undergo rapid change. Decentralized Clinical Trials. Decentralized Clinical Trials (DCTs) are clinical trials that remove reliance on central research sites for clinical studies.

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Clinical Trials Clinical Trials Trials Clinical Research 52

Worldwide Clinical Trials

OCTOBER 24, 2023

Seeking relief at the genetic cause of disease Engaged discussion with the audience followed my joint presentation on this topic with Matthew Fuller, PhD, PMP, Executive Director of Gene Therapy Research at Ultragenyx. Roughly 80% of rare diseases are due to a known genetic driver.

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Gene Gene Editing Gene Therapy Clinical Trials 130

Olympian Clinical Research

APRIL 15, 2024

Triggers vary among individuals and may include genetic, environmental, and psychological factors. Some potential triggers include: Genetic Predisposition : There is evidence that genetics play a role in the development of the condition, as it often occurs in people with a family history of autoimmune disorders.

Clinical Trials 52

Clinical Trials Clinical Trials Genetics Clinical Research 52

Drug Discovery World

APRIL 14, 2023

Clinical trials are, undoubtedly, an essential part of the drug development process, providing us with valuable information about the safety and efficacy of new treatments and therapies. of participants 2 Covid-19 vaccination trials. In fact, these demographics which make up 13.8% of the UK population represented only 5.7%

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Clinical Trials Clinical Trials Trials Drugs 52

Advarra

JUNE 20, 2023

Typical clinical development timelines for anticancer drugs average an estimated 6.7 Oncology research is unique in many ways, including the challenges researchers face. Innovation Organizations conducting oncology clinical trials face challenges distinct from the rest of the research community.

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Trials Clinical Trials Clinical Trials FDA Approval 52

Imperical Blog

MAY 20, 2020

Professionally, especially in the world of clinical research, the opposite is happening. We no longer have any option than to embrace technology and other unconditional approaches to decentralize clinical research away from the study site. Gene counselors and genetic testing. and Europe. Expanded-purpose wearables.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Genetics 52

XTalks

MARCH 2, 2022

The editorial team discussed the encouraging growth seen in recent years in rare disease clinical research in the life science industries, providing hope for improved diagnosis, care and treatments for patients with rare diseases. In the US, Black people only constitute five percent of all clinical trial participants.

Life Science 52

Life Science Clinical Trials Clinical Trials Trials 52

ACRP blog

APRIL 24, 2023

Courtney Burnett’s personal story, a brief history, and endless gratitude For patients and physicians alike, clinical research provides hope that ongoing innovation will offer new options to treat and even cure challenging illnesses. points out that modern healthcare and evidence-based medicine would not exist without clinical trials.

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Clinical Trials Clinical Trials Trials Medicine 98

XTalks

MARCH 27, 2024

Dhiman has 24 years of clinical research experience in the immunogenetics of vaccines and infectious disease diagnostics. She did her clinical microbiology fellowship at Mayo Clinic in Rochester, Minnesota. Beyond infrastructure, the value of the clinical team determines the success of a clinical trial.

Manufacturing 108

Manufacturing Clinical Trials Clinical Trials In-Vitro 108

Olympian Clinical Research

NOVEMBER 30, 2023

The exact cause of vitiligo is still under investigation, with factors like genetics , autoimmune responses, and environmental triggers all playing potential roles. Participate in Pioneering Research We invite individuals affected by vitiligo to participate in our ongoing clinical trials.

Clinical Research 52

Clinical Research Clinical Trials Clinical Trials Immune Response 52