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Women in Science Who Have Paved the Way Forward in Genetics

XTalks

This has ushered in a new era of genomics that is fostering rapid, detailed and personalized insights into human genetics. Xtalks is celebrating the International Day of Women and Girls in Science with a special overview of notable female scientists who have made revolutionary contributions to the field of genetics. Rosalind Franklin.

Genetics 119
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Nucleome raises £37.5m to shine light on ‘dark genome’

pharmaphorum

Oxford-based Nucleome – which is developing an atlas of the dark genome and is focusing initially on finding drugs for autoimmune diseases – notes that the region contains 90% of disease-associated genetic changes, including autoimmune disorders like multiple sclerosis, lupus, and rheumatoid arthritis.

Genome 59
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Delivering on the promise of gene editing

Drug Discovery World

Gene editing tools such as zinc finger nucleases, transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeat (CRISPR) nucleases have been heralded for their enormous potential to treat diseases and genetic disorders. Likewise, Lessard et al.

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Why a recent advancement is a giant leap for human genomics

Drug Discovery World

This technical tour de force will have far reaching implications for our understanding of the human genome and for practical use of this knowledge in clinical medicine. Completion of the human genome was made possible by LRS technology and will inspire a global change in use and development of this technology.

Genome 52
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Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. The libraries contain only the sequences that occur in the human repertoire, rather than randomly generated sequences,” adds Dr Leproust. .

DNA 98
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My Hemochromatosis cb vsl | Blue Heron Health News

The Pharma Data

All too often, it is lifestyle factors – the things we do day to day – that determines whether a particular gene switches on to create actual illness. The scientific study of how to undo genetic illnesses – like HCT – is called epigenetics. It’s because certain genes act one way on some people… and another way on other people.

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Tezepelumab NAVIGATOR Phase 3 Trial Met Primary Endpoint Of A Statistically Significant And Clinically Meaningful Reduction In Exacerbations In A Broad Population Of Patients With Severe Asthma

The Pharma Data

9, 2020 /PRNewswire/ — Amgen (NASDAQ:AMGN) and AstraZeneca today announced positive topline results from the Phase 3 NAVIGATOR trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations compared to placebo in patients with severe asthma. THOUSAND OAKS, Calif. ,

Trials 52