Drug Discovery World

MARCH 26, 2024

We were there to present the latest findings from our research. METTL1 inhibition leads to reduced tRNA methylation and stability of a subgroup of tRNAs and in several cancer cell lines impairs cell proliferation and cell cycle progression, accompanied by reduced expression of cell cycle regulators.

RNA 64

RNA In-Vivo In-Vitro DNA 64

Drug Discovery World

MAY 17, 2024

Deepika Khedekar , Associate Centralized Clinical Trial Lead at IQVIA Inc, looks at the challenges of utilising artificial intelligence (AI) in oncology clinical research. MIT research 4 tells us a hard truth: about 95% of these trials fall short, leaving behind a trail of broken hopes for cancer patients each year.

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Trials Clinical Trials Clinical Trials Protein 59

XTalks

MAY 31, 2023

The research demonstrates that excessive intake of table salt can elevate several indicators for dementia and Alzheimer’s disease. The research team utilized a mouse model, feeding the mice a high sodium solution (two percent sodium chloride) in their drinking water for 12 weeks, and noted their blood pressure throughout the study.

Protein 111

Protein Hormones Containment Branding 111

pharmaphorum

SEPTEMBER 14, 2020

AstraZeneca has resumed UK trials for its coronavirus vaccine, after the country’s medicines regulator gave the all-clear following a safety scare. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.

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Vaccination Vaccine Trials Protein 102

XTalks

JUNE 28, 2023

Gene therapies for Duchenne muscular dystrophy (DMD) have been an area of intense research and Sarepta’s Elevidys is now the first one to be approved by the US Food and Drug Administration (FDA). DMD is caused by the absence of dystrophin, a protein that helps maintain the integrity of muscle cells.

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Gene Therapy Gene Protein FDA Approval 98

XTalks

SEPTEMBER 28, 2023

This is because the US has more lenient food ingredient regulations, potentially exposing consumers to carcinogens and harmful chemicals. Most research, however, suggests that the amount of titanium dioxide ingested from food is minimal, posing little to no risk to human health.

Hormones 52

Hormones Containment Production Cosmetics 52

XTalks

MAY 13, 2022

A container closure system consists of all the packaging components that contain and protect a pharmaceutical product. Container Closure Systems. A container closure system protects the product from environmental conditions, safeguarding a product’s purity, strength, safety and efficacy.

Packaging 98

Packaging Packaging Containment Production 98

Pfizer

AUGUST 11, 2022

The information contained in this statement is as of August 11, 2022. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. . Disclosure Notice . 07.27.2022. COVID-19, Vaccines. 07.19.2022. 1 Adapted Bivalent Vaccine Candidate.

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Containment Vaccination Vaccine Development 49

Pharmaceutical Technology

DECEMBER 9, 2022

M&A – Commended PRODUCT LAUNCHES – Commended RESEARCH AND DEVELOPMENT – Commende d. Solvias is a Swiss-based pharmaceutical company focused on contract research, development and manufacturing. Pharmaceutical Technology Excellence Rankings – The Verdict.

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Development Production Manufacturing Vaccination 130

Drug Discovery World

NOVEMBER 14, 2022

Find out more: New human beta cell model enables discoveries in diabetes research . Based on research into adrenergic signaling by professor Tore Bengtsson at Stockholm University, ATR-258 is a small molecule therapy that works by selectively stimulating b2-adrenergic receptors to translocate GLUT4 to the cell membrane. .

Development 52

Development Gene Therapy Drugs Gene 52

XTalks

AUGUST 6, 2020

Epidiolex is the only FDA-approved formulation that contains CBD derived from the cannabis plant. CBD is the most abundant non-psychoactive cannabinoid compound found in the cannabis plant, making up about 40 percent of the plant’s extract, which contains over 100 different cannabinoid compounds.

FDA Approval 64

FDA Approval Protein Containment Genetic Disease 64

XTalks

APRIL 14, 2021

New research published in Science Advances has suggested that a natural cyan blue extracted from red cabbage could replace synthetic blue dyes in food. Food coloring is an essential part of the food and beverage industry; however, some research suggests that using synthetic dyes is not healthy for the consumer. 1, FD&C Blue No.

Regulation 94

Regulation Production Branding Cosmetics 94

The Pharma Data

OCTOBER 20, 2020

Patent and Trademark Office covering the use of Fatty Acid Binding Protein 5 (FABP5) inhibitors for the treatment of psychological disorders such as anxiety and post-traumatic stress disorder (PTSD). We look forward to continuing our research on FABP5 inhibitors in collaboration with Artelo.”. About Artelo Biosciences, Inc.

Protein 52

Protein Development Research Production 52

XTalks

JANUARY 12, 2022

The innovative food packaging is made from a type of corn protein called zein , starch and other naturally-derived biopolymers, which have been found to be sustainable replacements for PFAS and other plastic-coated paper. Additionally, the recycling rate of generated packaging and containers was only 53.9 So, how does it work?

Packaging 98

Packaging Packaging Scientist Bacteria 98

The Pharma Data

NOVEMBER 23, 2020

Under the partnership, Evotec will support Rappta’s programme of developing small molecule activators of the enzyme Protein Phosphatase 2A (“PP2A”), which downregulates multiple oncogenic signalling pathways responsible for driving cancer progression.

Development 40

Development Protein Regulation Containment 40

Drug Discovery World

AUGUST 21, 2023

Medications containing semaglutide such as Ozempic, licensed for diabetes, and Wegovy, for weight loss, are being studied to see if they can treat a range of different conditions, including addiction and dementia. In February 2022, a Danish study showed that the dementia rate was lower in patients randomised to GLP-1 RAs versus placebo.

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Clinical Trials Clinical Trials Trials Drugs 52

The Pharma Data

NOVEMBER 22, 2020

As the Pfizer and BioNTech COVID-19 vaccine goes to regulators and the Moderna vaccine approaches the end of its Phase III trials, AstraZeneca and the University of Oxford announced high-level results from an interim analysis of their COVID-19 vaccine, AZD1222. It contains the genetic materials of the spike protein.

Vaccination 52

Vaccination Vaccine Protein Genetics 52

Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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Manufacturing Hormones Contamination Containment 40

XTalks

JANUARY 28, 2022

Immunocore received Breakthrough Device Designation for Kimmtrak from the FDA in February 2021 followed by acceptance of its Biologics License Application (BLA) several months later by both US and European regulators. Related: Cancer Blood Test Developed by University of Oxford Researchers Can Detect Metastasis.

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FDA Approval Development Licensing Licensing 98

The Pharma Data

NOVEMBER 29, 2021

deputy director of the Office of Specialty Medicine in the FDA’s Center for Drug Evaluation and Research. “By Ovarian cancer often causes the body to overproduce a specific protein in cell membranes called a folate receptor. Cytalux may cause fetal harm when administered to a pregnant woman. Source link: [link].

FDA Approval 52

FDA Approval Drugs Cosmetics Protein 52

The Pharma Data

JANUARY 10, 2021

PLANEGG / MUNICH, GERMANY / ACCESSWIRE / January 11, 2021 / MorphoSys AG (FSE: MOR; Prime Standard Segment; MDAX & TecDAX; NASDAQ: MOR), a commercial-stage biopharmaceutical company and a leader in antibody, protein and peptide technologies, announced today that Jean-Paul Kress, M.D., Source link.

Containment 52

Containment Clinical Development Antibody Development 52

Roots Analysis

MARCH 8, 2023

Over time, various research studies have demonstrated the potential of exosomes ( membrane bound extracellular vesicles) in disease diagnosis, drug delivery and therapeutic applications. In addition, they are involved in regulating the expression of the targets that are linked to RNA as they can affect the expression of RNA.

RNA 52

RNA Drug Delivery DNA Development 52

Drug Discovery World

DECEMBER 29, 2023

Dr Sofia Ferreira, Director of Applications at Refeyn, discusses how various technologies can address the main challenges in membrane protein characterization, describing how novel technologies, such as mass photometry, can streamline and support analytical processes. Scientists use a multitude of membrane mimetics to overcome this issue.

Protein 52

Protein In-Vitro Research Containment 52

XTalks

NOVEMBER 10, 2023

The US Food and Drug Administration (FDA) has approved Takeda Pharmaceuticals’ Adzynma, the first recombinant protein product for prophylactic (preventive) or on‑demand enzyme replacement therapy (ERT) in adult and pediatric patients with congenital thrombotic thrombocytopenic purpura (cTTP), an ultra-rare blood clotting disorder.

FDA Approval 59

FDA Approval Gene Therapy Gene Clinical Trials 59

The Pharma Data

AUGUST 24, 2020

TGF-beta is a key cytokine that regulates various cell processes, including regulation of the immune system. Bristol Myers Squibb intends to initially focus research and development efforts of AVID200 in oncology and may consider advancing the asset in other disease areas, such as fibrosis. About Forbius.

Regulation 52

Regulation Engineer Development Protein 52

Pfizer

JANUARY 27, 2023

Pfizer Responds to Research Claims carterda Fri, 01/27/2023 - 19:48 Pfizer Responds to Research Claims Friday, January 27, 2023 - 08:00pm Share New York, N.Y., In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. and around the world.

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Research Vaccination Vaccine Drugs 112

The Pharma Data

OCTOBER 26, 2020

The agreement covers the gene therapy program targeting OTOF (OTOF-GT), the gene encoding the otoferlin protein. Sensorion is currently advancing two preclinical gene therapy programs conducted under a broad multi-program research partnership with the Genetics and Physiology of Hearing Unit at Institut Pasteur (Paris). Disclaimer.

Gene Therapy 52

Gene Therapy Gene Manufacturing Production 52

Delveinsight

OCTOBER 1, 2021

This disease is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction. Prograf is available for oral administration in the form of capsules (tacrolimus capsules USP) containing 0.5

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Marketing Antibody Drugs Sales 85

The Pharma Data

DECEMBER 30, 2020

AstraZeneca’s COVID-19 vaccine candidate AZD1222 is a viral vector-based, weakened version of adenovirus containing the genetic material of SARS-CoV-2 spike protein. The disparity is under investigation by the researchers. regulators would not be satisfied by that conclusion, Politico reported. “As

Vaccination 52

Vaccination Vaccine Trials Development 52

The Pharma Data

JANUARY 17, 2021

. The treatment is based on the Grifols immunoglobulin Gamunex®-C, and contains anti-SARS-COV-2 polyclonal antibodies from plasma donors who have recovered from COVID-19. It could also help contain outbreaks in places where the vaccination hasn’t begun or is still underway. BARCELONA, Spain , Jan.

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Clinical Trials Clinical Trials Trials Containment 52

XTalks

APRIL 26, 2021

After years of disappointing malaria vaccine trials, a malaria shot developed by researchers at the Jenner Institute at the University of Oxford has demonstrated an unprecedentedly high efficacy of 77 percent, and may be the magic bullet the world has been waiting for against the deadly disease.

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Vaccination Vaccine Immune Response Trials 105

Drug Discovery World

MARCH 7, 2023

Within this, Qatar is emerging as a country which is actively seeking to bolster its drug discovery and development sectors, through high levels of spending and investment into local research programmes. Qatar is a small country but faces many of the same healthcare problems that Western countries currently face.

Biobanking 52

Biobanking Drugs Genome Genomics 52

The Pharma Data

MARCH 5, 2021

At the Kundl site, Novartis is a pioneer and has decades of experience in pharmaceutical production of proteins and in more recent years of nucleic acids. This media update contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Disclaimer. Source link:[link].

Manufacturing 52

Manufacturing Vaccination Vaccine Production 52

The Pharma Data

OCTOBER 18, 2020

This study is the first to show that by increasing NAD + , NR helped protect telomeres which are important in addressing life-threatening telomere-related diseases, paving the way for future clinical research. The role of ChromaDex in this study was to provide NR through the ChromaDex External Research Program (CERP).

DNA 52

DNA Scientist Genetic Disease Research 52

The Pharma Data

JANUARY 25, 2021

The Advisory Board members that have been assembled by NervGen are world renowned Alzheimer’s disease researchers and are well positioned to provide the Company with the guidance it needs to maximize the chance of success in its studies.” ” “I am excited about the potential of NVG-291,” stated Dr. .

Clinical Development 40

Clinical Development Containment Development Research 40

The Pharma Data

NOVEMBER 4, 2020

The antibody is designed to bind to misfolded light chain protein and amyloid and shows binding to both kappa and lambda subtypes. This press release may contain “forward-looking statements,” including as such term is defined within Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, as amended.

Antibody 52

Antibody Containment Clinical Trials Clinical Trials 52

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate. These genetic switches assist transcription factors in binding to the promoter region.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40