Advarra
MARCH 31, 2023
The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. Gene Delivery Systems Genetic material, in the form of DNA or RNA, does not easily enter cells without the aid of a delivery system.
Drug Discovery World
JANUARY 19, 2023
This paid-for advertorial by Catalent appeared in DDW Volume 24 – Issue 1, Winter 2022/2023 One significant challenge in the manufacturing of cell and gene therapies is the production of high-quality plasmid DNA (pDNA). coli residual contaminants as well as product-related impurities. billion by 2030 (BioSpace, 11 August 2022).
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Drug Discovery World
FEBRUARY 28, 2023
mRNA technology helped us to vaccinate the world against SARS-CoV-2. At this stage, qPCR can be used to check for IVT efficiency, residual DNA contamination and adventitious agents such as microbes. Approximately 7,000 rare and ultra-rare diseases have been described, and yet, 90% have no approved therapeutic options 1.
Pharmaceutical Technology
FEBRUARY 3, 2023
With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more. The field of genomic medicine has reached a true turning point.
Drug Discovery World
APRIL 25, 2024
One of the most recent drivers of the cell line development market came from the Covid-19 pandemic, where research into vaccines skyrocketed and demand for cell lines was boosted as a result. HEK 293 cells on the other hand are used within viral vector productions which have wide-scale applications for vaccines and therapies.
XTalks
FEBRUARY 26, 2021
Having become a staple in research labs, HeLa cells have been in use for over 60 years, having been used in the development of the first live polio vaccine, drugs for treating herpes, Parkinson’s and leukemia, as well as in AIDS research and determining the long-term effects of radiation.
Drug Discovery World
MAY 11, 2023
Gene-based therapeutics and vaccines hold immense potential for more efficient and personalised treatment and prevention of complex diseases. In these cases, injection of the viral vector vaccines induced the production of antibodies recognising platelet factor 4 (PF4) found on patients’ platelets 1. coli, and Pichia cells.
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