pharmaphorum

MARCH 2, 2021

A combination of urgent need, unprecedented investments, and advances in genetic engineering has allowed what was once mere speculation to become not only our reality, but our future. Define clinically meaningful endpoints to successfully develop and safely deliver optimal doses for public use.

Genetics 52

Genetics Vaccination Vaccine Development 52

Pharmaceutical Technology

APRIL 26, 2023

This marks the first-ever designation for genetically modified gamma-delta T cell therapies. INB-400, an autologous, genetically engineered gamma-delta T cell therapy, is the company’s DeltEx chemotherapy-resistant autologous and allogeneic drug-resistant immunotherapy (DRI) technology.

Genetic Engineering 130

Genetic Engineering Drugs Genetics Engineer 130

Scienmag

JUNE 27, 2021

Credit: McMaster University HAMILTON, ON June 28, 2021 — Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

Engineer 61

Engineer Genetic Engineering Research Genetics 61

Drug Discovery World

OCTOBER 26, 2022

An international team of scientists have engineered protein banana lectin, or BanLec, to create a new version that can fight off a range of viruses without unwanted side effects. . But it’s also exciting to have created it by engineering a lectin molecule for the first time, by understanding and then targeting the structure.” .

Engineer 52

Engineer Genetic Engineering Scientist Protein 52

STAT News

JULY 11, 2022

Then it was almost instantly derailed by the death of an 18-year-old clinical trial volunteer named Jesse Gelsinger after he received a genetically engineered virus that had been developed to treat his rare liver condition. Read the rest…

Gene 111

Gene Gene Therapy Genetic Engineering Engineer 111

Drug Discovery World

MAY 21, 2024

Takara Bio has launched PrimeCap T7 RNA Polymerase (low dsRNA), a mutant T7 RNA polymerase suitable for mRNA therapeutic research and development. PrimeCap T7 RNA Polymerase is a mutant T7 RNA polymerase that has been genetically engineered to maintain high-performance RNA synthesis activity while reducing dsRNA production to less than 10%.

Production 59

Production RNA In-Vitro Genetic Engineering 59

Pharmaceutical Technology

MARCH 2, 2023

QN-023a is under clinical development by Hangzhou Qihan Biotechnology and currently in Phase I for Relapsed Acute Myeloid Leukemia. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Gene Editing 100

Gene Editing Genetic Engineering Engineer Clinical Trials 100

Medical Xpress

FEBRUARY 7, 2023

Patients usually receive FVIII that comes from donor blood or is produced using genetic engineering. However, about one third of those treated for severe hemophilia A develop antibodies (inhibitors) against FVIII.

Antibody 40

Antibody Genetic Engineering Development Engineer 40

BioPharma Reporter

SEPTEMBER 1, 2022

RoosterBio has entered into an exclusive distributor partnership with MBL Beijing Biotech: with RoosterBioâs expansion media, exosome collection media, bioreactor media and genetic engineering media to be sold and distributed by MBL Beijing and thus becoming readily accessible for the first time to MSC and exosome therapy developers in China.

Genetic Engineering 52

Genetic Engineering Manufacturing Engineer Genetics 52

Drug Discovery World

MAY 23, 2024

A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The researchers will use a genetically engineered herpes simplex virus type 1 to eliminate cancer cells. million of funding for this research project.

Genetic Engineering 52

Genetic Engineering Engineer Immune Response Vaccination 52

Scienmag

SEPTEMBER 8, 2020

Credit: Avalos Lab/Princeton University Researchers at Princeton University have created a new and improved way to more precisely control genetically engineered bacteria: by simply switching the lights on and off. Working in E.

Bacteria 56

Bacteria Genetic Engineering Engineer Genetics 56

Scienmag

MARCH 5, 2021

Researchers develop tunable system that harnesses the spread of cargo carried by gene drives Credit: Gerard Terradas, UC San Diego Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

Gene 52

Gene Scientist Genetic Engineering Genetics 52

Scienmag

DECEMBER 30, 2021

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient’s own immune cells to fight cancer. Now, scientists at Memorial Sloan Kettering Cancer Center’s Sloan Kettering Institute (SKI) have developed new CAR T cells that can do something their […].

Scientist 61

Scientist Genetic Engineering Engineer Genetics 61

Pharmaceutical Technology

FEBRUARY 15, 2023

To obtain human antibody responses within a mouse, mice are genetically engineered to be humanised for their Ig genes. KO-plus-transgenic humanisation involves generating genetically engineered (HumAb) mice by disrupting the endogenous mouse Ig genes and simultaneously introducing human Ig transgenes at a different and random location.

Gene Expression 130

Gene Expression Gene Genetic Engineering Antibody 130

XTalks

MARCH 21, 2024

In this episode of the Xtalks Food Podcast, Sydney talks about the new offerings, which were developed in collaboration with NotCo, a Chilean food-tech firm renowned for its AI-driven approach to crafting plant-based food solutions. The products contain ingredients like bamboo fiber, pea protein and mushrooms.

Genetic Engineering 98

Genetic Engineering Production Engineer Containment 98

Pharmaceutical Technology

AUGUST 17, 2022

Biopharmaceutical contract development and manufacturing organisation (CDMO) AGC Biologics has entered a strategic collaboration with RoosterBio to expedite the manufacturing of cell and exosome therapies. These capabilities comprise cell and exosome genetic engineering for expressing therapeutic targets.

Manufacturing 130

Manufacturing Gene Therapy Genetic Engineering Gene 130

Scienmag

APRIL 27, 2021

April 27, 2021 — University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease. First-of-its-kind advance holds promise for making new strides in research, treatments Irvine, Calif.,

Genetic Engineering 51

Genetic Engineering Genetics Engineer Development 51

XTalks

SEPTEMBER 27, 2023

Poseida is a clinical-stage biopharmaceutical firm that utilizes its unique non-viral gene engineering methods to develop innovative cell and gene therapies. Scientists working at Poseida Therapeutics.

Life Science 59

Life Science Genetic Engineering Engineer Gene Therapy 59

BioTech 365

JULY 26, 2021

ERS Genomics and Japan SLC Sign CRISPR/Cas9 License Agreement ERS Genomics and Japan SLC Sign CRISPR/Cas9 License Agreement Nobel prize winning CRISPR technology to be applied in development of genetically engineered animal models DUBLIN & SHIZUOKA, Japan–(BUSINESS WIRE)–ERS Genomics Limited, … Continue reading →

Genome 52

Genome Genomics Licensing Licensing 52

BioTech 365

MARCH 9, 2021

ERS Genomics and Setsuro Tech Sign CRISPR/Cas9 License Agreement ERS Genomics and Setsuro Tech Sign CRISPR/Cas9 License Agreement Nobel prize winning CRISPR technology to be applied in development of genetically engineered cell and animal models DUBLIN & TOKUSHIMA, Japan–(BUSINESS WIRE)–ERS … Continue reading →

Genome 52

Genome Genomics Licensing Licensing 52

Drug Discovery World

NOVEMBER 27, 2023

Across the biotherapeutics workflow The landscape of large molecule drug development has evolved significantly in recent decades. Technological innovations supporting discovery and development stages have concentrated on both upstream and downstream aspects of the workflow. This article is sponsored by Revvity.

Production 59

Production Engineer Gene Editing Gene 59

Cloudbyz

MARCH 5, 2024

In the intricate dance of drug discovery and development, two protagonists emerge as the cornerstones of modern medicine: biologics and small molecules. Development and Approval : Small Molecules: The pathway for development and regulatory approval is well-established, with clear guidelines for demonstrating safety and efficacy.

Development 78

Development Drugs Manufacturing Immune Response 78

pharmaphorum

DECEMBER 24, 2020

Tian’s lab builds on the work of scientists in the lab of Dr Loren Looger, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, Virginia, who used traditional genetic engineering techniques to convert the bacterial protein into a sensor of the neurotransmitter acetylcholine.

Development 77

Development Drugs Protein Genetic Engineering 77

XTalks

MARCH 18, 2024

By genetically editing microorganisms, scientists can now manipulate the metabolic pathways to produce foods with desirable properties. The precision fermentation study highlights how genetically engineered microorganisms can inhibit the growth of foodborne pathogens.

Genetic Engineering 52

Genetic Engineering Genetics Production Protein 52

Drug Discovery World

MARCH 7, 2024

Ginkgo is also working with Sensible Biotechnologies to develop an in vivo microbial mRNA manufacturing platform. Additionally, Ginkgo announced the successful completion of a manufacturing optimisation program with Biogen, focused on redefining the industry standard for manufacturing recombinant adeno-associated virus (AAV)-based vectors.

Gene Therapy 52

Gene Therapy RNA Engineer Gene 52

Pharmaceutical Technology

MAY 2, 2023

Chimeric antigen receptor T-cell (CAR-T) therapies are the only genetically modified cell therapies to have received regulatory approval, and they are currently utilised in relapsed/refractory settings. Cost-related unmet needs also scored highly.

Genetic Engineering 130

Genetic Engineering Antibody Clinical Trials Clinical Trials 130

Drug Discovery World

OCTOBER 4, 2022

With winter around the corner and cases once again on the rise, the last few weeks have seen some interesting developments related to Covid-19. Study reveals first genetic links in ME and Chronic Fatigue Syndrome . Researchers successfully exploit virus against advanced cancers .

Genetic Engineering 52

Genetic Engineering Genetics Engineer Drugs 52

Pharmaceutical Technology

JUNE 29, 2022

Developing best-in-class speciality enzymes. Novozymes has a long legacy of enzyme discovery and the ability to genetically engineer these speciality enzymes to be superior. After joint development, screening, and proof of concept, we purify the selected enzyme intermediate from Novozymes under cGMP conditions.

Drugs 295

Drugs Gene Therapy Manufacturing Production 295

Pharmaceutical Technology

MAY 8, 2023

Innovation S-curve for the pharmaceutical industry Zinc-finger nucleases is a key innovation area in pharmaceutical Zinc finger nucleases (ZFNs) are tools used in genetic engineering to cleave a chosen genomic sequence. ZFNs are also used to create a new generation of genetic disease models called isogenic human disease models.

Genetics 130

Genetics DNA Genetic Engineering Antibody 130

Roots Analysis

FEBRUARY 26, 2024

Whether it was a common cold or a genetic disease, prayers and sacrifices to the gods were the only hope of a remedy at such times. It is possible that the legend of Big Foot may be based on an unfortunate person suffering from elephantiasis or gigantism or some other genetic predisposition that would have rendered him abnormal.

Genetics 52

Genetics Medicine Genetic Engineering Genetic Disease 52

pharmaphorum

MAY 7, 2021

Gene editing firm CRISPR Therapeutics has announced a collaboration with US biotech Nkarta to develop natural killer (NK) cell therapies for cancer. Under the agreement, the companies will co-develop and co-market two CAR NK cell product candidates, one targeting the CD70 tumour antigen and the other target to be determined.

Gene Editing 52

Gene Editing Gene Genetic Engineering DNA 52

Drug Discovery World

MAY 7, 2024

However, despite these advancements in process optimisation and cell culture engineering, there remain areas that we need to improve. DC: Single-use technologies can have a dramatic impact in the drug discovery and development space by providing researchers a quick way to develop and screen different processes.

Antibody 59

Antibody Production Manufacturing Engineer 59

Pharmaceutical Technology

APRIL 5, 2023

This includes the first potential approval of a CRISPR-based gene therapy called exa-cel , which is developed by CRISPR Therapeutics and Vertex Pharmaceuticals. It’s a multifaceted issue and we perhaps need to go beyond our comfort zone in science and clinical development to understand what barriers patients are really facing.

Gene Therapy 147

Gene Therapy Gene Engineer Production 147

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today provided an update on its COVID-19 vaccine program. About NVX-CoV2373 NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of SARS-CoV-2, the virus that causes COVID-19 disease.

Clinical Development 52

Clinical Development Vaccination Vaccine Development 52

The Pharma Data

JANUARY 17, 2021

These models are engrafted with mouse tumors derived from the same strain background; this genetic similarity between tumor and host prevents the host from rejecting the tumor. Standard mice may develop anti-drug antibodies (ADA), which can neutralize the therapeutic or even trigger anaphylaxis.

Genetic Engineering 52

Genetic Engineering Genetics Engineer Immune Response 52

Drug Discovery World

NOVEMBER 17, 2022

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. However, the development of drugs takes decades which is too long for most biotech start- ups looking for fast-track drug development programs.

Bacteria 52

Bacteria Engineer Gene Genetics 52

pharmaphorum

SEPTEMBER 11, 2022

With the results in hand, the developers of the therapy – from the Netherlands Cancer Institute and Norway’s National Center for Cancer Immune Therapy – say they now intend to file for regulatory approvals in Europe before the end of the year, without a commercial partner “to try to ensure that it remains affordable.”

Trials 105

Trials Genetic Engineering Immune Response Engineer 105