pharmaphorum

JUNE 23, 2022

billion in potential milestones if the project advances through development and onto the market. Systemic administration of gene-editing drugs would avoid that process with an “off-the-shelf” option for a one-shot, potentially curative treatment for diseases associated with genetic mutations.

Gene Editing 97

Gene Editing In-Vivo Gene Sequencing Gene 97

pharmaphorum

MARCH 10, 2022

Scenic’s platform technology Cell-Seq is used to seek out genetic modifiers, defined as gene sequences that counteract the effect of another disease-associated gene. Scenic has developed a series of small-molecule drugs targeting QPTCL that block the expression of CD47 on cancer cells.

Genetics 98

Genetics Gene Sequencing Gene Clinical Trials 98

pharmaphorum

FEBRUARY 23, 2022

Interest in non-viral methods of delivering gene therapies has been growing in the face of current scrutiny of the safety of viral vectors like adeno-associated viruses (AAV), with a number of clinical programmes based on AAV under clinical holds imposed by the FDA.

Gene Therapy 105

Gene Therapy Gene Gene Sequencing Immune Response 105

pharmaphorum

OCTOBER 12, 2022

The neoantigens are selected based on gene sequencing of either a tumour biopsy or a blood sample, with an individual vaccine tailored to the patient manufactured and administered in a matter of weeks. As we all know, cancer vaccines have had a rough history. — Brad Loncar (@bradloncar) October 12, 2022.

Vaccination 105

Vaccination Vaccine Gene Sequencing RNA 105

Roots Analysis

FEBRUARY 21, 2022

Since the introduction of a gene sequencing method by Frederick Sanger in 1977, the field of genomic data collection and analysis has evolved significantly. Advancement in DNA sequencing technologies have resulted in noteworthy developments in various healthcare-related research fields, such as diagnostics and personalized medicine.

Marketing 52

Marketing Gene Sequencing DNA Genome 52

pharmaphorum

SEPTEMBER 14, 2022

SparingVision has raised €75 million in second-round funding that will be used to fund clinical trials of gene therapies for ocular diseases retinitis pigmentosa (RP) and dry age-related macular degeneration (AMD). The post SparingVision raises €75m for eye disease gene therapies appeared first on.

Gene Therapy 52

Gene Therapy Gene Gene Sequencing Gene Editing 52

Drug Discovery World

JULY 24, 2023

Post-expression isolation and purification are equally challenging: each unique process is costly and time-consuming to develop. Even with standardised methods, it typically takes months to achieve the first useful production of a biological drug.

Protein 52

Protein Manufacturing Gene Sequencing Production 52

Drug Discovery World

AUGUST 5, 2022

Evonetix is reimaging biology by developing a different approach to gene synthesis. With a team of around six engineers and six chemists, we spent the next 18 months developing the first chips. It is hoped that enzymatic synthesis will eventually enable greater accuracy over long sequence lengths. Why enzymatic synthesis?

DNA 52

DNA Engineer Gene Sequencing Gene 52

Drug Discovery World

SEPTEMBER 28, 2023

In the first article, you will hear from Andrievs Auseklis Auzin, Developer, Molport, Latvia. They are called “ Addressing the challenge of salt forms in drug discovery ”, “ A different approach: reimagining biology ”, and “ Women in Discovery: championing female leaders across drug discovery ”.

Drugs 52

Drugs Development Gene Sequencing DNA 52

pharmaphorum

APRIL 23, 2021

The alliance is based on Obsidian’s cytoDRIVE platform, which uses already approved small-molecule drugs alongside gene-editing medicines to control the expression of protein from a gene sequence. For example, adding a small-molecule might stabilise the medicine, allowing levels of the target protein to increase. .

Gene Editing 52

Gene Editing Genetics Drugs Gene 52

Drug Discovery World

DECEMBER 13, 2022

PacBio, developer of sequencing solutions, has announced its HiFi sequencing technology will be used in a pilot project for the Children’s Rare Disease Cohorts Initiative (CRDC) at Boston Children’s Hospital. . As causative variants are identified by CRDC researchers, results are returned to participants.

Genetics 52

Genetics Research Genome Genomics 52

pharmaphorum

OCTOBER 1, 2021

It has made Oxford Nanopore’s chief executive and cofounder Gordon Sanghera an on-paper fortune of £63 million, while another cofounder – chief business development officer Spike Willcocks – is now worth £30 million. Chief technology officer Clive Brown is also sitting on a £10 million stake.

Marketing 52

Marketing Business Development Genome Genomics 52

Roots Analysis

FEBRUARY 23, 2022

NGS has emerged as an evolutionary technology in modern biotechnology and healthcare research, enabling researchers to develop a better understanding of the cause and consequences of disease.

Genetics 52

Genetics DNA RNA Reagent 52

The Pharma Data

DECEMBER 28, 2020

Combining next generation sequencing (“NGS”) with its technology platform, the Company performs full-gene sequencing with deletion/duplication analysis in an array of panels that can be tailored to meet specific customer needs.

Genetics 52

Genetics Sales Gene Sequencing Marketing 52

XTalks

DECEMBER 14, 2022

Expanding upon the CRISPR-Cas9 gene editing system, researchers at MIT have designed a new technique called PASTE gene editing that can cut out defective genes and replace them with new genes in a safer and more efficient way. The MIT research team turned to a family of enzymes called integrases to meet their goal.

Gene Editing 98

Gene Editing DNA Gene Gene Sequencing 98

Drug Discovery World

FEBRUARY 5, 2024

Brian Gladsden, CEO, Mosaic Therapeutics “The industry has already made tremendous strides in targeted drug discovery in oncology, particularly as the industry moves further away from simply looking at tumour histology and relying more on cancer gene sequencing. In the past 10 years, immunotherapy trials have increased by 430%.

Research 116

Research Drug Delivery Systems Gene Sequencing Trials 116

pharmaphorum

AUGUST 21, 2020

Cambridge, UK-based Biofidelity has raised $12 million in first-round funding for its cancer diagnosis platform, which can detect mutations quicker than current approaches like gene sequencing. Both previously worked at Cambridge-based DNA sequencing specialist Base4 Innovation, where the technology was developed.

DNA 59

DNA Gene Sequencing Genetics FDA Approval 59

Drug Discovery World

MARCH 27, 2023

Genomics is driving a revolution in drug development and, in the long run, the state of public healthcare. Advances in sequencing are leading to scientific breakthroughs in preventative care, faster diagnoses, and proactive medical interventions. Jack Dix , Head of Healthcare Strategy and Consulting at Kainos, expands.

Genome 52

Genome Genomics Research Scientist 52

Roots Analysis

OCTOBER 16, 2023

DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence. These clones can be manipulated and mutated in vitro to alter the expression and function of a protein.

DNA 40

DNA Gene Protein In-Vitro 40

Scienmag

JULY 6, 2021

New method yields 10 times more data, reduces gene sequencing costs by one third Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells.

Gene Sequencing 75

Gene Sequencing Gene Development Research 75

Pharmaceutical Technology

MAY 26, 2023

As per the company, dbDNA is suitable for rapid, scalable manufacture of GMP DNA and can incorporate gene sequences of sizes ranging from 500bp to 20kb, which are typically unstable as pDNA. Last year, Odimma Therapeutics began utilising Touchlight’s platform to develop an immunotherapy cancer treatment.

DNA 130

DNA Manufacturing Gene Therapy Gene 130