XTalks

JULY 20, 2022

The production facility will be equipped to develop and manufacture plasmid DNA, nucleic acids, recombinant proteins and other therapeutics produced through methods involving microbial fermentation. Additionally, the site will be able to prepare and package 70 million fill and finish vaccine doses per year for commercial distribution.

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Vaccination Vaccine Manufacturing Life Science 105

XTalks

NOVEMBER 23, 2021

The expansion will include a new 30,000-square-foot building that will be able to produce 160 million doses of an mRNA vaccine per year, and up to 70 million prepared and packaged fill finish doses for commercial distribution annually. Additional production would be performed at other facilities for final packaging.

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Drug Discovery World

MAY 7, 2024

AEX chromatography has primarily been used in the polishing AEX step for the removal of impurities, such as DNA, HCP, etc., DC: Anion exchange (AEX) chromatographic approaches have always been a workhorse and stable of downstream operations, specifically in the mAb space, and are widely used to separate molecules based on their net charge.

Antibody 59

Antibody Production Manufacturing Engineer 59

Drug Discovery World

DECEMBER 14, 2023

Early operations focused on the discovery of green fluorescent protein (GFP), which played a very big role in early drug discovery research operations using cellular assays. But it comes with surface charge that will absorb proteins, DNA, and other things, unless you do something to treat that surface.

Drugs 52

Drugs Production Protein Genetic Analysis 52

Pfizer

AUGUST 15, 2022

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. 07.27.2022.

Drugs 99

Drugs Vaccination Vaccine In-Vitro 99

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

MAY 2, 2023

Steve Wowk , VP, Business Unit and General Management of Integrated DNA Technologies, shared with DDW the value of CRISPR-Cas9 in drug discovery. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. CRISPR libraries: Why do we need them?

Genome 52

Genome Genomics Gene DNA 52

XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. This involves testing and quality assurance of the DNA to make sure its integrity meets the strict vaccine requirements.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g., CRISPR diagnostics have successfully detected various pathogens, including RNA viruses (eg.

DNA 98

DNA Genome Genomics RNA 98

The Pharma Data

SEPTEMBER 1, 2020

About antigen testing An antigen test detects proteins which are structural or functional components of a pathogen and are thus very specific to that pathogen. SARS-CoV-2 Rapid Antigen Test package insert [2] European Centre for Disease Prevention and Control. Results are ready in only 15 minutes. References [1] Roche Diagnostics Ltd.

In-Vitro 52

In-Vitro Antibody Medicine Clinical Trials 52

STAT News

NOVEMBER 4, 2022

His goal was to find a treatment for his brother’s form of Duchenne muscular dystrophy, which is caused by a mutation that impeded his ability to make a crucial muscle protein called dystrophin. Many scientists hope that the approach proves to be a safer alternative to gene editing therapies that make permanent changes to DNA itself.

Gene Editing 105

Gene Editing Gene Gene Therapy Clinical Trials 105

Pfizer

JANUARY 27, 2023

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus.

Marketing 75

Marketing Production Drugs Licensing 75

Drug Discovery World

FEBRUARY 6, 2024

He discussed how microfluidics assisted synthesis and biologics testing, high throughput automated platforms, functional multiomics screening, artificial intelligence and machine learning have accelerated the development of protein and RNA-based therapeutics.

Life Science 65

Life Science Genome Genomics RNA 65

Drug Discovery World

DECEMBER 15, 2022

These platforms all induce double strand cuts in the chromosomal DNA that can be sealed by the cell, leading to a specific gene disruption, or resulting in a new target site for inserting DNA segments. Reduce/eliminate chromosomal disruptions caused by double-strand DNA breaks. In one example, Choi et al.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

The Pharma Data

AUGUST 3, 2021

The company confirmed the tirzepatide SURPASS program has met global regulatory submission requirements for evaluating cardiovascular risk and its intention to submit the registration package to regulatory authorities by the end of 2021. The company announced the acquisition of Protomer Technologies Inc.,

Antibody 52

Antibody Sales Development Production 52

Drug Discovery World

FEBRUARY 8, 2023

This helps ensure a high concentration of loaded capsids and adequate removal of impurities, such as host cell proteins and DNA. The threat of empty capsids Capsids are the protein shell that would usually enclose the genetic material of a virus. A crucial part of the AAV workflow is the purification of viral vectors.

Gene Therapy 52

Gene Therapy Gene Antibody Production 52

Pfizer

DECEMBER 13, 2022

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide.

Drugs 110

Drugs Licensing Licensing Production 110

The Pharma Data

OCTOBER 14, 2020

Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. The study led by Dr. Sergei Rudchenko, Ph.D., About TNX-1800.

Vaccination 40

Vaccination Vaccine Development Medicine 40

XTalks

AUGUST 2, 2023

2) Paxlovid (nirmatrelvir/ritonavir) Paxlovid is a dual-packaged oral medication for the treatment of COVID-19. Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease.

Sales 98

Sales Manufacturing FDA Approval Life Science 98

Pfizer

DECEMBER 20, 2022

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide.

Drugs 69

Drugs Licensing Licensing Containment 69

The Pharma Data

AUGUST 3, 2021

We are very pleased that our comprehensive nonclinical data package has addressed all issues identified related to DRG toxicity and the FDA has reached the decision that we may proceed with our OAV-101 IT clinical trial program and initiate the STEER trial,” said Shephard Mpofu, M.D., SVP, Chief Medical Officer, Novartis Gene Therapies.

Clinical Trials 52

Clinical Trials Clinical Trials Gene Therapy Trials 52

Pfizer

NOVEMBER 23, 2022

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide.

Licensing 40

Licensing Licensing Drugs Manufacturing 40

XTalks

SEPTEMBER 14, 2020

The company’s candidate vaccine, mRNA-1273, is a synthetic messenger RNA that encodes the stabilized SARS-CoV-2 spike protein. The University of Oxford/AstraZeneca partnership, in turn, is testing a viral-vectored coronavirus vaccine that again expresses the spike protein of SARS-CoV-2 virus. And stimulus packages continue.

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Vaccination Vaccine Antibody Life Science 92