Scienmag

JULY 1, 2022

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].

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BioTech 365

FEBRUARY 2, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: How does a cell regulate the repair of its damaged DNA? Human DNA can be modified or damaged in a variety of ways that can alter its sequence … Continue reading →

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Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

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BioTech 365

SEPTEMBER 21, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulator proteins or symphonies of genes: Statistical modeling points way toward unified theory for DNA folding.At more than 2 meters long, the human DNA molecule uses intricate … Continue reading →

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Bio Pharma Dive

MARCH 20, 2023

The DNA-sequencing company said the activist investor hasn’t offered any better solutions for satisfying regulators’ concerns about the acquisition.

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DNA Regulation 137

Bio Pharma Dive

APRIL 3, 2023

The San Diego-based DNA-sequencing company, which also faces a challenge from European antitrust regulators, said it will appeal the FTC’s order.

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Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. Many scientists are now discovering that this junk DNA plays an essential role in our biology and the epigenetic processes that respond to the environment to drive disease.

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Bio Pharma Dive

APRIL 4, 2023

While financier Carl Icahn and regulators want the DNA-sequencing company to divest liquid biopsy company Grail, Illumina’s board isn’t budging yet. Analysts say they may be waiting for the best moment.

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BioPharma Reporter

OCTOBER 5, 2023

Researchers from Chung-Ang University, Korea have developed a novel DNA biosensor which could result in early diagnosis of cervical cancer.

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BioPharma Reporter

SEPTEMBER 8, 2022

A collaboration between Touchlight and Lonza expands the Swiss CDMOâs end-to-end offering for mRNA manufacturing with an additional, differentiated source of DNA raw material, the UK biotechâs doggybone DNA (dbDNA).

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BioPharma Reporter

FEBRUARY 3, 2022

Polyplus, a provider of transfection reagents, has acquired e-Zyvec, a France-based provider of DNA design and production services for tailor-made DNA vectors to expand expertise in plasmid DNA vector engineering.

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Scienmag

JANUARY 22, 2021

coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].

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Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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Scienmag

JANUARY 28, 2022

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine. organizes the spool-like structures around which DNA […].

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BioTech 365

APRIL 5, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: DNA methylation from bacteria and microbiome using nanopore technology.Bacterial DNA methylation occurs in diverse sequence contexts and plays important functional roles in cellular defense and gene regulation.

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BioTech 365

JANUARY 22, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulating the ribosomal RNA production line.The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant … Continue reading →

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Scienmag

MAY 10, 2022

Regulating what kinds of cargo can pass through the borderlands formed by the cell’s two-layer membrane is essential […]. Just as countries import a vast array of consumer goods across national borders, so living cells are engaged in a lively import-export business.

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BioTech 365

JUNE 2, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulation of the genome affects its 3D structure.All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. … Continue reading →

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BioTech 365

FEBRUARY 4, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study uncovers structural features regulating mRNA processing.RNA is the central tenet of molecular biology, the stepping-stone between DNA and proteins. from Biotechnology News – Biology News [link].

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Medical Xpress

MARCH 24, 2023

A new research paper, titled "VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer," was published in Genes & Cancer on March 10, 2023.

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BioPharma Reporter

JULY 6, 2022

Touchlight has agreed to a non-exclusive patent license for Pfizer to utilize its enzymatic doggybone DNA (dbDNA).

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Drug Discovery World

SEPTEMBER 27, 2023

Epigenetics: the software of gene regulation Gene activity is the driving force behind our biological processes, and disruptions in normal gene activity can trigger diseases. Unlike genetics, where DNA sequences remain constant, epigenetic modifications are cell type-specific and can change over time due to a balance of enzymatic processes.

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STAT News

APRIL 3, 2023

Federal Trade Commission on Monday ordered DNA sequencing giant Illumina to divest Grail, a cancer diagnostics firm it purchased without regulatory approval, saying the $7.1 billion acquisition “would stifle competition and innovation in the U.S. market for life-saving cancer tests.”

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BioTech 365

AUGUST 17, 2020

4basebio AG / Key word(s): Strategic Company Decision 4basebio AG announces process for spin-off and separate stock market listing for its DNA business 17-Aug-2020 / 11:32 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation … Continue reading →

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Scienmag

JANUARY 4, 2021

Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function.

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BioPharma Reporter

DECEMBER 16, 2020

Thermo Fisher Scientific today announced the construction of a new cGMP plasmid DNA manufacturing facility at its site in Carlsbad, California.

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BioTech 365

SEPTEMBER 16, 2020

Rise of Use of Ancestry.com, 23 and Me Home DNA Kits Revealing Widespread ObGyn/Fertility Doctor Abuses; Leading IVF Attorney Adam Wolf Says Regulation Needed to “Rein in a Profession Run Amuck” WASHINGTON–(BUSINESS WIRE)–Multiple families victimized by “fertility fraud” took action … Continue reading → (..)

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Drug Discovery World

FEBRUARY 27, 2024

The epigenome is a system of reversible marks that regulate how the DNA is read, translated, and used. While DNA encodes the fundamental building blocks of life, the epigenome controls which blocks are accessible for use. T-cells use epigenetic programs to regulate their maturation.

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Outsourcing Pharma

NOVEMBER 1, 2023

Element Biosciences, Inc., will share news of its sequencing methodology and host a workshop on higher accuracy sequencing for improved variant detection in Washington DC from today.

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Pharmaceutical Technology

APRIL 11, 2023

In August 2021, Zydus secured emergency use authorisation (EUA) from the Drugs Controller General of India for its Covid-19 deoxyribonucleic acid (DNA) plasmid vaccine, ZyCoV-D. It carries out operations in the regulated markets of the US and Europe, as well as in Latin America and South Africa.

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Scienmag

JANUARY 11, 2022

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity. Scientists at St. Jude Children’s Research Hospital studied the Vsx2 super-enhancer and its role in the development of the retina.

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Outsourcing Pharma

FEBRUARY 1, 2024

A company building a pipeline of small molecule drugs targeting novel proteins across the DNA mismatch repair (pathway) has announced a further extension to its series B financing round.

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Pharmaceutical Technology

JUNE 15, 2023

The regulator has set 13 February 2024 as a Prescription Drug User Fee Act goal date for the review of Ipsen’s sNDA. Onivyde works by blocking an enzyme called topoisomerase I, which is involved in copying cell DNA.

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Drug Discovery World

OCTOBER 4, 2023

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. Through transcriptional profiling, they found that 141 genes significantly correlated with immobility, with 111 upregulated and 30 downregulated. “We

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Pharmaceutical Technology

MAY 24, 2023

The investigational DNA medicine candidate INO-3107 has been designed for eliciting a targeted T cell response against HPV[human papillomavirus]-6 and HPV-11, the types of HPV that cause RRP and other related diseases. This makes INO-3107 the first RRP product candidate to receive designations from both the EU and the US regulatory agencies.

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Drug Discovery World

MARCH 2, 2023

But the new findings answer a fundamental and longstanding question – how epigenetic proteins regulate the processes of transcription and gene expression, through which our genes are read and translated into proteins. When it gives the green light, H3K4me3 allows RNA polymerase II to move along DNA, transcribing it into RNA as it moves.

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BioPharma Reporter

MARCH 3, 2022

UK headquartered Touchlight has agreed a development and manufacturing pipeline agreement with Swiss company, Versameb.

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