Pharmaceutical Technology

MARCH 28, 2024

Boundless has two assets in clinical trials targeting extrachromosomal DNA in cancer patients.

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Medical Xpress

APRIL 18, 2023

A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR inhibitor ceralasertib showed clinical benefit in pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair deficiencies, according to results from the phase I portion of the phase I/II AcSé-ESMART trial presented at the AACR Annual Meeting (..)

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Scienmag

MAY 26, 2022

A team of researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), have shown that they can use methylation patterns in cell-free DNA (cfDNA) extracted from blood samples to predict which patients with muscle-invasive bladder cancer are likely to benefit from chemotherapy before their (..)

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Outsourcing Pharma

MAY 25, 2023

A company developing small molecule therapeutics targeting DNA Damage Response (DDR) in order to treat patients with a broad range of cancers has its first assay development customer.

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pharmaphorum

JULY 2, 2021

Zydus Cadila has filed for emergency use approval (EUA) in India of its plasmid DNA-based vaccine for COVID-19, which if given a green light could become the first shot of its type to be cleared for widespread use in humans. . The post Zydus Cadila nears world-first human plasmid DNA vaccine approval appeared first on.

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BioPharma Reporter

FEBRUARY 17, 2022

Start-up biotech Alvea has started pre-clinical testing for its DNA vaccine: with clinical trials set to begin as soon as March.

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XTalks

JANUARY 8, 2024

Whether it’s for a treatment for a chronic ambulatory condition, precision medicine or cell and gene therapy, there is a massive uptick in clinical trial complexity. It’s important to make sure that with this increase in clinical trial complexity, we don’t make our trials overly burdensome to sites or patients,” says Markham.

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Scienmag

APRIL 10, 2022

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers — ATR inhibitor elimusertib and PARP inhibitor AZD5305 — are safe and clinically beneficial in treating patients with advanced solid tumors. NEW ORLEANS ? Principal investigator Timothy Yap, M.B.B.S.,

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BioTech 365

JULY 27, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Artios raises $153M to fund DNA damage repair clinical trials.Artios raises $153M to fund DNA damage repair clinical trials ntaylor Tue, 07/27/2021 – 07:43 from FierceBiotech: Biotech … Continue reading →

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pharmaphorum

JANUARY 6, 2021

Pharma companies are always talking about moving ‘beyond the pill’, and Pfizer’s new brand identity embodies that – it’s decades old pill-like logo has been replaced with a DNA double helix that it says reflects its commitment to breakthrough science. Encoded within a successful emblem is a company’s DNA – its history, its future.

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Bio Pharma Dive

OCTOBER 19, 2020

The trial would be the first test of a systemically administered gene editing treatment that uses the Nobel Prize-winning technology to alter DNA.

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XTalks

DECEMBER 28, 2023

BillionToOne, a company specializing in molecular diagnostics, has partnered with Janssen Research & Development, LLC, a Johnson & Johnson division, to conduct the AZALEA Phase III clinical trial globally. The trial is set to occur across the US, the European Union (EU) and selected global locations.

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Bio Pharma Dive

SEPTEMBER 28, 2020

The FDA has suspended the planned start of a late-stage trial of Inovio's experimental shot, dealing another setback to one of the most advanced DNA-based vaccine programs in development.

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Drug Discovery World

APRIL 26, 2024

A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. The post “Game-changing” personalised cancer vaccine enters UK clinical trials appeared first on Drug Discovery World (DDW). in the combination arm and 62.2%

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Pharmaceutical Technology

APRIL 3, 2023

The deal will see Polyplus join the German life science group’s portfolio allowing the latter to leverage expertise in transfection reagents and plasmid DNA for gene therapy. to complete an in-house plasmid DNA facility in Marburg, Germany. “In In February 2023, the mRNA specialist BioNTech invested $43.8m

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pharmaphorum

SEPTEMBER 14, 2021

Startup Rome Therapeutics has raised $77 million in second-round financing to help mine sequences of DNA – which were dismissed for years as ‘junk’ – for hidden treasure. Much of this repeatome is thought to derive from viruses that embedded in our DNA millions of years ago.

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BioTech 365

APRIL 12, 2021

Applied DNA and Evvivax Announce Positive Preliminary Results of Phase I Clinical Trial for LinearDNA™ COVID-19 Vaccine Candidate in Felines Applied DNA and Evvivax Announce Positive Preliminary Results of Phase I Clinical Trial for LinearDNA™ COVID-19 Vaccine Candidate in Felines … Continue reading →

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BioTech 365

JUNE 7, 2021

Applied DNA Reports Veterinary COVID-19 Vaccine Candidate Induces Neutralizing Antibodies in 100% of Trial Cohort Against B.1.1.7, 1.526 Variants and Sets August 2021 Mink Challenge Trial Launch Applied DNA Reports Veterinary COVID-19 Vaccine Candidate Induces Neutralizing Antibodies in … Continue reading →

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BioTech 365

APRIL 16, 2021

Aegis Life Announces Start of Phase 1/2 Trial of the Entos COVID-19 DNA Vaccine, Covigenix VAX-001, with First Participants Dosed Aegis Life Announces Start of Phase 1/2 Trial of the Entos COVID-19 DNA Vaccine, Covigenix VAX-001, with First Participants Dosed … Continue reading →

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Pharmaceutical Technology

MARCH 28, 2023

On March 27, researchers presented new interim results from the Phase III RUBY clinical trial that could indicate a new standard of care for endometrial cancer treatment. GSK’s trial evaluated the programmed death receptor-1 (PD-1)-blocking antibody Jemperli (dostarlimab). GlobalData is the parent company of Pharmaceutical Technology.

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Pharmaceutical Technology

MAY 31, 2023

Interim clinical results from a Phase I trial have demonstrated SNIPR001’s safety in healthy volunteers. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats, provides the opportunity to target and modify specific DNA sequences. CRISPR offers a different approach in the ongoing struggle against antibiotic resistance.

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Drug Discovery World

NOVEMBER 8, 2023

Deepika Khedekar , Associate Centralized Clinical Lead at IQVIA, explains how artificial intelligence could make clinical trials more accurate, accessible and standardised. Tapping into the capabilities of AI One reason AI may accelerate clinical trials is its ability to rapidly process and analyse vast amounts of data.

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Scienmag

JANUARY 20, 2021

Study supports launch of Phase I clinical trial to test a designer DNA agent — an antisense oligonucleotide that targets a gene called IRF4 — in patients with multiple myeloma Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another.

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Scienmag

SEPTEMBER 28, 2020

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial – highlighting the potential of a new class of drugs known as ATR inhibitors. The drug candidate, tested in humans for the first time, was shown to be well tolerated and stopped the growth of tumours […].

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pharmaphorum

NOVEMBER 20, 2020

Just over a year after its first phase 3 trial of its Engensis gene therapy for painful diabetic peripheral neuropathy (DPN) bombed, Helixmith has started dosing patients in a new study. The South Korean biotech says the DNA plasmid-based therapy has been administered to a patient at Innovative Research of West Florida.

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pharmaphorum

JULY 13, 2022

Verve Therapeutics has started dosing patients in a phase 1b trial of its in vivo gene-editing drug for high cholesterol, designed to permanently switch off the PCSK9 gene with a one-shot treatment. Through base editing, drugs replace single nucleotide in the DNA strand with another, without making double-strand breaks (DSBs) in the gene.

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BioTech 365

SEPTEMBER 16, 2020

–(BUSINESS WIRE)–$APDN #COVID19–Applied DNA Sciences, Inc. NASDAQ: APDN) (“Applied DNA” or the “Company”), a leader in Polymerase Chain Reaction (PCR)-based DNA manufacturing that … Continue reading →

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Scienmag

MARCH 15, 2021

The first vaccine has been administered in a comparative adjuvant trial of DNA prime/protein boost HIV vaccine regimens in Kericho, Kenya Credit: U.S. Military HIV Research Program SILVER SPRING, Md.

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STAT News

FEBRUARY 28, 2023

Wheeler is missing the DNA needed to recycle a waste product called lipofuscin that his cells naturally produce. My toddler, Wheeler, will probably not live to adulthood. Juvenile Batten disease — he has the type known as CLN3 — is stealing his childhood. And then this rare disease will steal my child.

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XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial. COVID-19 Clinical Trials.

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BioPharma Reporter

FEBRUARY 13, 2023

Scancell has reported preliminary immunogenicity data from its Phase 1 COVIDITY clinical trial: with the plasmid DNA based COVID-19 vaccine candidates inducing immune responses when delivered via needle-free tech.

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Drug Discovery World

MAY 17, 2023

A first-in-human clinical trial of an experimental oral drug for removing radioactive contaminants from inside the body has begun. The trial is testing the safety, tolerability and processing in the body of escalating doses of the investigational drug product HOPO 14-1 in healthy adults.

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Pharmaceutical Technology

NOVEMBER 3, 2022

The latest approval is backed by 24-week findings from a Phase II clinical trial (Trial 1092) that analysed 25mg Vemlidy versus placebo in 70 paediatric patients who are treatment-naïve and treatment-experienced.

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pharmaphorum

MARCH 31, 2022

UK startup Sano Genetics has raised $11 million in first-round financing to develop its go-between service, which aims to overcome one of the big challenges in clinical research by connecting patients with trial sponsors. The post Sano raises $11m for patient and trial matchmaking platform appeared first on.

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Pharma Business Blog

MAY 14, 2020

In light of that, we would like to invite you to our Pharma & Life Science webinar where we and other industry professionals will be discussing the impact of COVID-19 on the ITX and regulatory DNA on the pharma and life science industry. We look forward to welcoming you to our webinar. Happy to welcome you personally at the webex.

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XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management.

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ACRP blog

MAY 15, 2023

Looking ahead to Clinical Trials Day on May 20, I am excited by the opportunity to work across the industry to address ways we can put patients at the center of the drug development process. Modern trial designs: Earlier this month, the FDA announced it is taking additional steps to support using decentralized clinical trials.

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