Drug Discovery World

APRIL 3, 2023

Also, the large, immunogenic nature of antibodies and protein ligands as therapeutic molecules means our partners are looking for alternative solutions that offer reduced immunogenicity and improved tissue penetration properties. As such, working with large protein delivery vehicles like antibodies can remove these therapeutic benefits.

Antibody 52

Antibody Gene Therapy Gene In-Vitro 52

Roots Analysis

MARCH 11, 2022

Exosomes are known to have some unique functions, such as their ability to alter recipient cell bioactivities, acting like intercellular messengers and also having therapeutic potential in disease diagnostics as well as targeted drug delivery. II are involved in sorting these ubiquitinated proteins. Both ESCRT?I I and ESCRT?II

Manufacturing 52

Manufacturing Protein Drug Delivery Development 52

The Pharma Data

JANUARY 17, 2021

At Gilead he led the organization in the successful filing of numerous New Drug Applications (NDAs) and supplemental label updates across multiple therapeutic areas. Before this, he held various positions at Duke University Medical Center.

Life Science 40

Life Science Drug Delivery Engineer Drugs 40

Drug Discovery World

OCTOBER 18, 2023

Such therapies have become an appealing drug modality for multiple conditions, including monogenic disorders, cancers, and infectious diseases. As such, they offer highly stable expression of human genes, mRNA, and proteins. She received a Ph.D. References 1: U.S. Accessed 26 Jul 23.

Gene Therapy 65

Gene Therapy Gene Clinical Trials Clinical Trials 65

The Pharma Data

JUNE 26, 2021

The PDS Marketing Authorisation Application has also been validated by the European Medicines Agency and is currently under review. Portal is an extension study evaluating the long-term safety and efficacy of PDS in nAMD. 9 Both the Pagoda and Pavilion trials are actively recruiting participants.

Drug Delivery 52

Drug Delivery Clinical Trials Clinical Trials Medicine 52

Drug Discovery World

NOVEMBER 17, 2022

Applying the principles of engineering to biology – redesigning organisms and biological parts to create synthetic components with new abilities – fuels the progression of medicine and gives researchers additional ability to tackle scientific issues. . But those clusters are often inaccessible with current technologies. .

Bacteria 52

Bacteria Engineer Gene Genetics 52

XTalks

AUGUST 30, 2022

One of the biggest challenges with developing therapies to treat CNS disorders is the delivery of systemically administered investigational products (IPs) to the brain, which is limited by the blood-brain barrier. Some methods of direct CNS administration include intrathecal, intraparenchymal and intracerebroventricular (ICV) delivery.

Trials 83

Trials Drug Delivery Drugs Gene 83

The Pharma Data

JANUARY 6, 2021

(“CytoDel” or “the Company”), a privately-held corporation, today announces the publication of preclinical data on the Company’s lead product, Cyto-111, in the peer-reviewed journal, Science Translational Medicine. Cyto-111 was conceived, expressed and purified in the laboratory of Konstantin Ichtchenko, Ph.D., Südhof, M.D.,

Medicine 52

Medicine Antibody Protein In-Vitro 52

Drug Discovery World

NOVEMBER 8, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Kathrin Herbst, PhD, Director of Science & Business Development, Lightcast, on: ‘A new era of single-cell functional profiling for drug discovery’.

Antibody 65

Antibody Engineer Protein Scientist 65

Drug Discovery World

JANUARY 17, 2024

The company aims to advance platform technologies including chemoproteomics, molecular glue and covalent drug discovery, high-throughput screening, protein and antibody engineering, gene and epigenetic editing, gene and cell therapies, drug delivery, and data science.

Drugs 52

Drugs Drug Delivery Life Science Gene 52

Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. James Cooke, PhD, Associate Director, Bicycle Therapeutics, on: ‘Engineering bicyclic peptides for precision targeted medicine’.

Engineer 52

Engineer Antibody Protein In-Vivo 52

The Pharma Data

JANUARY 15, 2021

Food and Drug Administration (FDA) approval of Darzalex Faspro ® (daratumumab and hyaluronidase-fihj), a subcutaneous formulation of daratumumab, in combination with bortezomib, cyclophosphamide and dexamethasone (D-VCd) for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis.[1]

FDA Approval 52

FDA Approval Production Research Doctors 52

Drug Discovery World

NOVEMBER 15, 2023

After a terrific and highly productive era at Imperial College London, I am transferring my labs to the University of Oxford as John Black Professor of Bionanoscience to work across the Kavli Institute for NanoScience Discovery, the Institute of Biomedical Engineering and the Institute of Developmental and Regenerative Medicine.

Research 59

Research Engineer Drug Delivery Scientist 59

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

RNA 40

RNA Protein Genetics Gene Expression 40

The Pharma Data

JANUARY 27, 2021

Utilizing drug delivery platform technologies, BetterLife is refining and developing drug candidates from a broad set of complementary interferon-based technologies which have the potential to engage the immune system to fight virus infections, such as the coronavirus disease (COVID-19) and human papillomavirus.

In-Vitro 52

In-Vitro Containment Drugs Production 52

Pharmaceutical Technology

APRIL 16, 2023

But with the advent of injection site absorption enhancers, drug delivery device innovations, as well as the recent primary container options, the practical subcutaneous self-administration of large-volume parenterals is becoming possible. National Library of Medicine – Silicone Oil Induced Aggregation of Proteins 4.

Protein 130

Protein Containment Drug Delivery Drugs 130