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Subcutaneous Medications and Drug Delivery Systems

Roots Analysis

Given the robust pipeline of biologics, which include monoclonal antibodies, vaccines and other protein-based therapeutic products, subcutaneous medications are being investigated for various clinical candidates across different phases of development.

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Nanoparticle Formulation: A Paradigm Shift towards Novel Drug Delivery

Roots Analysis

Owing to their unique size and physicochemical properties ( surface roughness, surface area, surface energy, crystal structure and shape ), nanoparticles can be widely used as a contrasting agent in medical imaging, a vesicle to cross the blood-brain barrier and a carrier for targeted delivery of genes / drugs, proteins, vaccines and antibiotics.

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Altimmune ditches nasal COVID vaccine on weak trial data

pharmaphorum

Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19, US biotech Altimmune is abandoning the project, saying that it generated weaker than expected immune responses in a phase 1 trial. . The post Altimmune ditches nasal COVID vaccine on weak trial data appeared first on.

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Alnylam sues Pfizer, Moderna over COVID-19 vaccines

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Alnylam claims it is owed a slice of the massive revenues booked by Pfizer and Moderna for their mRNA-based COVID-19 vaccines, because they are both infringing patents its holds on a delivery technology. The post Alnylam sues Pfizer, Moderna over COVID-19 vaccines appeared first on.

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Subcutaneous Biologics: The Unmet Requirement in the Pharmaceutical Space

Roots Analysis

However, several drug delivery devices that enable patients to self-administer their respective medications are now available. Subcutaneous drug delivery systems – the helping hand for patients. The emergence of safer and patient-friendly devices is acting as a strong enabler for subcutaneous delivery of therapeutics.

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Boehringer buys Abexxa, bolstering its immuno-oncology pipeline

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Its lead project is a T-cell receptor (TCR)-like antibody against an HLA molecule associated with intracellular protein NKG2A, an immune checkpoint. Abexxa will form part of its broad push into immuno-oncology, focused on cancer vaccines, oncolytic viruses and T-cell engagers, amongst other treatment strategies.

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Liposome: A Novel Drug Delivery System

Roots Analysis

Furthermore, a wide variety of drugs and macromolecules, including DNA , proteins, and imaging agents, can be encapsulated in liposomal vesicles due to their unique ability to entrap both lipophilic and hydrophilic substances. The various therapeutic applications of liposomes in drug delivery have been highlighted in the figure.