Drug Discovery World

FEBRUARY 1, 2024

Microbial control within biopharmaceutical manufacturing is a critical quality control to help ensure drug products are free from viable microorganisms. Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

Drug Discovery World

FEBRUARY 22, 2024

Microbial control within biopharmaceutical manufacturing is a critical quality control to help ensure drug products are free from viable microorganisms. Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods.

Production 52

Production Genotype Manufacturing Gene Therapy 52

Drug Discovery World

FEBRUARY 15, 2024

Microbial control within biopharmaceutical manufacturing is a critical quality control to help ensure drug products are free from viable microorganisms. Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods.

Production 52

Production Genotype Manufacturing Gene Therapy 52

Drug Discovery World

FEBRUARY 8, 2024

Microbial control within biopharmaceutical manufacturing is a critical quality control to help ensure drug products are free from viable microorganisms. Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

Drug Discovery World

FEBRUARY 1, 2024

Microbial control within biopharmaceutical manufacturing is a critical quality control to help ensure drug products are free from viable microorganisms. Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

pharmaphorum

JANUARY 24, 2023

Drug development has long been an issue for the pharma industry, due to the expense and the high failure rate of potential treatments. Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

Scienmag

MAY 16, 2021

The investigational drug evinacumab reduced triglycerides in patients with severe hypertriglyceridemia (sHTG) and a history of hospitalizations for acute pancreatitis in a phase 2 global study led by Mount Sinai.

Antibody 45

Antibody Genotype Drugs Clinical Trials 45

Drug Discovery World

JANUARY 20, 2023

Standard treatment for some cancers now include genotyping or molecular imaging in living patients. The post New whitepaper on trends in precision medicine: Cancer appeared first on Drug Discovery World (DDW). This is an extraordinarily exciting time to be involved in precision medicine for cancer.

Medicine 52

Medicine Genotype Protein RNA 52

Drug Discovery World

OCTOBER 4, 2022

Within the past year, BioIVT has undertaken a programme to annotate thousands of biospecimens with next-generation sequencing data (NGS), creating the largest biorepository of biospecimens with mutation or genotype data. . The post BioIVT expands into new therapy areas with Fidelis acquisition appeared first on Drug Discovery World (DDW).

Genotype 52

Genotype Clinical Research Research Drugs 52

Pharmaceutical Technology

JUNE 6, 2023

The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Hormones 100

Hormones In-Vitro Genotype Bacteria 100

Drug Discovery World

JULY 3, 2023

The OXEGENE dataset contains anonymised genotype data including disease stage and infertility status, from 1,000 surgically confirmed patients. PrecisionLife also aims to find novel drug targets for these disease mechanisms with biomarkers linking them to the patients who will benefit from the development of new treatments.

Genetics 52

Genetics Genotype Medicine Licensing 52

Delveinsight

DECEMBER 13, 2020

alcohol, certain drugs) and autoimmune diseases can also cause hepatitis. Interferons are naturally occurring proteins in the body; recombinant IFNa is the protein-based drug that works to mobilize the body’s natural immune system to fight disease. Both drugs resulted in inhibition of HCV replication.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Pharmaceutical Technology

DECEMBER 15, 2022

High interest has sparked across the CFD drug space as more experts are becoming aware of the clinical efficacy and large market opportunity of using HFC products to treat various AFD indications, including surgeries involving massive blood loss and unexpected trauma. While they treat the symptoms of CFD, they are not curative.

Marketing 130

Marketing Production Genotype Development 130

Bioengineer

JANUARY 16, 2024

Importantly, a triple mutant scenario with EGFR L858R/T790M/C797S or EGFRexon19del/T790M/C797S genotype may occur in patients with T790-positive NSCLC receiving osimertinib in second or later lines. Real-world cohorts report a prevalence of C797 mutations between 11% and 29%. Reported changes include L718Q and L718V.

Genome 119

Genome Genomics Protein In-Vitro 119

The Pharma Data

OCTOBER 9, 2021

Food and Drug Administration (FDA) Antimicrobial Drugs Advisory Committee (AMDAC) voted unanimously to recommend use of maribavir (TAK-620) for the treatment of refractory cytomegalovirus (CMV) infection and disease with genotypic resistance to ganciclovir, valganciclovir, foscarnet or cidofovir in transplant recipients.

Drugs 52

Drugs Genotype Bioavailability Medicine 52

Drug Discovery World

MAY 22, 2023

The collaboration will accelerate findings by PrecisionLife working with the Motor Neurone Disease Association and leading clinicians at King’s College London and the University of Sheffield to analyse genotyped patient data and find novel genetic insights into the disease.

Medicine 52

Medicine Genotype Genetics Clinical Trials 52

pharmaphorum

AUGUST 11, 2022

More than 60 percent of all American adults take prescription drugs , amounting to approximately 131 million individuals. These drugs have been rigorously tested by regulatory bodies around the world before they’re made available to ensure they work as labelled, but despite that, adverse events crop up.

Genome 98

Genome Genomics Genetics Drugs 98

pharmaphorum

JULY 13, 2021

That could present a window of opportunity to try to introduce changes to lifestyle such as physical exercise or non-drug therapies like memory or cognitive training that – in theory at least – could help slow down progression to symptomatic Alzheimer’s. It could potentially also help to select patients for drug therapies.

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Genotype Scientist Drugs Research 111

pharmaphorum

JANUARY 29, 2023

On Friday, Novartis said that the phase 3 STAND trial of Adakveo (crizanlizumab) found no statistically significant difference between the drug and placebo on annualised rates of vaso-occlusive crises (VOCs) – the excruciatingly painful attacks that intermittently affect patients with SCD. compared to 2.98

Genotype 52

Genotype Trials Antibody Regulation 52

Drug Discovery World

SEPTEMBER 20, 2022

Each circle represents a disease-associated SNP genotype, edges represent their co-association in patients in disease signature(s), and colours represent distinct patient sub-populations. The post Study reveals first genetic links in ME and Chronic Fatigue Syndrome appeared first on Drug Discovery World (DDW).

Genetics 52

Genetics Biobanking Genotype Gene 52

The Pharma Data

NOVEMBER 2, 2020

ONWARD is investigating Adial’s lead drug candidate, AD04, as a therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in persons with certain target genotypes related to the serotonin transporter and receptor genes. Key ONWARD highlights include: All 25 planned investigative sites are active.

Trials 52

Trials Genotype Marketing Production 52

pharmaphorum

JANUARY 29, 2019

How the shift towards cancer as a phenotype/genotype is being applied in clinical trials and how they are run •What are co-clinical trials and why could they hold the key to answering unmet need in cancer treatment and beyond into broader drug development? •What are the implications from these changes for clinical trials?

Medicine 52

Medicine Genome Genomics Clinical Trials 52

Drug Discovery World

FEBRUARY 27, 2024

Reece A: What are some of the human limitations to current drug discovery research for immunotherapies? Reece A: AI has typically been used to fast-track certain stages of drug discovery and development but NOETIK is using it to tackle fundamental issues in cancer. Can you tell us about this approach?

Genome 52

Genome Genomics Genotype Medicine 52

The Pharma Data

NOVEMBER 18, 2020

HIV drug resistance is caused by changes in the genetic structure of HIV that affects the ability of drugs to block the replication of the virus. Minimizing the emergence and transmission of HIV drug resistance is a vital part of global. WHO has developed survey methods to monitor pretreatment HIV drug resistance.

Drugs 52

Drugs Genotype Medicine Development 52

Roots Analysis

APRIL 28, 2024

Absence of Biomarkers for Diagnosis: Due to the absence of genotype-phenotype correlations and prognostic markers, there have been challenges in the diagnosis and treatment of rare kidney diseases. Such obstacles lead to the limited use of such mouse models for development of rare kidney disease drug.

Genetics 40

Genetics Genotype Development FDA Approval 40

XTalks

APRIL 15, 2021

Experts from Servier and Genuity Science recently spoke on a webinar about using genomics data to drive drug development in heart failure and identify new targets for novel therapeutics. However, these drugs have shown limited effectiveness in treating HFpEF. Case Study: Genomic Approaches in Coronary Artery Disease Drug Development.

Development 98

Development Drugs Genome Genomics 98

XTalks

MARCH 3, 2021

The US Food and Drug Administration (FDA) has granted approval to Nulibry (fosdenopterin) for reducing the risk of death associated with molybdenum cofactor deficiency type A (MoCD Type A), making it the first treatment for the ultra-rare, genetic metabolic disorder. The approval was granted to BridgeBio Pharma, Inc.

FDA Approval 64

FDA Approval Genotype Clinical Trials Clinical Trials 64

The Pharma Data

MARCH 7, 2022

Food and Drug Administration announced it has made a low-risk determination for the marketing of products, including food, from two genome-edited beef cattle and their offspring after determining that the intentional genomic alteration (IGA) does not raise any safety concerns (low-risk determination). The FDA, an agency within the U.S.

Genome 52

Genome Genomics Production Marketing 52

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Biobanking will continue to play an integral role in accelerating drug discovery and development, which will necessitate access to a larger array of biological samples.

Research 98

Research Biobanking Drugs Genome 98

Delveinsight

AUGUST 25, 2021

The pharmaceutical industry finds, develops, manufactures, and promotes medicines or pharmaceutical drugs for usage as medications that are administered (or self-administered) to patients in order to cure, vaccinate, or relieve symptoms. Pharmaceutical companies may deal in both generic and brand-name drugs as well as medical devices.

Vaccination 98

Vaccination Vaccine Sales Drugs 98

The Pharma Data

NOVEMBER 10, 2020

“They will help researchers mechanistically assess target engagement in clinical trials,” and also will be used in clinical practice to identify the right drugs for the right patients, Howard Fillet, M.D., Importantly, “It demonstrated a lack of drug interference for each drug studied,” Dage said. ADNI trial.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Antibody 52

pharmaphorum

NOVEMBER 10, 2021

This database should support automatic importation from hospitals, laboratories and surveillance networks and link to genotypic data when available.”. When new antimicrobials are brought to market, good stewardship requires that older drugs be used first, even if there were no difference in price.”. One health.

Medicine 105

Medicine Genome Genomics Genotype 105

The Pharma Data

DECEMBER 9, 2020

Vigil’s pipeline strategy is to target these diseases by combining a high-level understanding of microglia physiology, disease genotyping, and patient phenotyping to identify specific genetic variations associated with microglial dysfunction. It’s like taking out the trash. Tranquis Therapeutics.

Marketing 52

Marketing In-Vivo Protein In-Vitro 52

The Pharma Data

DECEMBER 9, 2020

Our focus on partnering to accelerate patient access to innovative medicines underscores our commitment to advancing breakthroughs in biomedicine such as antibody drug conjugates, cell therapy, RNAi and more, Ed Zhang, company co-founder, chief operating and business officer, said in a statement. “We million in a second financing round.

In-Vivo 52

In-Vivo In-Vitro Antibody Development 52

Drug Discovery World

FEBRUARY 9, 2024

DDW recently hosted a webinar ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, supported by DefiniGEN. Chris explained that DefiniGEN is a liver cell company focussed on hepatocytes, particularly supporting the drug development industry in producing liver therapies. Watch on demand.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

SEPTEMBER 5, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Development 59

Development Drugs Protein Genotype 59

Drug Discovery World

SEPTEMBER 26, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Development 52

Development Drugs Protein Genotype 52