Medical Xpress

APRIL 26, 2023

Cambridge scientists have shown how the brain's ability to clear out toxic proteins is impaired in Huntington's disease and other forms of dementia—and how, in a study in mice, a repurposed HIV drug was able to restore this function, helping prevent this dangerous build-up and slowing progression of the disease.

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Protein Drugs Scientist 75

STAT News

OCTOBER 13, 2022

Every two years since 1994, scientists have come together for an experiment — better described as a competition — where teams of computational biologists try to predict what proteins will look like in 3D given their amino acid sequence. In 2020, its successor, AlphaFold2, achieved near-perfect scores.

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Protein Scientist Drugs Development 111

Drug Discovery World

MARCH 5, 2024

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored ‘dark side’ of the neuraminidase (NA) protein head.

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Antibody Protein Vaccination Vaccine 59

Medical Xpress

FEBRUARY 16, 2023

Scientists at Scripps Research, with collaborators in Japan, have discovered how a "poisoned" form of a protein could set off a cascade of events that encourage the growth of some cancers. In mice with colon cancer, the drug prevented or dramatically slowed formation of tumors.

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Protein Scientist Drugs Research 75

Drug Discovery World

NOVEMBER 25, 2022

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs. . Better, less toxic drugs. Understanding tankyrase. We have shown how tankyrase is switched on and can go from a ‘lazy’ enzyme to an active one.

Protein 52

Protein Drugs Scientist Research 52

Scienmag

APRIL 8, 2021

Credit: © Terence Strick The Mfd protein repairs bacterial DNA, but can also, to scientists’ surprise, promote mutation. Understanding this second “role” of the Mfd protein opens up opportunities for combating antibiotic resistance, and also the resistance of tumours to anti-cancer drugs and therapies.

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Protein DNA Scientist Drugs 98

Scienmag

JULY 4, 2022

Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) […].

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Scientist Protein Drugs Medicine 71

Drug Discovery World

NOVEMBER 7, 2022

Scientists have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective. . CELMoDs are designed to attack cancer by binding to a regulatory protein called cereblon, which then triggers the degradation of key cancer-driving proteins. . Understanding the problem.

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Scientist Drugs Protein Research 52

BioPharma Reporter

MAY 3, 2023

Protein drugs are notoriously difficult to deliver orally â but scientists have developed a new type of oral capsule that could deliver insulin and other similar drugs.

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Insulin Scientist Development Protein 52

Scienmag

MAY 4, 2022

Scientists at Emory have revealed widespread distortions of a cell’s protein interaction machinery resulting from cancer-causing mutations. They developed a process resembling ground-penetrating radar, for its ability to map the hidden landscape of anticancer drug opportunities. The results are published in Cell.

Protein 59

Protein Scientist Development Drugs 59

Drug Discovery World

FEBRUARY 13, 2024

It goes on to show that NX-2127, a potent targeted protein degrader with differentiated activity against BTK and IKZF1/3, can overcome this resistance across a broad range of acquired mutations. The post Protein degrader overcomes resistance in B-cell malignancies appeared first on Drug Discovery World (DDW).

Protein 52

Protein Medicine Scientist Research 52

Drug Discovery World

MARCH 30, 2023

Salipro Biotech, in collaboration with AstraZeneca, has published data from a study which describes a novel method to directly extract membrane proteins from cells into lipid Salipro nanoparticles, enabling structure-function analysis using surface plasmon resonance (SPR) and cryo-electron microscopy (cryo-EM) for challenging drug targets.

Protein 52

Protein Engineer Drugs Scientist 52

Drug Discovery World

FEBRUARY 14, 2024

While a typical chemisty, manufacturing and controls (CMC) timeline from DNA to Investigational New Drug (IND) application in 2015 would have been approximately 24 months, by 2023 the same pathway was expected to take only 10 months. In particular, we must work to accelerate recombinant protein vaccine development.

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Protein Vaccination Vaccine Manufacturing 59

The Pharma Data

APRIL 26, 2022

A drug used to treat asthma and allergies can bind to and block a crucial protein produced by the virus SARS-CoV-2, and reduce viral replication in human immune cells, according to a new study by researchers at the Indian Institute of Science (IISc). “The anti-HIV drug (saquinavir) showed good affinity, but not good stability.”

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Protein Drugs Allergies FDA Approval 52

Drug Discovery World

DECEMBER 20, 2022

A project creating a new class of therapeutic proteins to modulate cell signalling has been accepted into the BioInnovation Institute (BII) Bio Studio programme. Its Bio Studio program aims to foster the creation of new life science start-ups based on research from world-class scientists to benefit people and society.

Protein 52

Protein Life Science Antibody Business Development 52

Drug Discovery World

MAY 18, 2023

Scientists in Japan have used a novel technique to identify a protein complex degraded by autophagy that has a possible role in liver cancer. p62 protein forms a membrane-less cytosolic organelle called p62 body and helps in the selective removal of toxic cellular waste through autophagy.

Protein 52

Protein Scientist Medicine Regulation 52

Drug Discovery World

NOVEMBER 15, 2023

or N-type) calcium channel is the target for three clinically available drugs, including gabapentin (sold under brand names including Neurontin) and pregabalin (Lyrica), which are widely used to treat nerve pain and epilepsy. A first-in-class small molecule Protein CRMP2 is a key regulator of the Cav2.2 The Cav2.2 (or

Scientist 52

Scientist Protein Regulation Clinical Trials 52

Scienmag

JULY 22, 2021

New UCLA research identifies TAF12 as a potential cancer drug target FINDINGS Scientists from the UCLA Jonsson Comprehensive Cancer Center have identified a key protein, transcription factor TAF12, that plays a critical role in the formation of a preinitiation complex, which consists of over one hundred proteins that are necessary for the transcription (..)

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Scientist Protein Drugs Research 75

Scienmag

DECEMBER 28, 2020

iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells Credit: Kyoto University iCeMS In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein (..)

Protein 40

Protein Drugs Scientist 40

Drug Discovery World

MAY 24, 2024

The headline news this week emphasises the importance of shared expertise and collaboration, whether that be between nations, companies or research institutions, to enable the greatest advances in drug discovery. The post This week in drug discovery (20-24 May) appeared first on Drug Discovery World (DDW).

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Drugs Genetics Protein Scientist 52

Scienmag

NOVEMBER 23, 2020

Rice scientists’ atomic resolution protein models reveal new details about protein binding Credit: Illustration by Mingchen Chen/Rice University HOUSTON – (Nov. 23, 2020) – Knowing precisely where proteins are frustrated could go a long way toward making better drugs.

Protein 95

Protein Drugs Scientist 95

Drug Discovery World

OCTOBER 26, 2022

A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. . Identifying the proteins . Click’ chemistry .

Protein 52

Protein Genetics Containment Research 52

Scienmag

NOVEMBER 17, 2020

Credit: © Andreas Reicher / CeMM Until now, scientists typically studied the changes of proteins and their roles in the cell by using a fluorescent tag to label and follow one protein at a time. This approach limited the number of proteins that could be studied and precluded unbiased discovery approaches.

Protein 52

Protein Scientist Drugs Research 52

Medical Xpress

FEBRUARY 23, 2023

Scientists at Open Targets, EMBL's European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins.

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Bioinformatics Drugs Protein Scientist 75

Drug Discovery World

APRIL 18, 2024

Nutcracker Therapeutics’ prostate cancer mRNA drug candidate NTX-470 successfully engaged CD3 T cells, while retaining low bystander activity and reduced off-tumour binding, according to data presented at the 2024 AACR Annual Meeting.

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Engineer Drugs RNA Scientist 52

Scienmag

JUNE 29, 2022

In ACS Infectious Diseases, scientists now report that apratoxin S4, an anticancer drug candidate that targets a […]. More than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2.

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Protein Scientist Drugs Research 87

Scienmag

MARCH 18, 2021

— Scientists at the University of Wisconsin-Madison have developed a way to use a cell’s own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. MADISON, Wis. By eliminating them, researchers believe […].

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Protein Scientist Development Drugs 49

Drug Discovery World

NOVEMBER 22, 2022

The new strategy aims to implement new approaches to target cancer – by setting up streamlined processes to prioritise potential drug targets and employing state-of-the-art technology to eradicate cancer proteins from cells. .

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Scientist Immune Response Research Drugs 52

Scienmag

NOVEMBER 17, 2020

Scientists have established a new method to image proteins that could lead to new discoveries in disease through biological tissue and cell analysis and the development of new biomaterials that can be used for the next generation of drug delivery systems and medical devices.

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Protein Drug Delivery Systems Drug Delivery Scientist 67

NY Times

NOVEMBER 30, 2020

Researchers at DeepMind say they have solved “the protein folding problem,” a task that has bedeviled scientists for more than 50 years.

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Protein Scientist Drugs Research 123

pharmaphorum

NOVEMBER 12, 2021

Researchers in the US have developed an artificial intelligence-based tool that is able to predict COVID-19 symptoms and suggest which FDA-approved drugs might be used to treat patients. The tool meanwhile could also be applied to new outbreaks of other novel viral infections as they emerge, according to the scientists.

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Doctors Doctor Drugs Gene Expression 135

Drug Discovery World

DECEMBER 1, 2023

The key drug discovery news this week focuses on experimental approaches to the treatment of some of the most challenging diseases, including a mathematical model that can simulate Alzheimer’s progression and using CRISPR gene editing to ‘shred’ tumours. Can a plant-based discovery pave the way for new drug treatments?

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Gene Editing Drugs Scientist Gene 52

NY Times

FEBRUARY 5, 2021

No drug could touch a quivering protein implicated in a variety of tumors. Then one chemist saw an opening.

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Scientist Protein Drugs Clinical Trials 104

Drug Discovery World

APRIL 22, 2024

Scientists have discovered how skin cancer cells shapeshift based on their environment – enabling them to spread through the body and cause a metastatic cancer. The discovery of two genes responsible for sensing the environment and adapting cell shape could offer potential new drug targets to stop cancer from metastasising.

Drugs 52

Drugs Gene Scientist Research 52

BioTech 365

NOVEMBER 17, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Drug discovery: First highly scalable method to monitor protein levels and localizations.Until now, scientists typically studied the changes of proteins and their roles in the cell by … Continue reading →

Protein 40

Protein Drugs Scientist Research 40

Drug Discovery World

APRIL 11, 2023

The Carterra 2023 Symposia Series ‘Unlocking High-Throughput Biology and Drug Discovery’ is now open for registrations. Join industry-leading scientists from GSK, Oxford University, LifeArc, Alloy Therapeutics, Sanofi, and Carterra on April 19, 2023 in Cambridge, UK for this one-day, science-filled experience.

Drugs 52

Drugs Protein Antibody Scientist 52

Drug Discovery World

NOVEMBER 23, 2022

Scientists have found a new drug treatment that can slow the progression of neurodegenerative disease in mice. It found that by using a novel drug, which selectively activates a brain protein called the M1-receptor, the lifespan of mice suffering from neurodegeneration could be extended. .

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Drugs Scientist Protein Research 97