Thu.Oct 15, 2020

Lilly wagers $135M on a startup's plan to stop neurodegeneration

Bio Pharma Dive

The drugmaker is acquiring Disarm Therapeutics, which was formed based on research into a specific enzyme's central role in the breakdown of axons

Single-Arm Trials Using Real-World Evidence for Rare Disease Product Development

Camargo

As a sponsor designs clinical studies, the respective comparison control groups become a critical factor to consider.

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Fujifilm to help Lilly make COVID-19 antibody drug

Bio Pharma Dive

Lilly has asked the FDA for emergency clearance of the therapy, although a study safety review and an unrelated manufacturing inspection could complicate the request

Pharma and insurers raking in the cash

World of DTC Marketing

HEY NOW : Most companies struggled in the second quarter as the coronavirus pandemic froze the economy, but health insurers like UnitedHealth heavily benefited as people held off on going to the doctor or hospital, resulting in fewer medical claims that needed to be paid. In addition, pharma profit margins remain very high. UnitedHealth Group registered more than $6.6

Remdesivir Fails to Prevent Covid-19 Deaths in Huge Trial

NY Times

An antiviral widely used to treat hospitalized patients did not lower the mortality rate in a multinational trial

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Disruptive Technologies and Mature Regulatory Environment Vital for Cell Therapy Maturation

BioSpace

Immuno-oncology and CAR T cells energized the field of regenerative medicine, but for cell and gene to deliver on their promises, new, disruptive technologies and new modes of operation are needed

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More Trending

Pfizer CEO Anticipates EUA for COVID-19 Vaccine in Late November

BioSpace

Pfizer will not seek Emergency Use Authorization for its COVID-19 vaccine until the end of November even if the readout from a Phase III study expected later this month is positive

Accelerating the digital approval process

Pharma Phorum

The boom in digital tech over COVID means that pharma can move faster than ever – but the industry’s traditional processes for asset approval are still holding timelines back. David Reily examines how pharma companies are responding to the increased burden of asset approval with new ways of working.

Immunotherapy combo halts rare, stage 4 sarcoma in teen

Scienmag

Moderna Works With International Regulators to Speed Up COVID-19 Vaccine Review Process

BioSpace

Moderna is working with international regulators to accelerate approval of the company’s COVID-19 vaccine candidate, mRNA-1273

When good governments go bad

Scienmag

History shows that societies collapse when leaders undermine social contracts Credit: (c) Linda Nicholas, Field Museum All good things must come to an end.

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EMA confirms eligibility for submission of Moderna’s COVID-19 vaccine

Pharma Times

Primes company to submit vaccine candidate for rolling review

Laser technology measures biomass in world’s largest trees

Scienmag

Credit: Mat Disney Laser technology has been used to measure the volume and biomass of giant Californian redwood trees for the first time, records a new study by UCL researchers.

Manufacturing a Personalized Cellular Universe: 3D Bioprinting in the Biotech Industry

BioSpace

By using naturally-derived scaffolds, human cells and other biocompatible materials, 3D bioprinting has ushered in opportunities for researchers to design, print and optimize patient personalized tissues for purposes ranging from transplantation to drug testing

COVID: women are less likely to put themselves in danger

Scienmag

Women’s attitudes and behaviors may have contributed to their reduced vulnerability and mortality.

WHO Study Casts Doubt on Effectiveness of Gilead's Remdesivir for COVID-19

BioSpace

The WHO’s SOLIDARITY clinical trial evaluated remdesivir and three other drugs in 11,266 hospitalized COVID-19 patients and found that none of the drugs “substantially affected mortality” or decreased the need to ventilate patients

Oncotarget: Geriatric nutritional risk index – prognostic marker of esophageal carcinoma

Scienmag

Oncotarget Volume 11, Issue 29 reported that In multivariate analyses, serum albumin, GNRI, pathological tumor-node-metastasis stage, and tumor differentiation were independent prognostic factors for CSS. Credit: Correspondence to – Noriyuki Hirahara – norinorihirahara@yahoo.co.jp

Virus strain change should not affect COVID-19 vaccine candidates, say researchers

BioPharma Reporter

Potential vaccines for COVID-19 should not be affected by changes in SARS-CoV-2 seen to date, nor are they likely to need to be redeveloped seasonally, according to Australian scientists. Bio Developments

NASA awards $2.8 million to Purdue’s Indiana Space Grant Consortium

Scienmag

Credit: Purdue University/Chris Adam WEST LAFAYETTE, Ind. – The Indiana Space Grant Consortium, headquartered at Purdue University, has received a $2.8 million grant from NASA to support student and faculty learning projects.

UK Moves Closer to Human Challenge Trial for COVID-19 Vaccine | 2020-10-19

The Pharma Data

UK-based contract research organization Open Orphan said it is in advanced negotiations with the British government and other partners for a human challenge trial of a COVID-19 vaccine.

Supergene discovery leads to new knowledge of fire ants

Scienmag

The research could help development of new pest control methods Credit: UGA A unique study conducted by University of Georgia entomologists led to the discovery of a distinctive supergene in fire ant colonies that determines whether young queen ants will leave their birth colony to start their own new colony or if they will join […].

Moderna Works With International Regulators to Speed Up COVID-19 Vaccine Review Process

The Pharma Data

Moderna is working with international regulators to accelerate approval of the company’s coronavirus disease 2019 (COVID-19) vaccine candidate, mRNA-1273, which is currently leading the global COVID-19 vaccine race alongside vaccine candidates from AstraZeneca, Pfizer and Johnson & Johnson.

FSU researchers find diverse communities comprise bacterial mats threatening coral reefs

Scienmag

Credit: Courtesy of Ethan Cissell TALLAHASSEE, Fla. — Researchers are learning more about the brightly colored bacterial mats threatening the ecological health of coral reefs worldwide.

Avalyn Pharma Reports Update in Ongoing Idiopathic Pulmonary Fibrosis Trial

The Pharma Data

16, 2020 10:00 UTC. SEATTLE–( BUSINESS WIRE )– Avalyn Pharma Inc. ,

Bark beetle outbreaks benefit wild bee populations, habitat

Scienmag

Credit: Seth Davis/Colorado State University When southern Rocky Mountain forests are viewed from a distance these days, it may not look like much is left. Large swaths of dead, standing Engelmann spruce trees tell the tale of a severe regional spruce beetle epidemic in its waning stages.

Disruptive Technologies and Mature Regulatory Environment Vital for Cell Therapy Maturation

The Pharma Data

Immuno-oncology and CAR T cells energized the field of regenerative medicine, but for cell and gene to deliver on their promises, new, disruptive technologies and new modes of operation are needed.

World’s longest-running carbon dioxide measurement receives continuation funding

Scienmag

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Y-mAbs Announces Update on Naxitamab and Omburtamab in Neuroblastoma

The Pharma Data

NEW YORK, Oct. 16, 2020 (GLOBE NEWSWIRE) — Y-mAbs Therapeutics Inc.

Study reveals most effective drugs for common type of neuropathic pain

Scienmag

Clinical study tested four different types of medications for efficacy, tolerability and adverse effects Credit: Justin Kelley More than 20 million people in the U.S. suffer neuropathic pain.

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BioSpace Movers & Shakers, Oct. 16

The Pharma Data

Assembly Biosciences – Former Gilead Sciences CEO John McHutchison, currently president and CEO of Assembly, was named the recipient of the Advance 2020 Global Impact award. The Advance awards recognize the work of remarkable global Australians making an extraordinary impact worldwide.

Researchers develop framework to identify health impacts of self-driving vehicles

Scienmag

They identified 32 transportation-related risk factors that affect health Credit: Texas A&M University College of Engineering Autonomous vehicles (AV) are the wave of the future in the automobile industry, and there’s extensive discussion about the impacts on transportation, society, the economy and the environment.

Cullgen Announces “Featured Article” Publication of First in Class TRK Protein Degraders in Journal of Medicinal Chemistry

The Pharma Data

16, 2020 09:20 UTC. SAN DIEGO–( BUSINESS WIRE )– Cullgen Inc. ,

Gladstone investigators receive 4D Nucleome award from the NIH

Scienmag

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Data Presented at TCT Connect Finds Pre-PCI Use of Impella for AMI Cardiogenic Shock is Associated with Higher Survival, Particularly in Women

The Pharma Data

16, 2020 11:05 UTC. DANVERS, Mass.–( –( BUSINESS WIRE )– Two studies of AMI cardiogenic shock (AMICS) patients found higher survival when Impella was placed pre-PCI, compared to when Impella was placed after PCI.