Drug Discovery World

FEBRUARY 13, 2023

Diseases ranging from cancer to viral immune response, from cardiovascular to reproductive health, and from metabolic to nervous systems all have the potential to benefit from in-depth transcriptomics. Transcriptomics are a necessary compliment to the development of precision medicine therapy approaches in many different disease areas.

RNA 52

RNA Drugs Gene Expression Gene 52

pharmaphorum

FEBRUARY 22, 2021

That is concentrating on determining where the vector integrated into the chromosomes of the two patients with cancer, and if that has resulted in changes to gene expression in neighbouring areas. The case comes just weeks after UniQure halted a trial of its haemophilia B gene therapy AMT-061 after an unexpected case of liver cancer.

Gene Therapy 52

Gene Therapy Gene Gene Sequencing Gene Expression 52

pharmaphorum

FEBRUARY 9, 2021

InteRNA is focusing on the development of gene-silencing drugs based on microRNA, naturally occurring, non-coding strands of RNA that are thought to regulate gene expression in cells.

Trials 57

Trials Gene Silencing RNA Gene Expression 57

Pharma Marketing Network

DECEMBER 21, 2020

Although this approach “silences” the output of genes (by disrupting messenger RNA [mRNA]), the lack of specificity suggests the possibility of direct action on genes in the nucleus. This relinquishes many of the perceived benefits of RNAi therapies that distinguish them from gene therapy (e.g.,

Genetics 52

Genetics Medicine Gene Therapy Marketing 52

Drug Discovery World

OCTOBER 17, 2023

Analysing spatial changes during disease progression or treatment response is key to fully understand pathologies. RA: With spatial biology being cross-disciplinary – in that it uses techniques in both gene expression analysis and immunofluorescence – is expertise in the field limited?

Gene Expression 52

Gene Expression Drugs Protein Gene 52

Drug Discovery World

FEBRUARY 6, 2023

RNA-Sequencing (RNA-Seq) is a revolutionary technology that enables researchers to assess gene expression changes in thousands of genes over time. Results provide deep insights into mechanistic processes, such as which innate and adaptive immune system processes are activated following vaccination and when.

Big Data 52

Big Data RNA Bioinformatics Vaccination 52

The Pharma Data

JULY 8, 2021

Specifically, tezepelumab targets and blocks thymic stromal lymphopoietin (TSLP), a key epithelial cytokine that sits at the top of multiple inflammatory cascades and initiates an overreactive immune response to allergic, eosinophilic and other types of airway inflammation associated with severe asthma.(24,25). EMJ Allergy Immunol.

Allergies 52

Allergies Trials In-Vivo Medicine 52

Drug Discovery World

DECEMBER 15, 2022

While viral vectors can be highly active, they can lead to only transient expression (rAAV, AdV), can lead to adverse immune responses (AdV) or can integrate randomly into the genome (LV). Each comes with its own drawbacks, including immunogenicity, size restrictions, and off-target effects 6.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

The Pharma Data

DECEMBER 27, 2020

STP705 is a small interfering RNA (siRNA) therapy that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to knock down both TGF-beta1 and COX-2 gene expression. GA Depot is a long-acting injection of the approved Glatiramer Acetate products (Copaxone and its generic formulations).

Trials 52

Trials Antibody Gene Therapy Clinical Trials 52

The Pharma Data

NOVEMBER 9, 2020

Specifically, tezepelumab targets and blocks TSLP, a key epithelial cytokine that sits at the top of multiple inflammatory cascades and initiates an overreactive immune response to allergic, eosinophilic and other types of airway inflammation associated with severe asthma. EMJ Allergy Immunol. 2018; 3: 60-9. J Allergy Clin Immunol.

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Trials Production Sales Manufacturing 52