Drug Discovery World

NOVEMBER 7, 2022

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases. . Consequently, the UK has established itself at the forefront of diagnostic whole genome sequencing. Context .

Genome 52

Genome Genomics Genetics Genetic Disease 52

Drug Discovery World

AUGUST 16, 2023

Decoding ‘junk DNA’ The Human Genome Project and subsequent studies discovered that most of our DNA (approximately 98%) does not actually code for proteins, with humans having approximately 20,000 tox 25,000 protein-coding genes. This leads to potentially severe, debilitating and unbearable toxicities for patients.

RNA 52

RNA Genome Genomics DNA 52

Pharmaceutical Technology

JUNE 30, 2022

Earlier this month, scientists from Cambridge University and the Madrid-based National Cancer Research Center described a novel framework tracking chromosomal instability and copy number changes in particularly deadly cancers. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.

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Genome Project Genome Genomics DNA 130

Drug Discovery World

SEPTEMBER 20, 2022

To develop safe and effective gene therapies, researchers need confidence that genomic data is both complete and accurate. This considerable magnitude of difference in read length affords researchers a more complete and accurate view of genomic variation. For years now the UK has been somewhat of a leader in genomic research.

Gene Therapy 52

Gene Therapy Gene Genome Genomics 52

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

Genome 101

Genome Genomics Genetics Genome Project 101

pharmaphorum

JANUARY 24, 2023

The cost of testing per human genome in 2006 was approximately $14 million , and in less than two decades, an average consumer-purchased genetic test costs $100. The same is becoming true for the healthcare industry, and one of the first major breakthroughs in the area was the 100,000 Genomes Project.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

Genome 79

Genome Genomics Genetics Genome Project 79

pharmaphorum

MARCH 25, 2021

The COSMIC (Catalogue of Somatic Mutations in Cancer) database, operated by the Wellcome Sanger Institute, grew out of the work of the Cancer Genome Project and has been gathering data on mutations associated with specific cancers for almost 17 years. The post COSMIC database matches drugs to cancer mutations appeared first on.

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Drugs Genome Project Genome Genomics 57

XTalks

APRIL 5, 2021

Bioinformaticians use a combination of mathematics, computer science and biology to help scientists make sense of the data gathered from research projects. The Human Genome Project could not have succeeded without the use of bioinformatics. Bioinformatics Scientist. How to Become a Bioinformatics Scientist.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59

The Pharma Data

AUGUST 24, 2020

Hong Kong scientists are reporting the case of a healthy man in his 30s who became reinfected with coronavirus four and a half months after his first bout. They say genome sequencing shows the two strains of the virus are “clearly different”, making it the world’s first proven case of reinfection. Image copyright.

Immune Response 52

Immune Response Genome Project Genome Genomics 52

XTalks

NOVEMBER 3, 2023

CRISPR works as genetic scissors to edit parts of the genome. The scientists on the advisory committee were particularly focused on the CRISPR gene editing technology itself and how companies like Vertex that are developing CRISPR-based therapies are ensuring their treatments are not making off-target gene edits.

Gene Therapy 59

Gene Therapy Gene Gene Editing In-Vivo 59

Pharmaceutical Technology

JUNE 14, 2023

All that DNA is organised into hereditary units called genes, with humans having about 25,000 genes collectively known as the genome. The Human Genome Project Launched in October 1990, The Human Genome Project sought to sequence the entire human genome using a method called Sanger sequencing.

Genome Project 130

Genome Project Medicine Genome Genomics 130

Drug Discovery World

OCTOBER 16, 2023

Our research community of clinicians, clinical trialists, discovery scientists, and statisticians develop pioneering treatments for patients and ground-breaking discoveries in basic science.” Emerging UK biotech firms like Mosaic Therapeutics, Enhanc3D Genomics, and Nucleome Therapeutics are using these genomic insights to innovate.”

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Drugs Life Science Gene Therapy Genome 75

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.

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Genome Genomics Medicine Gene 117

Drug Discovery World

JULY 19, 2023

Evan Floden , CEO of Seqera Labs examines how data sharing platforms are impacting cancer and genomics research. Increasingly, major collaborative life sciences projects, like the Human Genome Project or Human Cell Atlas, are driving advancements and organisations – both public and private – are taking note.

Genome 52

Genome Genomics Bioinformatics Genetics 52

pharmaphorum

SEPTEMBER 13, 2022

During this period, Nobel prize-winning German scientist Paul Ehrlich developed his lock-key hypothesis of molecules that specifically bind to cell receptors. Building on the success of cytokine-based immunotherapies, scientists continued to seek other areas where the immune system could be leveraged against tumours.

Genome Project 98

Genome Project Genome Genomics DNA 98

Roots Analysis

AUGUST 31, 2023

Nutrigenomics is the science studying the relationship between human genome, nutrition and health. In part, the success of the Human Genome Project has also paved a path for the novel concept of nutrigenomics. It further highlights the variation in the genome of patients and identify the sites of metabolic weakness.

Genome 40

Genome Genomics Genetics Gene 40

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.

Genetics 119

Genetics DNA Genome Genomics 119