Scienmag

JULY 4, 2025

In a groundbreaking study that promises to reshape our understanding of autism spectrum disorder (ASD), researchers have employed state-of-the-art single-cell genomic technologies to unravel the complex molecular alterations underlying dup15q syndrome—a genetic condition strongly linked to autism. Velmeshev, D.,

Gene Expression 52

Gene Expression Gene Genetics RNA 52

Scienmag

JUNE 19, 2025

Published recently in Translational Psychiatry , this multi-ancestry genome-wide association study (GWAS) integrates single nucleotide polymorphism (SNP)-by-psychosocial interaction analyses to reveal previously unidentified genetic contributors to lipid metabolism.

Genetics 59

Genetics Genomics Genome Gene 59

Scienmag

JUNE 27, 2025

The current investigation focuses on a cohort of 13 patients from Northeastern Brazil with identified HER2 mutations in NSCLC tumors, drawing attention not only to the presence of these mutations but also to their extensive genomic interplay with other oncogenic drivers. The disparity in treatment outcomes was stark.

Genetics 59

Genetics Genomics Genome Protein 59

Scienmag

JUNE 18, 2025

The approach exemplifies how coupling systematic mutagenesis with sophisticated computational modeling can unravel the complexity of the non-coding genome. This approach surpasses traditional in vitro assays by capturing the full complexity of chromatin landscape, three-dimensional genome architecture, and relevant cellular environments.

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In-Vivo Gene Expression Gene DNA 80

Scienmag

JUNE 24, 2025

In the rapidly evolving realm of psychiatric genetics, a landmark review published on June 24, 2025, in Genomic Psychiatry elucidates the intricate relationships between polygenic scores for mood disorders and clinical outcomes across major psychiatric conditions.

Genetics 52

Genetics Genomics Genome Gene 52

Scienmag

JUNE 29, 2025

Recognizing this diagnostic gap, the collaborative research initiative spearheaded by the Carlos Simón Foundation and iPremom set out to harness advanced genomics and machine learning for more sensitive, timely detection. Nature Medicine. On average, LOPE was predicted roughly 14.9 Pre-eclampsia – Fact Sheet. [3] Pérez-Moraga, R.,

Development 52

Development RNA Medicine Genomics 52

Scienmag

JULY 8, 2025

Intriguingly, these RNA molecules are derived from two principal sources: the human genome itself and the vast consortium of microbial species inhabiting the human body, collectively known as the microbiome. The scalability and sensitivity of this platform thus position it as a versatile tool in precision medicine.

RNA 81

RNA Genomics Genome Research 81

Scienmag

JUNE 13, 2025

Singapore – Scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new artificial intelligence (AI)-based method called “Fragle” that makes tracking cancer easier and faster using blood tests. ” While existing methods have their strengths, they are often complex and expensive.

DNA 59

DNA Genomics Genome Genetics 59

Scienmag

JULY 16, 2025

Traditional taxonomic profiling methods rely heavily on comparing metagenomic reads against vast genomic reference libraries. These methods, while foundational, inherently suffer from a crucial bottleneck: the genomic underrepresentation of countless microbial species that dominate natural environments yet remain uncultured and unsequenced.

Genomics 69

Genomics Genome Gene Genetics 69

Scienmag

JUNE 10, 2025

Despite significant advances through precision medicine and targeted therapies that have reshaped oncology, the issues of drug resistance and disease recurrence continue to plague many patients. Cancer remains a formidable adversary in global health, affecting millions annually and presenting persistent challenges to effective treatment.

Research 59

Research Clinical Trials Clinical Trials Gene Editing 59

Scienmag

JUNE 26, 2025

These breaks pose a serious threat to genomic stability, especially in neurons that are non-dividing and highly sensitive to DNA damage. The formation of these deleterious chromosomal alterations underscores a novel cytotoxic mechanism for cytarabine, connecting epigenetic regulation directly to genome integrity in neurons.

DNA 59

DNA Genomics Genome Regulation 59

Scienmag

JUNE 17, 2025

Crucial to this breakthrough was the integration of cutting-edge genomic technologies with translational oncology expertise. The UCSF team’s findings herald a new epoch where individualized molecular markers like CA125 and TM4SF1 can serve as linchpins for precision medicine, enabling personalized immunotherapeutic interventions.

Genomics 59

Genomics Genome Clinical Trials Clinical Trials 59

Scienmag

JULY 18, 2025

It challenges long-held paradigms rooted in single-marker analyses and points toward a future where precision medicine is informed not only by genomic data but also by spatially resolved proteomic landscapes. In conclusion, the deployment of PathoPlex presents a transformative advance in the study of immune-mediated kidney disease.

Antibody 90

Antibody In-Vivo In-Vitro Research 90

Scienmag

JUNE 19, 2025

Unlike DNA, mRNA remains transient in the cytoplasm and avoids genomic integration, mitigating concerns regarding insertional mutagenesis and other long-term genetic alterations. The advantages of utilizing mRNA are profound. This transient expression can also be advantageous where temporary modulation of immune response is desired.

In-Vivo 52

In-Vivo Engineer Manufacturing DNA 52

Scienmag

JUNE 17, 2025

At the forefront of this paradigm shift is Professor Diego di Bernardo, Genomic Medicine Program Coordinator at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and Professor of Biomedical Engineering at the University of Naples “Federico II.”

Genetics 59

Genetics Gene Therapy Gene Expression Gene 59

Scienmag

JUNE 18, 2025

The mutation rs80359550 in BRCA2 identified in this cohort was associated with more than a tenfold increase in prostate cancer risk, underscoring the gene’s pivotal involvement in DNA repair pathways that, when dysfunctional, lead to genomic instability and tumorigenesis. In conclusion, the study led by Umarane et al.

Genetics 85

Genetics DNA Genotype Genomics 85

Scienmag

JUNE 20, 2025

The integration of computational biology, immunology, and clinical medicine exemplifies a convergence that is reshaping how complex diseases are approached, moving away from descriptive paradigms toward mechanistic, individualized medicine. Importantly, the translational impact of these findings is far-reaching.

Research 81

Research Immune Response Big Data Development 81

Scienmag

JUNE 24, 2025

Published in Translational Psychiatry , this reverse translational proof-of-concept investigation bridges experimental models and clinical practice, pushing the frontier of personalized medicine in addiction treatment. Central to this advance is the multifaceted analysis of neurobiological signatures associated with AUD.

Gene Expression 52

Gene Expression Research Bioinformatics Genetics 52

Scienmag

JUNE 22, 2025

This research contributes significantly to the ongoing discourse on neonatal neuroprotection, where nutrition intersects with neurobiology and critical care medicine. Moreover, this study sets the stage for expanded multidisciplinary collaboration.

Research 59

Research Development Production Medicine 59

Scienmag

JULY 2, 2025

The nuclear medicine community has long speculated on the merit of combining metabolic indicators with anatomical changes, and this study offers compelling empirical support for this paradigm. Factors such as cost, accessibility, and expertise in interpreting dynamic PET/CT metrics must be addressed to realize widespread adoption.

Research 72

Research Genomics Genome Medicine 72

Scienmag

JULY 15, 2025

Furthermore, this research invigorates the field of precision medicine with an intergenerational dimension, where maternal health optimization holds promise not only for immediate pregnancy outcomes but for lifelong metabolic resilience in progeny.

Insulin 59

Insulin Gene Expression Research DNA 59

Scienmag

JUNE 30, 2025

Delving deeper, the researchers employed cell-type-specific genomic profiling, a technical tour de force allowing unparalleled insights into gene expression within excitatory neurons of the neocortex.

Gene Expression 80

Gene Expression Gene Regulation In-Vivo 80

Scienmag

JULY 5, 2025

This approach leverages the power of genome-wide association studies (GWAS) data and addresses the multifaceted genetic architecture of mental health disorders, moving beyond candidate gene studies that often yield inconsistent results. Importantly, the authors discuss the translational implications of their findings.

Genetics 59

Genetics Gene Gene Expression Regulation 59

Scienmag

JUNE 17, 2025

Tedersoo’s research confronts this challenge head-on by leveraging molecular and genomic tools to overcome these traditional barriers. A cornerstone of this venture involves establishing guiding principles and standards for a DNA-based phylogenetic taxonomy, which would coalesce vast genomic datasets into a coherent classification framework.

DNA 72

DNA Genomics Genome Research 72

Scienmag

JUNE 30, 2025

The potential to translate these findings into treatments ranges from immediate responses to Long COVID-associated cognitive impairment to long-term prevention of neurodegenerative disease progression, representing an urgent frontier in brain medicine.

Research 66

Research Protein Genomics Genome 66

Scienmag

JUNE 17, 2025

Winter challenges longstanding assumptions about the ineffectiveness of immunotherapy in treating pancreatic adenocarcinoma, one of the deadliest and most treatment-resistant cancers known to medicine. Pancreatic cancer is characterized by notoriously low survival rates and a limited arsenal of effective therapeutic options.

Research 59

Research Immune Response Trials Genomics 59

Scienmag

JUNE 6, 2025

This research, representing the largest genome-wide examination of its kind, reveals that the differential response to orthokeratology is linked to specific genetic variants associated with retinal function. These findings underscore the sensory retina’s active role in governing eye growth modulation and, by extension, treatment efficacy.

Gene 59

Gene Genetics Genomics Genome 59

Scienmag

JUNE 17, 2025

City of Hope researchers, led by Dr. Ravi Salgia and collaborators including Dr. Aritro Nath and Dr. Jyoti Malhotra, aim to transcend these limitations by integrating multi-parametric data—genomic, transcriptomic, proteomic, and imaging—to craft a comprehensive, temporally resolved biomap that reflects the tumor’s adaptive states.

Clinical Trials 59

Clinical Trials Clinical Trials Research Bioinformatics 59

Scienmag

JUNE 7, 2025

This revelation marks a significant advancement in neonatal medicine, suggesting that the simple and widely accessible blood group typing could be an invaluable prognostic tool in neonatal intensive care units (NICUs) worldwide.

Genetics 59

Genetics Immune Response Medicine Research 59

Scienmag

JUNE 30, 2025

To decipher this complex microbial warfare, an international team of researchers employed a multifaceted approach combining detailed genomic analysis with high-throughput agar competition assays. Furthermore, insights into the spatial and temporal dynamics of strain coexistence on skin can inform personalized medicine approaches.

Bacteria 59

Bacteria Genomics Genome In-Vivo 59

The Pharma Data

JUNE 15, 2025

Incyte’s ability to pursue a precision medicine approach is made possible by the growing understanding of the genomic abnormalities that drive disease progression in MPNs — knowledge that a sophisticated diagnostic can help identify.

Genomics 40

Genomics Genome Gene Development 40

Scienmag

JUNE 25, 2025

This tiny but indispensable structure, coined the “hemifusome,” was identified through cutting-edge cryo-electron tomography techniques by a collaborative team of researchers at the University of Virginia School of Medicine and the National Institutes of Health. Is the hemifusome involved in signaling cascades beyond cargo transport?

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Scientist Genetics Genetic Disease Medicine 75

XTalks

APRIL 22, 2025

Last month, it teamed with Curio Genomics to create a costeffective, endtoend NGS workflow that lowers barriers for largescale agrigenomics projects. This AI platform automates pharmacybenefit claims analysis and quickly flags specialtydrug savings opportunities for brokers and selffunded employers.

Life Science 59

Life Science Pharmacy Sales Nurses 59

The Pharma Data

JUNE 15, 2025

Intellia’s ongoing study stands at the intersection of biotechnology and genomic medicine, employing its proprietary CRISPR/Cas9 platform to enable permanent, targeted genome-editing. President and Chief Executive Officer of Intellia Therapeutics.

Genomics 40

Genomics Genome Allergies Medicine 40

Scienmag

JUNE 24, 2025

Drawing from large-scale genome-wide association studies conducted by the Psychiatric Genomics Consortium, the authors examined the overlaps in genetic risk profiles among the disorders. As these insights ripple through research and clinical communities, they herald a new era of precision medicine in pediatric eating disorders.

Genetics 59

Genetics Research Genomics Genome 59

Scienmag

JUNE 9, 2025

Thus, the study highlights an urgent imperative to expand genomic medicine infrastructure within oncology services, promoting seamless integration from tumor testing to genetic diagnosis.

Genetics 59

Genetics DNA Gene Genomics 59

Scienmag

JUNE 16, 2025

Proteogenomics, the interdisciplinary field combining genomics and proteomics, provides a comprehensive molecular portrait by linking genetic information to the proteome — the vast array of proteins expressed in cells. link] Keywords : Cancer genomics, Genetics, Protein functions, Phenotypic variation Boutros, P., Kislinger, T.,

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Genetics Protein Genomics Genome 52